Prostaglandin-H2 D-isomerase

NameProstaglandin-H2 D-isomerase
Synonyms
  • 5.3.99.2
  • Beta-trace protein
  • Cerebrin-28
  • Glutathione-independent PGD synthase
  • Lipocalin-type prostaglandin-D synthase
  • PDS
  • PGD2 synthase
  • PGDS
  • PGDS2
  • Prostaglandin-D2 synthase
Gene NamePTGDS
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017847|Prostaglandin-H2 D-isomerase
MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKA
ALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSV
VETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFL
PQTDKCMTEQ
Number of residues190
Molecular Weight21028.665
Theoretical pINot Available
GO Classification
Functions
  • fatty acid binding
  • transporter activity
  • prostaglandin-D synthase activity
  • retinoid binding
Processes
  • small molecule metabolic process
  • response to glucocorticoid
  • arachidonic acid metabolic process
  • cyclooxygenase pathway
  • prostaglandin biosynthetic process
  • transport
  • regulation of circadian sleep/wake cycle, sleep
  • negative regulation of male germ cell proliferation
Components
  • extracellular space
  • endoplasmic reticulum membrane
  • Golgi apparatus
  • extracellular exosome
  • nuclear membrane
  • perinuclear region of cytoplasm
  • rough endoplasmic reticulum
  • extracellular region
General FunctionTransporter activity
Specific FunctionCatalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP41222
UniProtKB Entry NamePTGDS_HUMAN
Cellular LocationRough endoplasmic reticulum
Gene sequence
>lcl|BSEQ0017848|Prostaglandin-H2 D-isomerase (PTGDS)
ATGGCTACTCATCACACGCTGTGGATGGGACTGGCCCTGCTGGGGGTGCTGGGCGACCTG
CAGGCAGCACCGGAGGCCCAGGTCTCCGTGCAGCCCAACTTCCAGCAGGACAAGTTCCTG
GGGCGCTGGTTCAGCGCGGGCCTCGCCTCCAACTCGAGCTGGCTCCGGGAGAAGAAGGCG
GCGTTGTCCATGTGCAAGTCTGTGGTGGCCCCTGCCACGGATGGTGGCCTCAACCTGACC
TCCACCTTCCTCAGGAAAAACCAGTGTGAGACCCGAACCATGCTGCTGCAGCCCGCGGGG
TCCCTCGGCTCCTACAGCTACCGGAGTCCCCACTGGGGCAGCACCTACTCCGTGTCAGTG
GTGGAGACCGACTACGACCAGTACGCGCTGCTGTACAGCCAGGGCAGCAAGGGCCCTGGC
GAGGACTTCCGCATGGCCACCCTCTACAGCCGAACCCAGACCCCCAGGGCTGAGTTAAAG
GAGAAATTCACCGCCTTCTGCAAGGCCCAGGGCTTCACAGAGGATACCATTGTCTTCCTG
CCCCAAACCGATAAGTGCATGACGGAACAATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9592
Chromosome Location9
LocusNot Available
References
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