Voltage-dependent anion-selective channel protein 1

NameVoltage-dependent anion-selective channel protein 1
Synonyms
  • Outer mitochondrial membrane protein porin 1
  • Plasmalemmal porin
  • Porin 31HL
  • Porin 31HM
  • VDAC
  • VDAC-1
Gene NameVDAC1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0011766|Voltage-dependent anion-selective channel protein 1
MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLET
KYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKR
EHINLGCDMDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQL
HTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNS
SLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA
Number of residues283
Molecular Weight30772.39
Theoretical pI8.89
GO Classification
Functions
  • voltage-gated anion channel activity
  • porin activity
  • protein kinase binding
  • ion channel binding
Processes
  • epithelial cell differentiation
  • regulation of anion transmembrane transport
  • macromitophagy
  • mitochondrial calcium ion transport
  • neuron-neuron synaptic transmission
  • apoptotic process
  • regulation of mitophagy
  • learning
  • macroautophagy
  • anion transport
  • viral process
  • behavioral fear response
Components
  • mitochondrial inner membrane
  • plasma membrane
  • mitochondrial outer membrane
  • extracellular exosome
  • myelin sheath
  • membrane raft
  • pore complex
  • mitochondrion
  • membrane
  • mitochondrial nucleoid
  • nucleus
General FunctionVoltage-gated anion channel activity
Specific FunctionForms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).
Pfam Domain Function
Transmembrane Regions26-35 39-47 54-64 69-76 80-89 95-104 111-120 123-130 137-145 150-158 163-175 178-185 189-198 202-211 218-227 231-238 242-251 254-263 273-282
GenBank Protein IDNot Available
UniProtKB IDP21796
UniProtKB Entry NameVDAC1_HUMAN
Cellular LocationMitochondrion outer membrane
Gene sequence
>lcl|BSEQ0011767|Voltage-dependent anion-selective channel protein 1 (VDAC1)
ATGGCTGTGCCACCCACGTATGCCGATCTTGGCAAATCTGCCAGGGATGTCTTCACCAAG
GGCTATGGATTTGGCTTAATAAAGCTTGATTTGAAAACAAAATCTGAGAATGGATTGGAA
TTTACAAGCTCAGGCTCAGCCAACACTGAGACCACCAAAGTGACGGGCAGTCTGGAAACC
AAGTACAGATGGACTGAGTACGGCCTGACGTTTACAGAGAAATGGAATACCGACAATACA
CTAGGCACCGAGATTACTGTGGAAGATCAGCTTGCACGTGGACTGAAGCTGACCTTCGAT
TCATCCTTCTCACCTAACACTGGGAAAAAAAATGCTAAAATCAAGACAGGGTACAAGCGG
GAGCACATTAACCTGGGCTGCGACATGGATTTCGACATTGCTGGGCCTTCCATCCGGGGT
GCTCTGGTGCTAGGTTACGAGGGCTGGCTGGCCGGCTACCAGATGAATTTTGAGACTGCA
AAATCCCGAGTGACCCAGAGCAACTTTGCAGTTGGCTACAAGACTGATGAATTCCAGCTT
CACACTAATGTGAATGACGGGACAGAGTTTGGCGGCTCCATTTACCAGAAAGTGAACAAG
AAGTTGGAGACCGCTGTCAATCTTGCCTGGACAGCAGGAAACAGTAACACGCGCTTCGGA
ATAGCAGCCAAGTATCAGATTGACCCTGACGCCTGCTTCTCGGCTAAAGTGAACAACTCC
AGCCTGATAGGTTTAGGATACACTCAGACTCTAAAGCCAGGTATTAAACTGACACTGTCA
GCTCTTCTGGATGGCAAGAACGTCAATGCTGGTGGCCACAAGCTTGGTCTAGGACTGGAA
TTTCAAGCATAA
GenBank Gene IDL06132
GeneCard IDNot Available
GenAtlas IDVDAC1
HGNC IDHGNC:12669
Chromosome Location5
Locus5q31
References
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