T3DB: Intron-associated endonuclease 1

Name	Intron-associated endonuclease 1
Synonyms	3.1.-.- I-TevI IRF protein
Gene Name	ITEVIR
Organism	Enterobacteria phage T4
Amino acid sequence	>lcl\|BSEQ0012075\|Intron-associated endonuclease 1 MKSGIYQIKNTLNNKVYVGSAKDFEKRWKRHFKDLEKGCHSSIKLQRSFNKHGNVFECSI LEEIPYEKDLIIERENFWIKELNSKINGYNIADATFGDTCSTHPLKEEIIKKRSETVKAK MLKLGPDGRKALYSKPGSKNGRWNPETHKFCKCGVRIQTSAYTCSKCRNRSGENNSFFNH KHSDITKSKISEKMKGKKPSNIKKISCDGVIFDCAADAARHFKISSGLVTYRVKSDKWNW FYINA
Number of residues	245
Molecular Weight	28232.2
Theoretical pI	10.26
GO Classification	Functions DNA binding endonuclease activity Processes intron homing
General Function	Endonuclease activity
Specific Function	This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing.
Pfam Domain Function	GIY-YIG (PF01541 ) NUMOD3 (PF07460 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	P13299
UniProtKB Entry Name	TEV1_BPT4
Cellular Location	Cytoplasmic
Gene sequence	>lcl\|BSEQ0012076\|Intron-associated endonuclease 1 (ITEVIR) ATGAAAAGCGGAATTTATCAGATTAAAAATACTTTAAACAATAAAGTATATGTAGGAAGT GCTAAAGATTTTGAAAAGAGATGGAAGAGGCATTTTAAAGATTTAGAAAAAGGATGCCAT TCTTCTATAAAACTTCAGAGGTCTTTTAACAAACATGGTAATGTGTTTGAATGTTCTATT TTGGAAGAAATTCCATATGAGAAAGATTTGATTATTGAACGAGAAAATTTTTGGATTAAA GAGCTTAATTCTAAAATTAATGGATACAATATTGCTGATGCAACGTTTGGTGATACATGT TCTACGCATCCATTAAAAGAAGAAATTATTAAGAAACGTTCTGAAACTGTTAAAGCTAAG ATGCTTAAACTTGGACCTGATGGTCGGAAAGCTCTTTACAGTAAACCCGGAAGTAAAAAC GGGCGTTGGAATCCAGAAACCCATAAGTTTTGTAAGTGCGGTGTTCGCATACAAACTTCT GCTTATACTTGTAGTAAATGCAGAAATCGTTCAGGTGAAAATAATTCATTCTTTAATCAT AAGCATTCAGACATAACTAAATCTAAAATATCAGAAAAGATGAAAGGTAAAAAGCCTAGT AATATTAAAAAGATTTCATGTGATGGGGTTATTTTTGATTGTGCAGCAGATGCAGCTAGA CATTTTAAAATTTCGTCTGGATTAGTTACTTATCGTGTAAAATCTGATAAATGGAATTGG TTCTACATAAATGCCTAA
GenBank Gene ID	M12742
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	Not Available
Chromosome Location	Not Available
Locus	Not Available
References	Chu FK, Maley GF, West DK, Belfort M, Maley F: Characterization of the intron in the phage T4 thymidylate synthase gene and evidence for its self-excision from the primary transcript. Cell. 1986 Apr 25;45(2):157-66. 3698096 Miller ES, Kutter E, Mosig G, Arisaka F, Kunisawa T, Ruger W: Bacteriophage T4 genome. Microbiol Mol Biol Rev. 2003 Mar;67(1):86-156, table of contents. 12626685 West DK, Changchien LM, Maley GF, Maley F: Evidence that the intron open reading frame of the phage T4 td gene encodes a specific endonuclease. J Biol Chem. 1989 Jun 25;264(18):10343-6. 2543665