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NameHistone H2A-Bbd type 2/3
Synonyms
  • H2A Barr body-deficient
  • H2A.Bbd
  • H2ABBD
  • H2AFB
Gene NameH2AFB2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013500|Histone H2A-Bbd type 2/3
MPRRRRRRGSSGAGGRGRTCSRTVRAELSFSVSQVERSLREGHYAQRLSRTAPVYLAAVI
EYLTAKVLELAGNEAQNSGERNITPLLLDMVVHNDRLLSTLFNTTTISQVAPGED
Number of residues115
Molecular Weight12713.25
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
Processes
  • mRNA processing
  • chromatin silencing
  • nucleosome assembly
Components
  • nucleus
  • nuclear nucleosome
  • transcriptionally active chromatin
General FunctionDna binding
Specific FunctionAtypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.
Pfam Domain FunctionNot Available
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP0C5Z0
UniProtKB Entry NameH2AB2_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013501|Histone H2A-Bbd type 2/3 (H2AFB2)
ATGCCGAGGAGGAGGAGACGCCGAGGGTCCTCCGGTGCTGGCGGCCGGGGGCGGACCTGC
TCTCGCACCGTCCGAGCGGAGCTTTCGTTTTCAGTGAGCCAGGTGGAGCGCAGTCTACGG
GAGGGCCACTACGCTCAGCGCCTGAGTCGCACGGCGCCGGTCTACCTCGCTGCGGTTATT
GAGTACCTGACGGCCAAGGTCCTGGAGCTGGCGGGCAACGAGGCCCAGAACAGCGGAGAG
CGGAACATCACTCCCCTGCTGCTGGACATGGTGGTTCACAACGACAGGCTACTGAGCACC
CTTTTCAACACGACCACCATCTCTCAAGTGGCCCCTGGCGAGGACTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:18298
Chromosome LocationX
LocusNot Available
References
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  5. Okuwaki M, Kato K, Shimahara H, Tate S, Nagata K: Assembly and disassembly of nucleosome core particles containing histone variants by human nucleosome assembly protein I. Mol Cell Biol. 2005 Dec;25(23):10639-51. 16287874
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  7. Menoni H, Gasparutto D, Hamiche A, Cadet J, Dimitrov S, Bouvet P, Angelov D: ATP-dependent chromatin remodeling is required for base excision repair in conventional but not in variant H2A.Bbd nucleosomes. Mol Cell Biol. 2007 Sep;27(17):5949-56. Epub 2007 Jun 25. 17591702
  8. Eirin-Lopez JM, Ishibashi T, Ausio J: H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way. FASEB J. 2008 Jan;22(1):316-26. Epub 2007 Aug 28. 17726088
  9. Gonzalez-Romero R, Mendez J, Ausio J, Eirin-Lopez JM: Quickly evolving histones, nucleosome stability and chromatin folding: all about histone H2A.Bbd. Gene. 2008 Apr 30;413(1-2):1-7. doi: 10.1016/j.gene.2008.02.003. Epub 2008 Feb 16. 18329190
  10. Ishibashi T, Li A, Eirin-Lopez JM, Zhao M, Missiaen K, Abbott DW, Meistrich M, Hendzel MJ, Ausio J: H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis. Nucleic Acids Res. 2010 Apr;38(6):1780-9. doi: 10.1093/nar/gkp1129. Epub 2009 Dec 11. 20008104
  11. Tolstorukov MY, Goldman JA, Gilbert C, Ogryzko V, Kingston RE, Park PJ: Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells. Mol Cell. 2012 Aug 24;47(4):596-607. doi: 10.1016/j.molcel.2012.06.011. Epub 2012 Jul 12. 22795134