Histone H1.5

NameHistone H1.5
Synonyms
  • H1F5
  • Histone H1a
  • Histone H1b
  • Histone H1s-3
Gene NameHIST1H1B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013481|Histone H1.5
MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL
SLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK
PKAKKAGAAKAKKPAGATPKKAKKAAGAKKAVKKTPKKAKKPAAAGVKKVAKSPKKAKAA
AKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK
Number of residues226
Molecular Weight22579.945
Theoretical pINot Available
GO Classification
Functions
  • chromatin DNA binding
  • poly(A) RNA binding
  • histone deacetylase binding
Processes
  • positive regulation of cell growth
  • negative regulation of transcription from RNA polymerase II promoter
  • protein stabilization
  • chromatin organization
  • positive regulation of histone H3-K9 methylation
  • nucleosome assembly
  • establishment of protein localization to chromatin
Components
  • nuclear chromatin
  • nucleosome
  • nuclear heterochromatin
  • extracellular exosome
General FunctionPoly(a) rna binding
Specific FunctionHistone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP16401
UniProtKB Entry NameH15_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013482|Histone H1.5 (HIST1H1B)
ATGTCGGAAACCGCTCCTGCCGAGACAGCCACCCCAGCGCCGGTGGAGAAATCCCCGGCT
AAGAAGAAGGCAACTAAGAAGGCTGCCGGCGCCGGCGCTGCTAAGCGCAAAGCGACGGGG
CCCCCAGTCTCAGAGCTGATCACCAAGGCTGTGGCTGCTTCTAAGGAGCGCAATGGCCTT
TCTTTGGCAGCCCTTAAGAAGGCCTTAGCGGCCGGTGGCTACGACGTGGAGAAGAATAAC
AGCCGCATTAAGCTGGGCCTCAAGAGCTTGGTGAGCAAGGGCACCCTGGTGCAGACCAAG
GGCACTGGTGCTTCTGGCTCCTTTAAACTCAACAAGAAGGCGGCCTCCGGGGAAGCCAAG
CCCAAAGCCAAGAAGGCAGGCGCCGCTAAAGCTAAGAAGCCCGCGGGGGCCACGCCTAAG
AAGGCCAAGAAGGCTGCAGGGGCGAAAAAGGCAGTGAAGAAGACTCCGAAGAAGGCGAAG
AAGCCCGCGGCGGCTGGCGTCAAAAAGGTGGCGAAGAGCCCTAAGAAGGCCAAGGCCGCT
GCCAAACCGAAAAAGGCAACCAAGAGTCCTGCCAAGCCCAAGGCAGTTAAGCCGAAGGCG
GCAAAGCCCAAAGCCGCTAAGCCCAAAGCAGCAAAACCTAAAGCTGCAAAGGCCAAGAAG
GCGGCTGCCAAAAAGAAGTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4719
Chromosome Location6
LocusNot Available
References
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