Neurotensin receptor type 1

NameNeurotensin receptor type 1
Synonyms
  • High-affinity levocabastine-insensitive neurotensin receptor
  • NT-R-1
  • NTRH
  • NTRR
Gene NameNTSR1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013691|Neurotensin receptor type 1
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
Number of residues418
Molecular Weight46258.305
Theoretical pINot Available
GO Classification
Functions
  • G-protein coupled receptor activity
  • G-protein coupled neurotensin receptor activity
Processes
  • G-protein coupled receptor signaling pathway
  • positive regulation of release of sequestered calcium ion into cytosol
  • D-aspartate import
  • regulation of membrane depolarization
  • learning
  • regulation of respiratory gaseous exchange
  • positive regulation of glutamate secretion
  • inositol phosphate catabolic process
  • detection of temperature stimulus involved in sensory perception of pain
  • L-glutamate import into cell
  • regulation of sensory perception of pain
  • neuropeptide signaling pathway
  • negative regulation of release of sequestered calcium ion into cytosol
  • temperature homeostasis
  • synaptic transmission
  • negative regulation of systemic arterial blood pressure
  • positive regulation of arachidonic acid secretion
  • positive regulation of inhibitory postsynaptic potential
  • positive regulation of gamma-aminobutyric acid secretion
  • positive regulation of inositol phosphate biosynthetic process
  • regulation of action potential
  • adult locomotory behavior
  • positive regulation of apoptotic process
  • response to lipid
  • positive regulation of cation channel activity
  • negative regulation of apoptotic process
Components
  • cytoplasmic side of plasma membrane
  • membrane raft
  • dendritic shaft
  • perikaryon
  • mitochondrion
  • symmetric synapse
  • dendritic spine
  • terminal bouton
  • endoplasmic reticulum
  • plasma membrane
  • cell surface
  • Golgi apparatus
  • integral component of plasma membrane
General FunctionG-protein coupled receptor activity
Specific FunctionG-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197).
Pfam Domain Function
Transmembrane Regions68-88 103-122 143-164 185-205 235-259 304-325 344-364
GenBank Protein IDNot Available
UniProtKB IDP30989
UniProtKB Entry NameNTR1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013692|Neurotensin receptor type 1 (NTSR1)
ATGCGCCTCAACAGCTCCGCGCCGGGAACCCCGGGCACGCCGGCCGCCGACCCCTTCCAG
CGGGCGCAGGCCGGACTGGAGGAGGCGCTGCTGGCCCCGGGCTTCGGCAACGCTTCGGGC
AACGCGTCGGAGCGCGTCCTGGCGGCACCCAGCAGCGAGCTGGACGTGAACACCGACATC
TACTCCAAGGTGCTGGTGACCGCCGTGTACCTGGCGCTCTTCGTGGTGGGCACGGTGGGC
AACACGGTGACGGCGTTCACGCTGGCGCGGAAGAAGTCGCTGCAGAGCCTGCAGAGCACG
GTGCATTACCACCTGGGCAGCCTGGCGCTGTCCGACCTGCTCACCCTGCTGCTGGCCATG
CCCGTGGAGCTGTACAACTTCATCTGGGTGCACCACCCCTGGGCCTTCGGCGACGCCGGC
TGCCGCGGCTACTACTTCCTGCGCGACGCCTGCACCTACGCCACGGCCCTCAACGTGGCC
AGCCTGAGTGTGGAGCGCTACCTGGCCATCTGCCACCCCTTCAAGGCCAAGACCCTCATG
TCCCGAAGCCGCACCAAGAAGTTCATCAGCGCCATCTGGCTCGCCTCGGCCCTGCTGGCG
GTGCCTATGCTGTTCACCATGGGCGAGCAGAACCGCAGCGCCGACGGCCAGCACGCCGGC
GGCCTGGTGTGCACCCCCACCATCCACACTGCCACCGTCAAGGTCGTCATACAGGTCAAC
ACCTTCATGTCCTTCATATTCCCCATGGTGGTCATCTCGGTCCTGAACACCATCATCGCC
AACAAGCTGACCGTCATGGTACGCCAGGCGGCCGAGCAGGGCCAAGTGTGCACGGTCGGG
GGCGAGCACAGCACATTCAGCATGGCCATCGAGCCTGGCAGGGTCCAGGCCCTGCGGCAC
GGCGTGCGCGTCCTACGTGCAGTGGTCATCGCCTTTGTGGTCTGCTGGCTGCCCTACCAC
GTGCGGCGCCTCATGTTCTGCTACATCTCGGATGAGCAGTGGACTCCGTTCCTCTATGAC
TTCTACCACTACTTCTACATGGTGACCAACGCACTCTTCTACGTCAGCTCCACCATCAAC
CCCATCCTGTACAACCTCGTCTCTGCCAACTTCCGCCACATCTTCCTGGCCACACTGGCC
TGCCTCTGCCCGGTGTGGCGGCGCAGGAGGAAGAGGCCAGCCTTCTCGAGGAAGGCCGAC
AGCGTGTCCAGCAACCACACCCTCTCCAGCAATGCCACCCGCGAGACGCTGTACTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:8039
Chromosome Location20
LocusNot Available
References
  1. Vita N, Laurent P, Lefort S, Chalon P, Dumont X, Kaghad M, Gully D, Le Fur G, Ferrara P, Caput D: Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. FEBS Lett. 1993 Feb 8;317(1-2):139-42. 8381365
  2. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. 11780052
  3. Swift SL, Burns JE, Maitland NJ: Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. Cancer Res. 2010 Jan 1;70(1):347-56. doi: 10.1158/0008-5472.CAN-09-1252. 20048080
  4. Heakal Y, Woll MP, Fox T, Seaton K, Levenson R, Kester M: Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains. Cancer Biol Ther. 2011 Sep 1;12(5):427-35. Epub 2011 Sep 1. 21725197
  5. Da Costa G, Bondon A, Coutant J, Curmi P, Monti JP: Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor. J Biomol Struct Dyn. 2013 Dec;31(12):1381-92. doi: 10.1080/07391102.2012.736776. Epub 2012 Nov 12. 23140271