T3DB: Short tail fiber protein gp12

Name	Short tail fiber protein gp12
Synonyms	Gene product 12 gp12
Gene Name	12
Organism	Enterobacteria phage T4
Amino acid sequence	>lcl\|BSEQ0019395\|Short tail fiber protein gp12 MSNNTYQHVSNESRYVKFDPTDTNFPPEITDVQAAIAAISPAGVNGVPDASSTTKGILFI PTEQEVIDGTNNTKAVTPATLATRLSYPNATETVYGLTRYSTNDEAIAGVNNESSITPAK FTVALNNAFETRVSTESSNGVIKISSLPQALAGADDTTAMTPLKTQQLAIKLIAQIAPSE TTATESDQGVVQLATVAQVRQGTLREGYAISPYTFMNSSSTEEYKGVIKLGTQSEVNSNN ASVAVTGATLNGRGSTTSMRGVVKLTTTAGSQSGGDASSALAWNADVIQQRGGQIIYGTL RIEDTFTIANGGANITGTVRMTGGYIQGNRIVTQNEIDRTIPVGAIMMWAADSLPSDAWR FCHGGTVSASDCPLYASRIGTRYGGNPSNPGLPDMRGLFVRGSGRGSHLTNPNVNGNDQF GKPRLGVGCTGGYVGEVQIQQMSYHKHAGGFGEHDDLGAFGNTRRSNFVGTRKGLDWDNR SYFTNDGYEIDPESQRNSKYTLNRPELIGNETRPWNISLNYIIKVKE
Number of residues	527
Molecular Weight	56204.88
Theoretical pI	6.19
GO Classification	Functions metal ion binding Processes viral entry into host cell virion attachment to host cell Components virion
General Function	Metal ion binding
Specific Function	Structural component of the short tail fiber. Adhesion protein that binds irreversibly to the lipopolysaccharides component (LPS) on the cell surface of Escherichia coli B strains during virus attachment. After at least three long tail fibers have bound, short tail fibers extend and bind irreversibly to the core region of the host cell LPS.
Pfam Domain Function	Collar (PF07484 ) gp12-short_mid (PF09089 ) S_tail_recep_bd (PF14928 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	P10930
UniProtKB Entry Name	FIB12_BPT4
Cellular Location	Virion
Gene sequence	>lcl\|BSEQ0019396\|Short tail fiber protein gp12 (12) ATGAGTAATAATACATATCAACACGTTTCTAATGAATCTCGTTATGTAAAATTTGATCCT ACCGATACGAATTTTCCACCGGAGATTACTGATGTTCACGCTGCTATAGCAGCCATTTCT CCTGCTGGAGTAAATGGAGTTCCTGATGCATCGTCAACAACAAAGGGAATTCTATTTATT CCCACTGAACAGGAAGTTATAGATGGAACTAATAATACCAAAGCAGTTACACCAGCAACG TTGGCAACAAGATTATCTTATCCAAATGCAACTGAAACTGTTTACGGATTAACAAGATAT TCAACCAATGATGAAGCCATTGCCGGAGTTAATAATGAATCTTCTATAACTCCAGCTAAA TTTACTGTCGCCCTTAATAATGCGTTTGAAACGCGAGTTTCAACTGAATCCTCAAATGGT GTTATTAAAATTTCATCTCTACCGCAAGCATTAGCTGGTGCAGATGATACTACTGCAATG ACTCCATTAAAAACACAGCAGTTAGCTATTAAATTAATTGCGCAAATTGCTCCTTCTGAA ACCACAGCTACCGAATCGGACCAAGGTGTTGTTCAATTAGCAACAGTAGCGCAGGTTCGT CAGGGAACTTTAAGAGAAGGCTATGCAATTTCTCCTTATACGTTTATGAATTCATCTTCT ACTGAAGAATATAAAGGCGTAATTAAATTAGGAACACAATCAGAAGTTAACTCGAATAAT GCTTCTGTTGCGGTTACTGGCGCAACTCTTAATGGTCGTGGTTCTACGACGTCAATGAGA GGCGTAGTTAAATTAACTACAACCGCCGGTTCACAGAGTGGAGGCGATGCTTCATCAGCC TTAGCTTGGAATGCTGACGTTATCCAGCAAAGAGGTGGTCAAATTATCTATGGAACACTC CGCATTGAAGACACATTTACAATAGCTAATGGTGGAGCAAATATTACGGGTACCGTCAGA ATGACTGGCGGTTATATTCAAGGTAACCGCATCGTAACACAAAATGAAATTGATAGAACT ATTCCTGTCGGAGCTATTATGATGTGGGCCGCTGATAGTCTTCCTAGTGATGCTTGGCGC TTCTGCCATGGTGGAACTGTTTCAGCGTCAGATTGTCCATTATATGCTTCTAGAATTGGA ACAAGATATGGCGGAAACCCATCAAATCCTGGATTGCCTGACATGCGTGGTCTTTTTGTT CGTGGTTCTGGTCGTGGTTCTCACTTAACAAATCCAAATGTTAATGGTAATGACCAATTT GGTAAACCTAGATTAGGTGTAGGTTGTACCGGTGGATATGTTGGTGAAGTACAGATACAA CAGATGTCTTATCATAAACATGCTGGTGGATTTGGTGAGCATGATGATCTGGGGGCATTC GGTAATACCCGTAGATCAAATTTTGTTGGTACACGTAAAGGACTTGACTGGGATAACCGT TCATACTTCACCAATGACGGATATGAAATTGACCCAGAATCACAACGAAATTCCAAATAT ACATTAAATCGTCCTGAATTAATTGGAAATGAAACACGTCCATGGAACATTTCTTTAAAC TACATAATTAAGGTAAAAGAATGA
GenBank Gene ID	X06792
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	Not Available
Chromosome Location	Not Available
Locus	Not Available
References	Selivanov NA, Prilipov AG, Mesyanzhinov VV: Nucleotide and deduced amino acid sequence of bacteriophage T4 gene 12. Nucleic Acids Res. 1988 Mar 25;16(5):2334. 3357780 Miller ES, Kutter E, Mosig G, Arisaka F, Kunisawa T, Ruger W: Bacteriophage T4 genome. Microbiol Mol Biol Rev. 2003 Mar;67(1):86-156, table of contents. 12626685 Barrett BK, Berget PB: Using transposon Tn5 insertions to sequence bacteriophage T4 gene 11. DNA. 1989 May;8(4):287-95. 2548819 Prilipov AG, Selivanov NA, Efimov VP, Marusich EI, Mesyanzhinov VV: Nucleotide sequences of bacteriophage T4 genes 9, 10 and 11. Nucleic Acids Res. 1989 Apr 25;17(8):3303. 2726468 Weigele PR, Scanlon E, King J: Homotrimeric, beta-stranded viral adhesins and tail proteins. J Bacteriol. 2003 Jul;185(14):4022-30. 12837775 van Raaij MJ, Schoehn G, Burda MR, Miller S: Crystal structure of a heat and protease-stable part of the bacteriophage T4 short tail fibre. J Mol Biol. 2001 Dec 14;314(5):1137-46. 11743729