Proteasome subunit beta type-5

NameProteasome subunit beta type-5
Synonyms
  • 3.4.25.1
  • LMPX
  • Macropain epsilon chain
  • MB1
  • Multicatalytic endopeptidase complex epsilon chain
  • Proteasome chain 6
  • Proteasome epsilon chain
  • Proteasome subunit MB1
  • Proteasome subunit X
  • X
Gene NamePSMB5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037858|Proteasome subunit beta type-5
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
Number of residues263
Molecular Weight28480.01
Theoretical pI8.68
GO Classification
Functions
  • endopeptidase activity
  • threonine-type endopeptidase activity
Processes
  • positive regulation of canonical Wnt signaling pathway
  • regulation of cellular amino acid metabolic process
  • activation of MAPKK activity
  • viral process
  • apoptotic process
  • programmed cell death
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • fibroblast growth factor receptor signaling pathway
  • proteasomal ubiquitin-independent protein catabolic process
  • response to oxidative stress
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • insulin receptor signaling pathway
  • small GTPase mediated signal transduction
  • antigen processing and presentation of peptide antigen via MHC class I
  • MAPK cascade
  • cellular nitrogen compound metabolic process
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • negative regulation of apoptotic process
  • gene expression
  • regulation of apoptotic process
  • negative regulation of canonical Wnt signaling pathway
  • neurotrophin TRK receptor signaling pathway
  • small molecule metabolic process
  • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • Ras protein signal transduction
  • NIK/NF-kappaB signaling
  • stimulatory C-type lectin receptor signaling pathway
  • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  • vascular endothelial growth factor receptor signaling pathway
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • antigen processing and presentation of exogenous peptide antigen via MHC class I
  • axon guidance
  • protein polyubiquitination
  • polyamine metabolic process
  • epidermal growth factor receptor signaling pathway
  • regulation of mRNA stability
  • mitotic cell cycle
  • innate immune response
  • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • Fc-epsilon receptor signaling pathway
  • tumor necrosis factor-mediated signaling pathway
  • T cell receptor signaling pathway
Components
  • centrosome
  • proteasome core complex
  • nucleus
  • proteasome complex
  • cytosol
  • extracellular exosome
  • nucleoplasm
  • cytoplasm
General FunctionThreonine-type endopeptidase activity
Specific FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID558526
UniProtKB IDP28074
UniProtKB Entry NamePSB5_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019273|Proteasome subunit beta type-5 (PSMB5)
ATGGCTGGGGGCGCAGCGGATTGCAGCTTCTGGGAACGGCTGTTGGCTCGGCAATGTCGA
ATCTATGAGCTTCGAAATAAGGAACGCATCTCTGTAGCAGCTGCCTCCAAACTGCTTGCC
AACATGGTGTATCAGTACAAAGGCATGGGGCTGTCCATGGGCACCATGATCTGTGGCTGG
GATAAGAGAGGCCCTGGCCTCTACTACGTGGACAGTGAAGGGAACCGGATTTCAGGGGCC
ACCTTCTCTGTAGGTTCTGGCTCTGTGTATGCATATGGGGTCATGGATCGGGGCTATTCC
TATGACCTGGAAGTGGAGCAGGCCTATGATCTGGCCCGTCGAGCCATCTACCAAGCCACC
TACAGAGATGCCTACTCAGGAGGTGCAGTCAACCTCTACCACGTGCGGGAGGATGGCTGG
ATCCGAGTCTCCAGTGACAATGTGGCTGATCTACATGAGAAGTATAGTGGCTCTACCCCC
TGA
GenBank Gene IDD29011
GeneCard IDNot Available
GenAtlas IDPSMB5
HGNC IDHGNC:9542
Chromosome Location14
Locus14q11.2
References
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