NameC-C motif chemokine 2
Synonyms
  • HC11
  • MCAF
  • MCP-1
  • MCP1
  • Monocyte chemoattractant protein 1
  • Monocyte chemotactic and activating factor
  • Monocyte chemotactic protein 1
  • Monocyte secretory protein JE
  • SCYA2
  • Small-inducible cytokine A2
Gene NameCCL2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010732|C-C motif chemokine 2
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCP
KEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
Number of residues99
Molecular Weight11024.87
Theoretical pI9.72
GO Classification
Functions
  • CCR2 chemokine receptor binding
  • protein kinase activity
  • receptor binding
  • chemokine activity
  • heparin binding
Processes
  • cellular response to interleukin-1
  • cell surface receptor signaling pathway
  • JAK-STAT cascade
  • inflammatory response
  • positive regulation of cellular extravasation
  • cellular calcium ion homeostasis
  • positive regulation of collagen biosynthetic process
  • monocyte chemotaxis
  • regulation of cell shape
  • positive regulation of immune complex clearance by monocytes and macrophages
  • lipopolysaccharide-mediated signaling pathway
  • astrocyte cell migration
  • response to wounding
  • response to heat
  • chemotaxis
  • positive regulation of leukocyte mediated cytotoxicity
  • cellular response to platelet-derived growth factor stimulus
  • cellular homeostasis
  • neutrophil chemotaxis
  • positive regulation of macrophage chemotaxis
  • positive regulation of calcium ion import
  • positive regulation of ERK1 and ERK2 cascade
  • cellular response to high density lipoprotein particle stimulus
  • positive regulation of tumor necrosis factor production
  • cellular response to fibroblast growth factor stimulus
  • positive regulation of nitric-oxide synthase biosynthetic process
  • positive regulation of T cell activation
  • response to mechanical stimulus
  • cellular response to interferon-gamma
  • response to activity
  • organ regeneration
  • cellular response to retinoic acid
  • regulation of vascular endothelial growth factor production
  • endoplasmic reticulum unfolded protein response
  • signal transduction
  • cellular response to interleukin-6
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • response to progesterone
  • cellular response to tumor necrosis factor
  • response to vitamin B3
  • PERK-mediated unfolded protein response
  • eosinophil chemotaxis
  • positive regulation of protein targeting to membrane
  • cellular protein metabolic process
  • MAPK cascade
  • response to amino acid
  • cell adhesion
  • helper T cell extravasation
  • cellular response to ATP
  • response to bacterium
  • cellular response to organic cyclic compound
  • protein phosphorylation
  • cellular response to drug
  • aging
  • leukocyte migration involved in inflammatory response
  • positive regulation of GTPase activity
  • response to gamma radiation
  • response to hypoxia
  • positive regulation of monocyte chemotaxis
  • cellular response to dexamethasone stimulus
  • response to antibiotic
  • lymphocyte chemotaxis
  • protein kinase B signaling
  • positive regulation of synaptic transmission
  • vascular endothelial growth factor receptor signaling pathway
  • transforming growth factor beta receptor signaling pathway
  • maternal process involved in female pregnancy
  • macrophage chemotaxis
  • angiogenesis
  • maternal process involved in parturition
  • response to ethanol
  • positive regulation of endothelial cell proliferation
  • viral genome replication
  • negative regulation of angiogenesis
  • cellular response to insulin stimulus
  • cellular response to macrophage colony-stimulating factor stimulus
  • negative regulation of neuron apoptotic process
  • negative regulation of glial cell apoptotic process
  • chemokine-mediated signaling pathway
  • organ morphogenesis
  • negative regulation of natural killer cell chemotaxis
  • cellular response to lipopolysaccharide
  • cytoskeleton organization
  • G-protein coupled receptor signaling pathway
  • humoral immune response
  • positive regulation of apoptotic cell clearance
  • cytokine-mediated signaling pathway
Components
  • rough endoplasmic reticulum
  • perinuclear region of cytoplasm
  • C-fiber
  • perikaryon
  • extracellular region
  • axon terminus
  • dendrite
  • endocytic vesicle
  • synapse
  • extracellular space
General FunctionNot Available
Specific FunctionNot Available
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID307163
UniProtKB IDP13500
UniProtKB Entry NameCCL2_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010733|C-C motif chemokine 2 (CCL2)
ATGAAAGTCTCTGCCGCCCTTCTGTGCCTGCTGCTCATAGCAGCCACCTTCATTCCCCAA
GGGCTCGCTCAGCCAGATGCAATCAATGCCCCAGTCACCTGCTGTTATAACTTCACCAAT
AGGAAGATCTCAGTGCAGAGGCTCGCGAGCTATAGAAGAATCACCAGCAGCAAGTGTCCC
AAAGAAGCTGTGATCTTCAAGACCATTGTGGCCAAGGAGATCTGTGCTGACCCCAAGCAG
AAGTGGGTTCAGGATTCCATGGACCACCTGGACAAGCAAACCCAAACTCCGAAGACTTGA
GenBank Gene IDM24545
GeneCard IDNot Available
GenAtlas IDCCL2
HGNC IDHGNC:10618
Chromosome LocationNot Available
Locus17q11.2-q12
References
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  2. Rollins BJ, Stier P, Ernst T, Wong GG: The human homolog of the JE gene encodes a monocyte secretory protein. Mol Cell Biol. 1989 Nov;9(11):4687-95. 2513477
  3. Yoshimura T, Yuhki N, Moore SK, Appella E, Lerman MI, Leonard EJ: Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett. 1989 Feb 27;244(2):487-93. 2465924
  4. Chang HC, Hsu F, Freeman GJ, Griffin JD, Reinherz EL: Cloning and expression of a gamma-interferon-inducible gene in monocytes: a new member of a cytokine gene family. Int Immunol. 1989;1(4):388-97. 2518726
  5. Shyy YJ, Li YS, Kolattukudy PE: Structure of human monocyte chemotactic protein gene and its regulation by TPA. Biochem Biophys Res Commun. 1990 Jun 15;169(2):346-51. 2357211
  6. Yoshimura T, Leonard EJ: Human monocyte chemoattractant protein-1 (MCP-1). Adv Exp Med Biol. 1991;305:47-56. 1661560
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