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NameHistone H1.3
Synonyms
  • H1F3
  • Histone H1c
  • Histone H1s-2
Gene NameHIST1H1D
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019681|Histone H1.3
MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSL
AALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPK
AKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKT
PQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK
Number of residues221
Molecular Weight22349.71
Theoretical pINot Available
GO Classification
Functions
  • poly(A) RNA binding
  • chromatin DNA binding
Processes
  • nucleosome assembly
  • nucleosome positioning
  • negative regulation of transcription from RNA polymerase II promoter
Components
  • nuclear euchromatin
  • nucleosome
  • nuclear chromatin
General FunctionPoly(a) rna binding
Specific FunctionHistone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP16402
UniProtKB Entry NameH13_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0019682|Histone H1.3 (HIST1H1D)
ATGTCGGAGACTGCTCCACTTGCTCCTACCATTCCTGCACCCGCAGAAAAAACACCTGTG
AAGAAAAAGGCGAAGAAGGCAGGCGCAACTGCTGGGAAACGCAAAGCATCCGGACCCCCA
GTATCTGAGCTTATCACCAAGGCAGTGGCAGCTTCTAAGGAGCGCAGCGGCGTTTCTCTG
GCCGCGCTTAAGAAAGCGCTTGCGGCTGCTGGCTACGATGTAGAAAAAAACAACAGCCGT
ATCAAGCTTGGCCTCAAGAGCTTGGTGAGCAAAGGTACTCTGGTGCAGACCAAAGGTACC
GGTGCTTCTGGCTCCTTCAAACTCAACAAGAAAGCGGCTTCCGGGGAAGGCAAACCCAAG
GCCAAAAAGGCTGGCGCAGCCAAGCCTAGGAAGCCTGCTGGGGCAGCCAAGAAGCCCAAG
AAGGTGGCTGGCGCCGCTACCCCGAAGAAAAGCATCAAAAAGACTCCTAAGAAGGTAAAG
AAGCCAGCAACCGCTGCTGGGACCAAGAAAGTGGCCAAGAGTGCGAAAAAGGTGAAAACA
CCTCAGCCAAAAAAAGCTGCCAAGAGTCCAGCTAAGGCCAAAGCCCCTAAGCCCAAGGCG
GCCAAGCCTAAGTCGGGGAAGCCGAAGGTTACAAAGGCAAAGAAGGCAGCTCCGAAGAAA
AAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4717
Chromosome Location6
LocusNot Available
References
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