NamecGMP-gated cation channel alpha-1
Synonyms
  • CNCG
  • CNCG1
  • CNG channel alpha-1
  • CNG-1
  • CNG1
  • Cyclic nucleotide-gated cation channel 1
  • Cyclic nucleotide-gated channel alpha-1
  • Cyclic nucleotide-gated channel, photoreceptor
  • Rod photoreceptor cGMP-gated channel subunit alpha
Gene NameCNGA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009062|cGMP-gated cation channel alpha-1
MKLSMKNNIINTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENP
HARGSFSYKSLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKN
ENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNW
TMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKY
KSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRI
SNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTL
TTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY
MHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIF
ADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSD
GSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGK
QILMKDGLLDLNIANAGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLT
KVEKFLKPLIDTEFSSIEGPGAESGPIDST
Number of residues690
Molecular Weight79584.825
Theoretical pINot Available
GO Classification
Functions
  • intracellular cAMP activated cation channel activity
  • intracellular cGMP activated cation channel activity
  • voltage-gated potassium channel activity
  • cGMP binding
Processes
  • rhodopsin mediated signaling pathway
  • transport
  • visual perception
  • phototransduction, visible light
  • potassium ion transmembrane transport
  • regulation of membrane potential
  • regulation of rhodopsin mediated signaling pathway
Components
  • photoreceptor outer segment membrane
  • plasma membrane
  • integral component of plasma membrane
General FunctionVoltage-gated potassium channel activity
Specific FunctionVisual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Pfam Domain Function
Transmembrane Regions165-185 199-217 242-261 300-322 375-394 479-499
GenBank Protein IDNot Available
UniProtKB IDP29973
UniProtKB Entry NameCNGA1_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0019714|cGMP-gated cation channel alpha-1 (CNGA1)
ATGAAACTATCCATGAAGAACAATATTATCAATACACAGCAGTCTTTTGTAACCATGCCC
AATGTGATTGTACCAGATATTGAAAAGGAAATACGAAGGATGGAAAATGGAGCATGCAGC
TCCTTTTCTGAGGATGATGACAGTGCCTCTACATCTGAAGAATCAGAGAATGAAAACCCT
CATGCAAGGGGTTCCTTTAGTTATAAGTCACTCAGAAAGGGAGGACCATCACAGAGGGAG
CAGTACCTGCCTGGTGCCATTGCACTTTTTAATGTGAACAACAGCAGCAATAAGGACCAG
GAACCAGAAGAAAAAAAGAAAAAGAAAAAAGAAAAGAAGAGCAAGTCAGATGATAAAAAC
GAAAATAAAAACGACCCAGAGAAGAAAAAGAAGAAAAAGGACAAAGAGAAGAAAAAGAAA
GAGGAGAAAAGCAAAGATAAGAAAGAAGAGGAGAAGAAAGAAGTTGTGGTTATTGATCCC
TCGGGAAACACATATTACAACTGGCTGTTTTGCATCACATTACCTGTTATGTACAACTGG
ACAATGGTTATTGCCAGAGCATGTTTTGATGAACTTCAATCTGATTACCTAGAATATTGG
CTCATTTTGGATTACGTATCAGACATAGTCTATTTAATCGATATGTTTGTACGAACAAGG
ACAGGTTACCTAGAACAAGGACTGCTGGTAAAGGAAGAACTTAAACTCATAAATAAATAT
AAATCCAACTTGCAATTTAAACTTGATGTTCTGTCACTGATACCAACTGATTTGCTGTAT
TTTAAGTTAGGGTGGAACTATCCAGAAATTAGATTAAACAGGTTGTTACGGTTCTCTCGT
ATGTTTGAGTTCTTCCAGAGAACAGAAACAAGGACAAACTATCCAAACATCTTCAGGATT
TCCAACCTTGTTATGTATATCGTCATCATTATCCACTGGAATGCATGTGTGTTCTACTCT
ATTTCTAAAGCTATTGGATTTGGAAATGATACATGGGTCTACCCTGATATTAATGATCCT
GAATTTGGCCGTTTGGCTAGAAAATACGTATACAGCCTTTACTGGTCTACACTGACTTTG
ACTACCATTGGTGAAACACCCCCTCCCGTGAGGGATTCTGAGTATGTCTTTGTGGTGGTT
GATTTCCTAATTGGAGTGTTAATTTTTGCTACCATCGTTGGTAACATAGGTTCTATGATT
TCCAACATGAATGCAGCCAGAGCAGAATTTCAAGCAAGAATTGATGCTATCAAGCAATAT
ATGCATTTTCGAAATGTAAGCAAAGATATGGAAAAGAGGGTTATTAAATGGTTTGACTAC
CTGTGGACCAACAAAAAAACAGTTGATGAGAAAGAAGTCTTAAAGTATCTACCTGATAAA
CTAAGAGCAGAAATTGCCATCAACGTTCACTTAGACACATTAAAAAAGGTACGCATTTTT
GCTGATTGTGAAGCTGGTCTGTTGGTGGAGTTGGTCTTGAAATTGCAACCCCAAGTCTAC
AGTCCTGGAGATTATATTTGCAAGAAAGGGGATATCGGACGAGAGATGTACATTATCAAG
GAAGGCAAACTCGCTGTGGTGGCAGATGATGGAGTCACTCAGTTTGTGGTATTGAGCGAT
GGCAGCTACTTCGGTGAGATCAGCATTCTTAACATTAAAGGGAGCAAAGCTGGCAATCGA
AGAACGGCCAATATTAAAAGTATTGGCTACTCAGACCTGTTCTGTCTCTCAAAAGATGAC
CTCATGGAAGCTCTAACTGAGTACCCAGATGCCAAAACTATGCTGGAAGAGAAAGGGAAG
CAGATTTTAATGAAAGATGGTCTACTGGATCTAAACATTGCAAATGCTGGCAGTGATCCT
AAAGATCTTGAAGAGAAGGTTACTCGAATGGAGGGGTCAGTAGACCTCCTGCAAACCAGG
TTTGCCCGAATCTTGGCTGAGTATGAGTCCATGCAGCAGAAACTGAAACAAAGATTAACC
AAGGTTGAGAAATTTCTGAAACCGCTTATTGACACAGAATTTTCAAGTATTGAGGGACCT
GGAGCGGAAAGTGGGCCCATCGACTCTACATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2148
Chromosome Location4
LocusNot Available
References
  1. Pittler SJ, Lee AK, Altherr MR, Howard TA, Seldin MF, Hurwitz RL, Wasmuth JJ, Baehr W: Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel. J Biol Chem. 1992 Mar 25;267(9):6257-62. 1372902
  2. Dhallan RS, Macke JP, Eddy RL, Shows TB, Reed RR, Yau KW, Nathans J: Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression. J Neurosci. 1992 Aug;12(8):3248-56. 1379636
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