Insulin-like growth factor-binding protein 3

NameInsulin-like growth factor-binding protein 3
Synonyms
  • IBP-3
  • IBP3
Gene NameIGFBP3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001931|Insulin-like growth factor-binding protein 3
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
Number of residues291
Molecular Weight31673.87
Theoretical pI8.78
GO Classification
Functions
  • insulin-like growth factor I binding
  • insulin-like growth factor II binding
  • insulin-like growth factor binding
  • metal ion binding
  • fibronectin binding
  • protein tyrosine phosphatase activator activity
Processes
  • positive regulation of catalytic activity
  • apoptotic process
  • positive regulation of insulin-like growth factor receptor signaling pathway
  • negative regulation of cell proliferation
  • positive regulation of myoblast differentiation
  • protein phosphorylation
  • type B pancreatic cell proliferation
  • negative regulation of smooth muscle cell migration
  • negative regulation of signal transduction
  • positive regulation of MAPK cascade
  • regulation of glucose metabolic process
  • negative regulation of smooth muscle cell proliferation
  • regulation of insulin-like growth factor receptor signaling pathway
  • regulation of cell growth
  • positive regulation of apoptotic process
  • osteoblast differentiation
  • negative regulation of protein phosphorylation
  • cellular protein metabolic process
Components
  • extracellular region
  • nucleus
  • extracellular space
  • insulin-like growth factor binding protein complex
  • insulin-like growth factor ternary complex
  • extracellular exosome
General FunctionProtein tyrosine phosphatase activator activity
Specific FunctionIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID183116
UniProtKB IDP17936
UniProtKB Entry NameIBP3_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0010680|Insulin-like growth factor-binding protein 3 (IGFBP3)
ATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGC
GGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGC
GAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAG
CTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCG
TGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAG
GCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTC
AGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCG
GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTG
TCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCT
AAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTC
TCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACA
CTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGT
GACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGC
TTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAG
GAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAG
GenBank Gene IDM31159
GeneCard IDNot Available
GenAtlas IDIGFBP3
HGNC IDHGNC:5472
Chromosome Location7
Locus7p13-p12
References
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