NameSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Synonyms
  • PP2A subunit A isoform PR65-beta
  • PP2A subunit A isoform R1-beta
Gene NamePPP2R1B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009188|Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR
SELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA
VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQ
QFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC
VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ
NLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV
IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAI
VELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK
LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKM
AGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLAL
A
Number of residues601
Molecular Weight66212.77
Theoretical pINot Available
GO Classification
Functions
  • protein phosphatase type 2A regulator activity
Processes
  • apoptotic process involved in morphogenesis
  • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • protein complex assembly
Components
  • membrane raft
  • extracellular exosome
General FunctionProtein phosphatase type 2a regulator activity
Specific FunctionThe PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP30154
UniProtKB Entry Name2AAB_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0013660|Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)
ATGGCGGGCGCATCAGAGCTCGGGACCGGCCCAGGAGCAGCGGGTGGAGATGGAGATGAT
TCGCTATACCCGATCGCGGTTTTAATCGACGAGCTCCGCAATGAAGACGTGCAGCTCCGA
CTCAACAGTATTAAGAAGTTATCAACAATTGCCCTAGCACTTGGAGTAGAAAGGACCCGA
AGTGAATTGTTGCCATTTCTTACAGATACAATTTATGATGAAGATGAGGTACTATTAGCT
CTTGCTGAGCAGCTGGGAAATTTCACTGGCCTAGTGGGAGGTCCTGACTTTGCCCACTGT
CTGCTGCCTCCTTTGGAAAATCTGGCAACTGTGGAAGAGACTGTTGTTCGTGACAAGGCT
GTGGAGTCCCTGAGACAGATCTCCCAGGAGCATACTCCTGTTGCTCTGGAAGCTTATTTT
GTACCTCTGGTGAAACGCTTAGCAAGTGGGGATTGGTTCACCTCTCGCACATCTGCATGT
GGTTTGTTCAGCGTTTGCTATCCCAGGGCATCAAATGCTGTTAAAGCAGAAATCAGACAG
CAATTCCGTTCCTTGTGCTCAGATGACACACCAATGGTACGACGTGCTGCTGCTTCCAAA
TTGGGTGAATTTGCAAAAGTTTTGGAATTAGACAGTGTGAAAAGTGAAATTGTTCCACTG
TTCACTAGTCTAGCTTCAGATGAACAGGATTCAGTGCGCCTCCTTGCTGTGGAAGCTTGT
GTCAGTATTGCCCAGTTATTGTCTCAGGATGACCTTGAGACTTTGGTGATGCCTACACTT
CGACAAGCAGCAGAAGATAAATCTTGGCGCGTTCGCTATATGGTGGCTGACAGATTTTCA
GAGCTCCAGAAAGCCATGGGTCCTAAAATCACCCTAAATGACCTCATCCCCGCCTTTCAG
AACCTACTTAAAGACTGTGAAGCTGAAGTCCGGGCAGCTGCTGCCCACAAAGTAAAAGAA
CTTGGTGAGAACTTGCCCATTGAAGATAGAGAGACCATAATTATGAATCAAATTCTGCCT
TATATAAAGTGTCCTGACGTTCGTTTGAATATCATCTCCAATTTGGATTGTGTAAATGAA
GTGATTGGAATCCGTCAGCTCTCTCAGTCTCTCCTTCCTGCCATAGTGGAGCTGGCAGAA
GATGCCAAATGGAGGGTCCGCCTGGCCATCATTGAGTATATGCCGCTGCTGGCAGGCCAG
CTGGGTGTGGAATTCTTTGATGAAAAGCTGAATTCTTTATGTATGGCTTGGCTCGTGGAC
CATGTATACGCCATCCGAGAAGCTGCCACCAACAACCTCATGAAACTAGTTCAGAAGTTT
GGTACAGAGTGGGCCCAAAATACTATTGTTCCCAAAGTGTTAGTAATGGCAAATGATCCT
AATTACTTGCATAGAATGACCACTTTATTCTGCATTAATGCACTGTCTGAGGCCTGTGGT
CAGGAAATAACTACTAAGCAAATGCTGCCCATCGTATTAAAAATGGCAGGAGACCAAGTA
GCAAATGTTCGCTTCAATGTGGCCAAATCTCTACAAAAGATTGGACCAATTCTAGATACC
AATGCTTTACAGGGAGAAGTGAAGCCAGTACTACAGAAGTTAGGTCAAGATGAAGACATG
GATGTCAAATACTTTGCACAGGAAGCTATAAGTGTTCTTGCATTGGCATAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9303
Chromosome Location11
LocusNot Available
References
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