Proteasome subunit alpha type-3

NameProteasome subunit alpha type-3
Synonyms
  • 3.4.25.1
  • HC8
  • Macropain subunit C8
  • Multicatalytic endopeptidase complex subunit C8
  • Proteasome component C8
  • PSC8
Gene NamePSMA3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007489|Proteasome subunit alpha type-3
MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYE
EGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYV
HAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKL
QMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA
KESLKEEDESDDDNM
Number of residues255
Molecular Weight28432.97
Theoretical pI4.97
GO Classification
Functions
  • threonine-type endopeptidase activity
  • endopeptidase activity
Processes
  • fibroblast growth factor receptor signaling pathway
  • programmed cell death
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • insulin receptor signaling pathway
  • small GTPase mediated signal transduction
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • MAPK cascade
  • cellular nitrogen compound metabolic process
  • antigen processing and presentation of peptide antigen via MHC class I
  • negative regulation of apoptotic process
  • gene expression
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • negative regulation of canonical Wnt signaling pathway
  • neurotrophin TRK receptor signaling pathway
  • regulation of apoptotic process
  • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • Ras protein signal transduction
  • small molecule metabolic process
  • NIK/NF-kappaB signaling
  • stimulatory C-type lectin receptor signaling pathway
  • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  • vascular endothelial growth factor receptor signaling pathway
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • antigen processing and presentation of exogenous peptide antigen via MHC class I
  • axon guidance
  • protein polyubiquitination
  • polyamine metabolic process
  • epidermal growth factor receptor signaling pathway
  • regulation of mRNA stability
  • mitotic cell cycle
  • innate immune response
  • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • Fc-epsilon receptor signaling pathway
  • tumor necrosis factor-mediated signaling pathway
  • T cell receptor signaling pathway
  • positive regulation of canonical Wnt signaling pathway
  • regulation of cellular amino acid metabolic process
  • activation of MAPKK activity
  • viral process
  • apoptotic process
  • proteasomal ubiquitin-independent protein catabolic process
Components
  • proteasome core complex, alpha-subunit complex
  • cytosol
  • extracellular exosome
  • nucleoplasm
  • proteasome core complex
  • cytoplasm
  • nucleus
  • proteasome complex
General FunctionThreonine-type endopeptidase activity
Specific FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID220028
UniProtKB IDP25788
UniProtKB Entry NamePSA3_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0012729|Proteasome subunit alpha type-3 (PSMA3)
ATGAGCTCAATCGGCACTGGGTATGACCTGTCAGCCTCTACATTCTCTCCTGACGGAAGA
GTTTTTCAAGTTGAATATGCTATGAAGGCTGTGGAAAATAGTAGTACAGCTATTGGAATC
AGATGCAAAGATGGTGTTGTCTTTGGGGTAGAAAAATTAGTCCTTTCTAAACTTTATGAA
GAAGGTTCCAACAAAAGACTTTTTAATGTTGATCGGCATGTTGGAATGGCAGTAGCAGGT
TTGTTGGCAGATGCTCGTTCTTTAGCAGACATAGCAAGAGAAGAAGCTTCCAACTTCAGA
TCTAACTTTGGCTACAACATTCCACTAAAACATCTTGCAGACAGAGTGGCCATGTATGTG
CATGCATATACACTCTACAGTGCTGTTAGACCTTTTGGCTGCAGTTTCATGTTAGGGTCT
TACAGTGTGAATGACGGTGCGCAACTCTACATGATTGACCCATCAGGTGTTTCATACGGT
TATTGGGGCTGTGCCATCGGCAAAGCCAGGCAAGCTGCAAAGACGGAAATAGAGAAGCTT
CAGATGAAAGAAATGACCTGCCGTGATATCGTTAAAGAAGTTGCAAAAATAATTTACATA
GTACATGACGAAGTTAAGGATAAAGCTTTTGAACTAGAACTCAGCTGGGTTGGTGAATTA
ACTAATGGAAGACATGAAATTGTTCCAAAAGATATAAGAGAAGAAGCAGAGAAATATGCT
AAGGAATCTCTGAAGGAAGAAGATGAATCAGATGATGATAATATGTAA
GenBank Gene IDD00762
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9532
Chromosome Location14
Locus14q23
References
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