NameBifunctional protein PyrR
Synonyms
  • 2.4.2.9
  • UPRTase
Gene NamepyrR
OrganismBacillus caldolyticus
Amino acid sequence
>lcl|BSEQ0016504|Bifunctional protein PyrR
MQKAVVMDEQAIRRALTRIAHEIIERNKGIDGCVLVGIKTRGIYLARRLAERIEQIEGAS
VPVGELDITLYRDDLTVKTDDHEPLVKGTNVPFPVTERNVILVDDVLFTGRTVRAAMDAV
MDLGRPARIQLAVLVDRGHRELPIRADFVGKNVPTSRSELIVVELSEVDGIDQVSIHEK
Number of residues179
Molecular Weight19937.85
Theoretical pI5.71
GO Classification
Functions
  • RNA binding
  • uracil phosphoribosyltransferase activity
Processes
  • regulation of transcription, DNA-templated
  • DNA-templated transcription, termination
  • nucleoside metabolic process
General FunctionUracil phosphoribosyltransferase activity
Specific FunctionRegulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable).Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID431230
UniProtKB IDP41007
UniProtKB Entry NamePYRR_BACCL
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0003240|540 bp
ATGCAAAAGGCGGTCGTGATGGACGAACAGGCGATTCGCCGCGCTTTGACGCGCATCGCC
CACGAAATCATCGAACGAAACAAAGGCATTGACGGCTGCGTGCTTGTCGGAATTAAAACG
CGCGGCATTTACTTGGCGCGCCGCTTGGCGGAGCGGATCGAGCAAATTGAAGGGGCGTCC
GTTCCCGTCGGTGAGCTTGACATCACCTTGTACCGCGACGATTTGACCGTGAAGACGGAC
GACCATGAACCGCTTGTGAAAGGAACGAATGTGCCGTTTCCGGTGACCGAGCGGAATGTC
ATTTTAGTTGATGACGTGCTCTTCACCGGCCGGACGGTGCGGGCGGCGATGGATGCGGTC
ATGGATTTGGGCCGCCCGGCGCGCATCCAGCTCGCCGTGCTTGTTGACCGCGGCCACAGG
GAACTCCCGATCCGCGCTGATTTCGTCGGCAAAAACGTGCCGACCTCTCGTTCGGAACTG
ATCGTCGTGGAGCTTTCGGAAGTGGACGGCATCGATCAAGTCTCCATTCATGAAAAATAG
GenBank Gene IDX76083
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Ghim SY, Neuhard J: The pyrimidine biosynthesis operon of the thermophile Bacillus caldolyticus includes genes for uracil phosphoribosyltransferase and uracil permease. J Bacteriol. 1994 Jun;176(12):3698-707. 8206848