Potassium voltage-gated channel subfamily A member 4
| Name | Potassium voltage-gated channel subfamily A member 4 |
|---|---|
| Synonyms |
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| Gene Name | KCNA4 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0013149|Potassium voltage-gated channel subfamily A member 4 MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGG SHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP ESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV GSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS TSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV |
| Number of residues | 653 |
| Molecular Weight | 73256.64 |
| Theoretical pI | Not Available |
| GO Classification | Functions
Processes
Components
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| General Function | Voltage-gated potassium channel activity |
| Specific Function | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368). |
| Pfam Domain Function | |
| Transmembrane Regions | 305-326 371-392 404-424 440-460 476-497 539-567 |
| GenBank Protein ID | Not Available |
| UniProtKB ID | P22459 |
| UniProtKB Entry Name | KCNA4_HUMAN |
| Cellular Location | Cell membrane |
| Gene sequence | >lcl|BSEQ0013150|Potassium voltage-gated channel subfamily A member 4 (KCNA4) ATGGAGGTTGCAATGGTGAGTGCGGAGAGCTCAGGGTGCAACAGTCACATGCCTTATGGT TATGCTGCCCAGGCCCGGGCCCGGGAGCGGGAGAGGCTTGCTCACTCCAGGGCAGCTGCA GCAGCTGCTGTTGCAGCGGCCACAGCTGCTGTCGAAGGTAGCGGGGGTTCTGGTGGGGGC TCCCACCACCACCACCAGTCACGCGGGGCCTGTACCTCCCATGACCCTCAGAGCAGCCGG GGTAGTCGGAGGAGGAGGCGACAGCGGTCTGAGAAGAAGAAAGCCCACTACCGGCAGAGC AGCTTCCCTCATTGCTCTGACCTGATGCCCAGTGGCTCTGAGGAGAAGATCCTGAGGGAG CTGAGTGAGGAGGAGGAAGATGAGGAGGAGGAGGAAGAGGAGGAAGAGGAGGGAAGGTTT TACTATAGTGAAGATGACCATGGTGATGAGTGTTCCTACACGGATCTGCTGCCTCAGGAT GAGGGCGGTGGCGGCTACAGTTCAGTCCGCTACAGTGACTGTTGTGAACGTGTGGTGATA AATGTGTCAGGCCTACGCTTTGAGACCCAAATGAAAACTCTGGCCCAGTTTCCAGAGACT TTGTTGGGAGACCCTGAAAAGAGGACTCAGTACTTTGACCCTTTGCGCAATGAGTATTTT TTTGACAGGAACCGCCCCAGCTTTGATGCCATCTTGTATTATTATCAATCAGGAGGCCGC CTGAAGAGGCCAGTCAATGTCCCCTTTGATATCTTCACTGAGGAGGTGAAGTTCTATCAG TTGGGGGAGGAGGCCCTGTTGAAGTTTCGGGAGGACGAGGGCTTTGTGAGAGAAGAGGAA GACAGGGCCCTCCCCGAGAATGAATTTAAAAAGCAGATTTGGCTCCTCTTTGAATATCCA GAGAGCTCCAGTCCTGCAAGGGGCATAGCCATTGTGTCCGTCCTGGTCATCTTAATCTCC ATTGTCATCTTTTGCCTGGAAACCTTGCCTGAGTTTAGGGACGACAGGGATCTCGTCATG GCACTGAGTGCTGGCGGGCATGGTGGGTTGTTGAATGATACTTCAGCACCCCATCTGGAG AACTCAGGGCACACAATATTCAATGACCCCTTCTTCATCGTGGAAACAGTCTGTATTGTA TGGTTTTCCTTTGAGTTTGTGGTTCGCTGCTTTGCTTGTCCCAGCCAAGCACTCTTCTTC AAAAACATCATGAACATCATTGACATTGTCTCCATTTTGCCTTACTTCATCACACTGGGC ACTGACCTGGCCCAGCAACAGGGGGGTGGCAATGGTCAGCAGCAGCAGGCCATGTCCTTT GCCATCCTCAGAATCATTCGTCTGGTCCGAGTATTCCGGATCTTCAAACTCTCCAGGCAC TCCAAAGGCCTGCAGATCCTGGGCCACACCCTCAGAGCCAGCATGCGGGAACTGGGCCTT CTGATCTTCTTCCTCTTCATTGGGGTCATCCTCTTTTCTAGTGCTGTGTATTTTGCAGAG GCGGATGAACCTACTACCCATTTCCAAAGCATCCCAGATGCATTTTGGTGGGCTGTGGTG ACCATGACAACTGTGGGCTATGGGGACATGAAGCCCATCACTGTAGGGGGCAAGATTGTC GGGTCCCTGTGTGCCATTGCGGGTGTCTTAACCATTGCTTTGCCAGTGCCAGTGATTGTC TCTAACTTTAACTATTTCTACCACAGAGAGACTGAAAATGAGGAACAGACACAGCTAACG CAGAATGCAGTCAGTTGTCCATACCTCCCCTCTAATTTGCTCAAGAAATTTCGGAGCTCT ACTTCTTCTTCCCTGGGGGACAAGTCAGAGTATCTAGAGATGGAAGAAGGAGTTAAGGAA TCTCTGTGTGCAAAGGAGGAGAAGTGTCAGGGAAAGGGGGATGACAGTGAGACAGATAAA AACAACTGTTCTAATGCAAAGGCTGTGGAGACTGATGTGTGA |
| GenBank Gene ID | Not Available |
| GeneCard ID | Not Available |
| GenAtlas ID | Not Available |
| HGNC ID | HGNC:6222 |
| Chromosome Location | 11 |
| Locus | Not Available |
| References |
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