Catalase

NameCatalase
Synonyms
  • 1.11.1.6
Gene NamekatA
OrganismProteus mirabilis
Amino acid sequence
>lcl|BSEQ0016639|Catalase
MEKKKLTTAAGAPVVDNNNVITAGPRGPMLLQDVWFLEKLAHFDREVIPERRMHAKGSGA
FGTFTVTHDITKYTRAKIFSEVGKKTEMFARFSTVAGERGAADAERDIRGFALKFYTEEG
NWDMVGNNTPVFYLRDPLKFPDLNHIVKRDPRTNMRNMAYKWDFFSHLPESLHQLTIDMS
DRGLPLSYRFVHGFGSHTYSFINKDNERFWVKFHFRCQQGIKNLMDDEAEALVGKDRESS
QRDLFEAIERGDYPRWKLQIQIMPEKEASTVPYNPFDLTKVWPHADYPLMDVGYFELNRN
PDNYFSDVEQAAFSPANIVPGISFSPDKMLQGRLFSYGDAHRYRLGVNHHQIPVNAPKCP
FHNYHRDGAMRVDGNSGNGITYEPNSGGVFQEQPDFKEPPLSIEGAADHWNHREDEDYFS
QPRALYELLSDDEHQRMFARIAGELSQASKETQQRQIDLFTKVHPEYGAGVEKAIKVLEG
KDAK
Number of residues484
Molecular Weight55614.085
Theoretical pI6.56
GO Classification
Functions
  • catalase activity
  • metal ion binding
  • heme binding
Processes
  • response to oxidative stress
  • hydrogen peroxide catabolic process
Components
  • cytoplasm
General FunctionMetal ion binding
Specific FunctionDecomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP42321
UniProtKB Entry NameCATA_PROMI
Cellular LocationCytoplasm
Gene sequenceNot Available
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Buzy A, Bracchi V, Sterjiades R, Chroboczek J, Thibault P, Gagnon J, Jouve HM, Hudry-Clergeon G: Complete amino acid sequence of Proteus mirabilis PR catalase. Occurrence of a methionine sulfone in the close proximity of the active site. J Protein Chem. 1995 Feb;14(2):59-72. 7786407
  2. Gouet P, Jouve HM, Dideberg O: Crystal structure of Proteus mirabilis PR catalase with and without bound NADPH. J Mol Biol. 1995 Jun 23;249(5):933-54. 7791219
  3. Gouet P, Jouve HM, Williams PA, Andersson I, Andreoletti P, Nussaume L, Hajdu J: Ferryl intermediates of catalase captured by time-resolved Weissenberg crystallography and UV-VIS spectroscopy. Nat Struct Biol. 1996 Nov;3(11):951-6. 8901874
  4. Andreoletti P, Sainz G, Jaquinod M, Gagnon J, Jouve HM: High-resolution structure and biochemical properties of a recombinant Proteus mirabilis catalase depleted in iron. Proteins. 2003 Feb 1;50(2):261-71. 12486720