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NameHistone H2A.Z
Synonyms
  • H2A/z
  • H2AZ
Gene NameH2AFZ
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019689|Histone H2A.Z
MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILE
YLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIG
KKGQQKTV
Number of residues128
Molecular Weight13552.635
Theoretical pINot Available
GO Classification
Functions
  • chromatin DNA binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • RNA polymerase II distal enhancer sequence-specific DNA binding
  • RNA polymerase II core promoter sequence-specific DNA binding
  • nucleosomal DNA binding
Processes
  • chromatin silencing
  • positive regulation of transcription from RNA polymerase II promoter
  • cellular response to estradiol stimulus
  • chromatin organization
Components
  • nucleus
  • extracellular exosome
  • nuclear euchromatin
  • nucleosome
  • nuclear heterochromatin
General FunctionRna polymerase ii distal enhancer sequence-specific dna binding
Specific FunctionVariant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP0C0S5
UniProtKB Entry NameH2AZ_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0019690|Histone H2A.Z (H2AFZ)
ATGGCTGGCGGTAAGGCTGGAAAGGACTCCGGAAAGGCCAAGACAAAGGCGGTTTCCCGC
TCGCAGAGAGCCGGCTTGCAGTTCCCAGTGGGCCGTATTCATCGACACCTAAAATCTAGG
ACGACCAGTCATGGACGTGTGGGCGCGACTGCCGCTGTGTACAGCGCAGCCATCCTGGAG
TACCTCACCGCAGAGGTACTTGAACTGGCAGGAAATGCATCAAAAGACTTAAAGGTAAAG
CGTATTACCCCTCGTCACTTGCAACTTGCTATTCGTGGAGATGAAGAATTGGATTCTCTC
ATCAAGGCTACAATTGCTGGTGGTGGTGTCATTCCACACATCCACAAATCTCTGATTGGG
AAGAAAGGACAACAGAAGACTGTCTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4741
Chromosome Location4
LocusNot Available
References
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