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NameCCAAT/enhancer-binding protein beta
Synonyms
  • C/EBP beta
  • LAP
  • LIP
  • Liver activator protein
  • Liver-enriched inhibitory protein
  • Nuclear factor NF-IL6
  • TCF-5
  • TCF5
  • Transcription factor 5
Gene NameCEBPB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009209|CCAAT/enhancer-binding protein beta
MQRLVAWDPACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKAAPAAPPAARPGPRPPA
GELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPPAPAPAPASSGQHHDFLSD
LFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPLHPPPPPPPPPAELKAEPGFE
PADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPAD
AKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQ
HKVLELTAENERLQKKVEQLSRELSTLRNLFKQLPEPLLASSGHC
Number of residues345
Molecular Weight36105.36
Theoretical pINot Available
GO Classification
Functions
  • RNA polymerase II regulatory region sequence-specific DNA binding
  • protein heterodimerization activity
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • DNA binding
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
  • chromatin binding
  • protein homodimerization activity
  • transcription factor activity, sequence-specific DNA binding
Processes
  • negative regulation of transcription, DNA-templated
  • positive regulation of transcription from RNA polymerase II promoter
  • hepatocyte proliferation
  • brown fat cell differentiation
  • acute-phase response
  • regulation of interleukin-6 biosynthetic process
  • defense response to bacterium
  • regulation of transcription involved in cell fate commitment
  • ovarian follicle development
  • T-helper 1 cell activation
  • response to lipopolysaccharide
  • positive regulation of fat cell differentiation
  • embryonic placenta development
  • mammary gland epithelial cell proliferation
  • negative regulation of T cell proliferation
  • immune response
  • positive regulation of osteoblast differentiation
  • regulation of osteoclast differentiation
  • positive regulation of interleukin-4 production
  • inflammatory response
  • liver regeneration
  • negative regulation of neuron apoptotic process
  • transcription from RNA polymerase II promoter
  • response to endoplasmic reticulum stress
  • neuron differentiation
  • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
  • regulation of transcription, DNA-templated
  • mammary gland epithelial cell differentiation
  • cellular response to amino acid stimulus
  • granuloma formation
Components
  • cytoplasm
  • nuclear matrix
  • nucleus
  • condensed chromosome, centromeric region
  • nucleoplasm
  • nuclear chromatin
  • CHOP-C/EBP complex
General FunctionTranscriptional activator activity, rna polymerase ii core promoter proximal region sequence-specific binding
Specific FunctionImportant transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity).Isoform 2: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP17676
UniProtKB Entry NameCEBPB_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013674|CCAAT/enhancer-binding protein beta (CEBPB)
ATGGAAGTGGCCAACTTCTACTACGAGGCGGACTGCTTGGCTGCTGCGTACGGCGGCAAG
GCGGCCCCCGCGGCGCCCCCCGCGGCCAGACCCGGGCCGCGCCCCCCCGCCGGCGAGCTG
GGCAGCATCGGCGACCACGAGCGCGCCATCGACTTCAGCCCGTACCTGGAGCCGCTGGGC
GCGCCGCAGGCCCCGGCGCCCGCCACGGCCACGGACACCTTCGAGGCGGCTCCGCCCGCG
CCCGCCCCCGCGCCCGCCTCCTCCGGGCAGCACCACGACTTCCTCTCCGACCTCTTCTCC
GACGACTACGGGGGCAAGAACTGCAAGAAGCCGGCCGAGTACGGCTACGTGAGCCTGGGG
CGCCTGGGGGCCGCCAAGGGCGCGCTGCACCCCGGCTGCTTCGCGCCCCTGCACCCACCG
CCCCCGCCGCCGCCGCCGCCCGCCGAGCTCAAGGCGGAGCCGGGCTTCGAGCCCGCGGAC
TGCAAGCGGAAGGAGGAGGCCGGGGCGCCGGGCGGCGGCGCAGGCATGGCGGCGGGCTTC
CCGTACGCGCTGCGCGCTTACCTCGGCTACCAGGCGGTGCCGAGCGGCAGCAGCGGGAGC
CTCTCCACGTCCTCCTCGTCCAGCCCGCCCGGCACGCCGAGCCCCGCTGACGCCAAGGCG
CCCCCGACCGCCTGCTACGCGGGGGCCGCGCCGGCGCCCTCGCAGGTCAAGAGCAAGGCC
AAGAAGACCGTGGACAAGCACAGCGACGAGTACAAGATCCGGCGCGAGCGCAACAACATC
GCCGTGCGCAAGAGCCGCGACAAGGCCAAGATGCGCAACCTGGAGACGCAGCACAAGGTC
CTGGAGCTCACGGCCGAGAACGAGCGGCTGCAGAAGAAGGTGGAGCAGCTGTCGCGCGAG
CTCAGCACCCTGCGGAACTTGTTCAAGCAGCTGCCCGAGCCCCTGCTCGCCTCCTCCGGC
CACTGCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:1834
Chromosome Location20
LocusNot Available
References
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