Tmic
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NameMitogen-activated protein kinase 3
Synonyms
  • 2.7.11.24
  • ERK-1
  • ERK1
  • ERT2
  • Extracellular signal-regulated kinase 1
  • Insulin-stimulated MAP2 kinase
  • MAP kinase 3
  • MAP kinase isoform p44
  • Microtubule-associated protein 2 kinase
  • p44-ERK1
  • p44-MAPK
  • PRKM3
Gene NameMAPK3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002115|Mitogen-activated protein kinase 3
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
Number of residues379
Molecular Weight43135.16
Theoretical pI6.74
GO Classification
Functions
  • MAP kinase activity
  • phosphatase binding
  • ATP binding
Processes
  • caveolin-mediated endocytosis
  • transcription initiation from RNA polymerase I promoter
  • positive regulation of protein phosphorylation
  • regulation of early endosome to late endosome transport
  • protein phosphorylation
  • gene expression
  • activation of MAPK activity
  • toll-like receptor 9 signaling pathway
  • cellular response to heat
  • positive regulation of cyclase activity
  • Fc-epsilon receptor signaling pathway
  • regulation of Golgi inheritance
  • Ras protein signal transduction
  • arachidonic acid metabolic process
  • toll-like receptor signaling pathway
  • lung morphogenesis
  • negative regulation of apolipoprotein binding
  • cellular response to mechanical stimulus
  • vascular endothelial growth factor receptor signaling pathway
  • regulation of sequence-specific DNA binding transcription factor activity
  • blood coagulation
  • BMP signaling pathway
  • toll-like receptor TLR1
  • MAPK import into nucleus
  • sensory perception of pain
  • response to epidermal growth factor
  • peptidyl-serine phosphorylation
  • toll-like receptor TLR6
  • MyD88-dependent toll-like receptor signaling pathway
  • activation of MAPKK activity
  • response to exogenous dsRNA
  • axon guidance
  • JAK-STAT cascade involved in growth hormone signaling pathway
  • trachea formation
  • MyD88-independent toll-like receptor signaling pathway
  • apoptotic process
  • response to toxic substance
  • stress-activated MAPK cascade
  • small GTPase mediated signal transduction
  • DNA damage induced protein phosphorylation
  • TRIF-dependent toll-like receptor signaling pathway
  • positive regulation of telomerase activity
  • fibroblast growth factor receptor signaling pathway
  • cell cycle
  • cytokine-mediated signaling pathway
  • toll-like receptor 10 signaling pathway
  • positive regulation of histone acetylation
  • epidermal growth factor receptor signaling pathway
  • positive regulation of translation
  • positive regulation of telomere capping
  • insulin receptor signaling pathway
  • phosphorylation
  • toll-like receptor 2 signaling pathway
  • positive regulation of histone phosphorylation
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • viral process
  • regulation of stress-activated MAPK cascade
  • positive regulation of telomere maintenance via telomerase
  • MAPK cascade
  • platelet activation
  • lipopolysaccharide-mediated signaling pathway
  • toll-like receptor 3 signaling pathway
  • interleukin-1-mediated signaling pathway
  • innate immune response
  • cartilage development
  • ERK1 and ERK2 cascade
  • regulation of cellular response to heat
  • neurotrophin TRK receptor signaling pathway
  • protein complex assembly
  • toll-like receptor 4 signaling pathway
  • transcription from RNA polymerase I promoter
  • peptidyl-tyrosine autophosphorylation
  • regulation of cytoskeleton organization
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of ERK1 and ERK2 cascade
  • toll-like receptor 5 signaling pathway
Components
  • cytoskeleton
  • microtubule cytoskeleton
  • cytosol
  • extracellular exosome
  • pseudopodium
  • nucleus
  • nucleoplasm
  • caveola
  • late endosome
  • early endosome
  • nuclear envelope
  • mitochondrion
  • protein complex
  • focal adhesion
  • Golgi apparatus
General FunctionPhosphatase binding
Specific FunctionSerine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31221
UniProtKB IDP27361
UniProtKB Entry NameMK03_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021655|Mitogen-activated protein kinase 3 (MAPK3)
ATGGCGGCGGCGGCGGCTCAGGGGGGCGGGGGCGGGGAGCCCCGTAGAACCGAGGGGGTC
GGCCCGGGGGTCCCGGGGGAGGTGGAGATGGTGAAGGGGCAGCCGTTCGACGTGGGCCCG
CGCTACACGCAGTTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCGGCCTAT
GACCACGTGCGCAAGACTCGCGTGGCCATCAAGAAGATCAGCCCCTTCGAACATCAGACC
TACTGCCAGCGCACGCTCCGGGAGATCCAGATCCTGCTGCGCTTCCGCCATGAGAATGTC
ATCGGCATCCGAGACATTCTGCGGGCGTCCACCCTGGAAGCCATGAGAGATGTCTACATT
GTGCAGGACCTGATGGAGACTGACCTGTACAAGTTGCTGAAAAGCCAGCAGCTGAGCAAT
GACCATATCTGCTACTTCCTCTACCAGATCCTGCGGGGCCTCAAGTACATCCACTCCGCC
AACGTGCTCCACCGAGATCTAAAGCCCTCCAACCTGCTCATCAACACCACCTGCGACCTT
AAGATTTGTGATTTCGGCCTGGCCCGGATTGCCGATCCTGAGCATGACCACACCGGCTTC
CTGACGGAGTATGTGGCTACGCGCTGGTACCGGGCCCCAGAGATCATGCTGAACTCCAAG
GGCTATACCAAGTCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCT
AACCGGCCCATCTTCCCTGGCAAGCACTACCTGGATCAGCTCAACCACATTCTGGGCATC
CTGGGCTCCCCATCCCAGGAGGACCTGAATTGTATCATCAACATGAAGGCCCGAAACTAC
CTACAGTCTCTGCCCTCCAAGACCAAGGTGGCTTGGGCCAAGCTTTTCCCCAAGTCAGAC
TCCAAAGCCCTTGACCTGCTGGACCGGATGTTAACCTTTAACCCCAATAAACGGATCACA
GTGGAGGAAGCGCTGGCTCACCCCTACCTGGAGCAGTACTATGACCCGACGGATGAGGTG
GGCCAGTCCCCAGCAGCAGTGGGGCTGGGGGCAGGGGAGCAGGGGGGCACGTAG
GenBank Gene IDX60188
GeneCard IDNot Available
GenAtlas IDMAPK3
HGNC IDHGNC:6877
Chromosome Location16
Locus16p11.2
References
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