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NamePeroxiredoxin-5, mitochondrial
Synonyms
  • 1.11.1.15
  • ACR1
  • Alu corepressor 1
  • Antioxidant enzyme B166
  • AOEB166
  • Liver tissue 2D-page spot 71B
  • Peroxiredoxin V
  • Peroxisomal antioxidant enzyme
  • PLP
  • Prx-V
  • Thioredoxin peroxidase PMP20
  • Thioredoxin reductase
  • TPx type VI
Gene NamePRDX5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037099|Peroxiredoxin-5, mitochondrial
MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAMAPIKVGD
AIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGV
QVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKR
FSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL
Number of residues214
Molecular Weight22086.245
Theoretical pI8.77
GO Classification
Functions
  • peroxiredoxin activity
  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process
  • peroxynitrite reductase activity
  • RNA polymerase III regulatory region DNA binding
  • antioxidant activity
  • peroxidase activity
  • receptor binding
  • protein dimerization activity
Processes
  • hydrogen peroxide catabolic process
  • response to oxidative stress
  • response to reactive oxygen species
  • inflammatory response
  • negative regulation of oxidoreductase activity
  • gene expression
  • NADPH oxidation
  • transcription initiation from RNA polymerase II promoter
  • cellular response to reactive oxygen species
  • negative regulation of transcription from RNA polymerase III promoter
  • reactive nitrogen species metabolic process
  • apoptotic process
  • regulation of apoptosis involved in tissue homeostasis
  • negative regulation of apoptotic process
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • positive regulation of collagen biosynthetic process
Components
  • extracellular space
  • cytoplasmic vesicle
  • peroxisome
  • cytosol
  • extracellular exosome
  • cytoplasm
  • perinuclear region of cytoplasm
  • mitochondrion
  • intracellular membrane-bounded organelle
  • nucleus
  • mitochondrial matrix
  • peroxisomal matrix
General FunctionRna polymerase iii regulatory region dna binding
Specific FunctionReduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID6523289
UniProtKB IDP30044
UniProtKB Entry NamePRDX5_HUMAN
Cellular LocationMitochondrion
Gene sequence
>lcl|BSEQ0016248|Peroxiredoxin-5, mitochondrial (PRDX5)
ATGGGACTAGCTGGCGTGTGCGCCCTGAGACGCTCAGCGGGCTATATACTCGTCGGTGGG
GCCGGCGGTCAGTCTGCGGCAGCGGCAGCAAGACGGTGCAGTGAAGGAGAGTGGGCGTCT
GGCGGGGTCCGCAGTTTCAGCAGAGCCGCTGCAGCCATGGCCCCAATCAAGGTGGGAGAT
GCCATCCCAGCAGTGGAGGTGTTTGAAGGGGAGCCAGGGAACAAGGTGAACCTGGCAGAG
CTGTTCAAGGGCAAGAAGGGTGTGCTGTTTGGAGTTCCTGGGGCCTTCACCCCTGGATGT
TCCAAGACACACCTGCCAGGGTTTGTGGAGCAGGCTGAGGCTCTGAAGGCCAAGGGAGTC
CAGGTGGTGGCCTGTCTGAGTGTTAATGATGCCTTTGTGACTGGCGAGTGGGGCCGAGCC
CACAAGGCGGAAGGCAAGGTTCGGCTCCTGGCTGATCCCACTGGGGCCTTTGGGAAGGAG
ACAGACTTATTACTAGATGATTCGCTGGTGTCCATCTTTGGGAATCGACGTCTCAAGAGG
TTCTCCATGGTGGTACAGGATGGCATAGTGAAGGCCCTGAATGTGGAACCAGATGGCACA
GGCCTCACCTGCAGCCTGGCACCCAATATCATCTCACAGCTCTGA
GenBank Gene IDAJ249483
GeneCard IDNot Available
GenAtlas IDPRDX5
HGNC IDHGNC:9355
Chromosome Location11
Locus11q13
References
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  2. Yamashita H, Avraham S, Jiang S, London R, Van Veldhoven PP, Subramani S, Rogers RA, Avraham H: Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. J Biol Chem. 1999 Oct 15;274(42):29897-904. 10514471
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