Cytochrome b-c1 complex subunit 7

NameCytochrome b-c1 complex subunit 7
Synonyms
  • Complex III subunit 7
  • Complex III subunit VII
  • QP-C
  • Ubiquinol-cytochrome c reductase complex 14 kDa protein
  • UQBP
Gene NameUQCRB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007397|Cytochrome b-c1 complex subunit 7
MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRM
FRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRERKEREEWAKK
Number of residues111
Molecular Weight13530.34
Theoretical pI9.23
GO Classification
Processes
  • aerobic respiration
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • small molecule metabolic process
  • cellular metabolic process
  • oxidation-reduction process
  • respiratory electron transport chain
  • oxidative phosphorylation
Components
  • mitochondrial inner membrane
  • mitochondrial respiratory chain
  • mitochondrial respiratory chain complex III
General FunctionNot Available
Specific FunctionThis is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID37580
UniProtKB IDP14927
UniProtKB Entry NameQCR7_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0012692|Cytochrome b-c1 complex subunit 7 (UQCRB)
ATGCGAGATGATACAATATACGAGGATGAAGATGTAAAAGAAGCCATAAGAAGACTTCCT
GAGAACCTTTATAATGACAGGATGTTTCGCATTAAGAGGGCACTGGACCTGAACTTGAAG
CATCAGATCTTGCCTAAAGAGCAGTGGACCAAATATGAAGAGGAAAATTTCTACCTTGAA
CCGTATCTGAAAGAGGTTATTCGGGAAAGAAAAGAAAGAGAAGAATGGGCAAAGAAGTAA
GenBank Gene IDX13585
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:12582
Chromosome Location8
Locus8q22
References
  1. Suzuki H, Hosokawa Y, Toda H, Nishikimi M, Ozawa T: Cloning and sequencing of a cDNA for human mitochondrial ubiquinone-binding protein of complex III. Biochem Biophys Res Commun. 1988 Oct 31;156(2):987-94. 3056408
  2. Suzuki H, Hosokawa Y, Toda H, Nishikimi M, Ozawa T: Isolation of a single nuclear gene encoding human ubiquinone-binding protein in complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 1989 May 30;161(1):371-8. 2543413
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  5. Suzuki H, Hosokawa Y, Toda H, Nishikimi M, Ozawa T: Common protein-binding sites in the 5'-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein. J Biol Chem. 1990 May 15;265(14):8159-63. 2159470
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