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NameAdenosine receptor A1
SynonymsNot Available
Gene NameADORA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000026|Adenosine receptor A1
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
Number of residues326
Molecular Weight36511.325
Theoretical pI8.75
GO Classification
Functions
  • phospholipase C activity
  • purine nucleoside binding
  • G-protein coupled adenosine receptor activity
Processes
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • positive regulation of potassium ion transport
  • inflammatory response
  • lipid catabolic process
  • negative regulation of blood pressure
  • positive regulation of protein dephosphorylation
  • negative regulation of acute inflammatory response
  • negative regulation of cardiac muscle contraction
  • regulation of glomerular filtration
  • cell-cell signaling
  • negative regulation of circadian sleep/wake cycle, non-REM sleep
  • protein targeting to membrane
  • negative regulation of glutamate secretion
  • negative regulation of hormone secretion
  • relaxation of vascular smooth muscle
  • activation of MAPKK activity
  • negative regulation of leukocyte migration
  • apoptotic signaling pathway
  • negative regulation of apoptotic process
  • negative regulation of lipid catabolic process
  • negative regulation of renal sodium excretion
  • negative regulation of cell proliferation
  • negative regulation of long term synaptic depression
  • positive regulation of blood pressure
  • response to hypoxia
  • negative regulation of mucus secretion
  • negative regulation of neurotrophin production
  • negative regulation of synaptic transmission, glutamatergic
  • negative regulation of vasodilation
  • regulation of respiratory gaseous exchange by neurological system process
  • nervous system development
  • phagocytosis
  • signal transduction
  • regulation of sensory perception of pain
  • positive regulation of epidermal growth factor-activated receptor activity
  • regulation of synaptic plasticity
  • cognition
  • positive regulation of nucleoside transport
  • detection of temperature stimulus involved in sensory perception of pain
  • temperature homeostasis
  • negative regulation of synaptic transmission, GABAergic
  • positive regulation of peptide secretion
  • excitatory postsynaptic potential
Components
  • neuronal cell body
  • presynaptic membrane
  • integral component of plasma membrane
  • axolemma
  • asymmetric synapse
  • dendritic spine
  • basolateral plasma membrane
  • presynaptic active zone
  • terminal bouton
  • postsynaptic density
  • postsynaptic membrane
  • endoplasmic reticulum
  • plasma membrane
General FunctionPurine nucleoside binding
Specific FunctionReceptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Pfam Domain Function
Transmembrane Regions11-33 47-69 81-102 124-146 177-201 236-259 268-292
GenBank Protein ID256155
UniProtKB IDP30542
UniProtKB Entry NameAA1R_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010133|Adenosine receptor A1 (ADORA1)
ATGCCGCCCTCCATCTCAGCTTTCCAGGCCGCCTACATCGGCATCGAGGTGCTCATCGCC
CTGGTCTCTGTGCCCGGGAACGTGCTGGTGATCTGGGCGGTGAAGGTGAACCAGGCGCTG
CGGGATGCCACCTTCTGCTTCATCGTGTCGCTGGCGGTGGCTGATGTGGCCGTGGGTGCC
CTGGTCATCCCCCTCGCCATCCTCATCAACATTGGGCCACAGACCTACTTCCACACCTGC
CTCATGGTTGCCTGTCCGGTCCTCATCCTCACCCAGAGCTCCATCCTGGCCCTGCTGGCA
ATTGCTGTGGACCGCTACCTCCGGGTCAAGATCCCTCTCCGGTACAAGATGGTGGTGACC
CCCCGGAGGGCGGCGGTGGCCATAGCCGGCTGCTGGATCCTCTCCTTCGTGGTGGGACTG
ACCCCTATGTTTGGCTGGAACAATCTGAGTGCGGTGGAGCGGGCCTGGGCAGCCAACGGC
AGCATGGGGGAGCCCGTGATCAAGTGCGAGTTCGAGAAGGTCATCAGCATGGAGTACATG
GTCTACTTCAACTTCTTTGTGTGGGTGCTGCCCCCGCTTCTCCTCATGGTCCTCATCTAC
CTGGAGGTCTTCTACCTAATCCGCAAGCAGCTCAACAAGAAGGTGTCGGCCTCCTCCGGC
GACCCGCAGAAGTACTATGGGAAGGAGCTGAAGATCGCCAAGTCGCTGGCCCTCATCCTC
TTCCTCTTTGCCCTCAGCTGGCTGCCTTTGCACATCCTCAACTGCATCACCCTCTTCTGC
CCGTCCTGCCACAAGCCCAGCATCCTTACCTACATTGCCATCTTCCTCACGCACGGCAAC
TCGGCCATGAACCCCATTGTCTATGCCTTCCGCATCCAGAAGTTCCGCGTCACCTTCCTT
AAGATTTGGAATGACCATTTCCGCTGCCAGCCTGCACCTCCCATTGACGAGGATCTCCCA
GAAGAGAGGCCTGATGACTAG
GenBank Gene IDS45235
GeneCard IDNot Available
GenAtlas IDADORA1
HGNC IDHGNC:262
Chromosome Location1
Locus1q32.1
References
  1. Libert F, Van Sande J, Lefort A, Czernilofsky A, Dumont JE, Vassart G, Ensinger HA, Mendla KD: Cloning and functional characterization of a human A1 adenosine receptor. Biochem Biophys Res Commun. 1992 Sep 16;187(2):919-26. 1530647
  2. Townsend-Nicholson A, Shine J: Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA. Brain Res Mol Brain Res. 1992 Dec;16(3-4):365-70. 1339301
  3. Ren H, Stiles GL: Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. J Biol Chem. 1994 Jan 28;269(4):3104-10. 8300646
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