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NamePhospholipase A2, membrane associated
Synonyms
  • 3.1.1.4
  • GIIC sPLA2
  • Group IIA phospholipase A2
  • Non-pancreatic secretory phospholipase A2
  • NPS-PLA2
  • Phosphatidylcholine 2-acylhydrolase 2A
  • PLA2B
  • PLA2L
  • RASF-A
Gene NamePLA2G2A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016509|Phospholipase A2, membrane associated
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
Number of residues144
Molecular Weight16082.525
Theoretical pI9.51
GO Classification
Functions
  • calcium ion binding
  • phospholipase A2 activity
  • phospholipid binding
  • calcium-dependent phospholipase A2 activity
Processes
  • positive regulation of macrophage derived foam cell differentiation
  • positive regulation of ERK1 and ERK2 cascade
  • glycerophospholipid biosynthetic process
  • phospholipid metabolic process
  • lipid catabolic process
  • phosphatidic acid biosynthetic process
  • phosphatidylcholine acyl-chain remodeling
  • phosphatidylethanolamine acyl-chain remodeling
  • phosphatidylglycerol acyl-chain remodeling
  • small molecule metabolic process
  • phosphatidylinositol acyl-chain remodeling
  • phosphatidylserine acyl-chain remodeling
  • negative regulation of epithelial cell proliferation
  • somatic stem cell population maintenance
  • defense response to Gram-positive bacterium
  • low-density lipoprotein particle remodeling
  • phosphatidic acid metabolic process
  • positive regulation of inflammatory response
Components
  • mitochondrion
  • extracellular region
  • endoplasmic reticulum
  • extracellular space
  • endoplasmic reticulum membrane
  • extracellular exosome
  • perinuclear region of cytoplasm
  • secretory granule
General FunctionPhospholipid binding
Specific FunctionThought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID190889
UniProtKB IDP14555
UniProtKB Entry NamePA2GA_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0016510|Phospholipase A2, membrane associated (PLA2G2A)
ATGAAGACCCTCCTACTGTTGGCAGTGATCATGATCTTTGGCCTACTGCAGGCCCATGGG
AATTTGGTGAATTTCCACAGAATGATCAAGTTGACGACAGGAAAGGAAGCCGCACTCAGT
TATGGCTTCTACGGCTGCCACTGTGGCGTGGGTGGCAGAGGATCCCCCAAGGATGCAACG
GATCGCTGCTGTGTCACTCATGACTGTTGCTACAAACGTCTGGAGAAACGTGGATGTGGC
ACCAAATTTCTGAGCTACAAGTTTAGCAACTCGGGGAGCAGAATCACCTGTGCAAAACAG
GACTCCTGCAGAAGTCAACTGTGTGAGTGTGATAAGGCTGCTGCCACCTGTTTTGCTAGA
AACAAGACGACCTACAATAAAAAGTACCAGTACTATTCCAATAAACACTGCAGAGGGAGC
ACCCCTCGTTGCTGA
GenBank Gene IDM22430
GeneCard IDNot Available
GenAtlas IDPLA2G2A
HGNC IDHGNC:9031
Chromosome Location1
Locus1p35
References
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  2. Kramer RM, Hession C, Johansen B, Hayes G, McGray P, Chow EP, Tizard R, Pepinsky RB: Structure and properties of a human non-pancreatic phospholipase A2. J Biol Chem. 1989 Apr 5;264(10):5768-75. 2925633
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