NameDeacetoxycephalosporin C synthase
Synonyms
  • 1.14.20.1
  • DAOCS
  • Expandase
Gene NamecefE
OrganismStreptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)
Amino acid sequence
>lcl|BSEQ0011313|Deacetoxycephalosporin C synthase
MDTTVPTFSLAELQQGLHQDEFRRCLRDKGLFYLTDCGLTDTELKSAKDLVIDFFEHGSE
AEKRAVTSPVPTMRRGFTGLESESTAQITNTGSYSDYSMCYSMGTADNLFPSGDFERIWT
QYFDRQYTASRAVAREVLRATGTEPDGGVEAFLDCEPLLRFRYFPQVPEHRSAEEQPLRM
APHYDLSMVTLIQQTPCANGFVSLQAEVGGAFTDLPYRPDAVLVFCGAIATLVTGGQVKA
PRHHVAAPRRDQIAGSSRTSSVFFLRPNADFTFSVPLARECGFDVSLDGETATFQDWIGG
NYVNIRRTSKA
Number of residues311
Molecular Weight34555.38
Theoretical pI4.94
GO Classification
Functions
  • deacetoxycephalosporin-C synthase activity
  • iron ion binding
  • L-ascorbic acid binding
Processes
  • antibiotic biosynthetic process
General FunctionL-ascorbic acid binding
Specific FunctionCatalyzes the step from penicillin N to deacetoxy-cephalosporin C.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID153205
UniProtKB IDP18548
UniProtKB Entry NameCEFE_STRC2
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0003631|936 bp
ATGGACACGACGGTGCCCACCTTCAGCCTGGCCGAACTCCAGCAGGGCCTGCACCAGGAC
GAGTTCCGCAGGTGTCTGAGGGACAAGGGCCTCTTCTATCTGACGGACTGCGGTCTGACC
GACACCGAGCTGAAGTCGGCCAAGGACCTCGTCATCGACTTCTTCGAGCACGGCAGCGAG
GCGGAGAAGCGCGCCGTCACCTCGCCCGTCCCCACCATGCGCCGCGGCTTCACCGGGCTG
GAGTCGGAGAGCACCGCCCAGATCACCAATACCGGCAGCTACTCCGACTACTCGATGTGC
TACTCGATGGGCACCGCGGACAACCTCTTCCCGTCCGGTGACTTCGAGCGGATCTGGACC
CAGTACTTCGACCGCCAGTACACCGCCTCCCGCGCGGTCGCCCGGGAGGTCCTGCGGGCG
ACCGGGACCGAGCCCGACGGCGGGGTCGAGGCCTTCCTCGACTGCGAGCCGCTGCTGCGG
TTCCGCTACTTCCCGCAGGTCCCCGAGCACCGCAGCGCCGAGGAGCAGCCCCTGCGGATG
GCGCCGCACTACGACCTGTCGATGGTCACCCTCATCCAGCAGACACCCTGCGCCAACGGC
TTCGTCAGCCTCCAGGCCGAGGTCGGCGGCGCGTTCACGGACCTGCCCTACCGTCCGGAC
GCCGTCCTCGTCTTCTGCGGCGCCATCGCGACCCTGGTGACCGGCGGCCAGGTCAAGGCC
CCCCGGCACCATGTCGCGGCCCCCCGCAGGGACCAGATAGCGGGCAGCAGCCGCACCTCC
AGTGTGTTCTTCCTCCGTCCCAACGCGGACTTCACCTTCTCCGTCCCGCTGGCGCGCGAG
TGCGGCTTCGATGTCAGCCTGGACGGCGAGACCGCCACGTTCCAGGATTGGATCGGGGGC
AACTACGTGAACATCCGCCGCACATCCAAGGCATAG
GenBank Gene IDM32324
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Kovacevic S, Weigel BJ, Tobin MB, Ingolia TD, Miller JR: Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase. J Bacteriol. 1989 Feb;171(2):754-60. 2644235
  2. Kovacevic S, Tobin MB, Miller JR: The beta-lactam biosynthesis genes for isopenicillin N epimerase and deacetoxycephalosporin C synthetase are expressed from a single transcript in Streptomyces clavuligerus. J Bacteriol. 1990 Jul;172(7):3952-8. 1694525