Ran-specific GTPase-activating protein

NameRan-specific GTPase-activating protein
Synonyms
  • Ran-binding protein 1
  • RanBP1
Gene NameRANBP1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049671|Ran-specific GTPase-activating protein
MAAAKDTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFAS
ENDLPEWKERGTGDVKLLKHKEKGAIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAW
VWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKAGSGKNDHAEKV
AEKLEALSVKEETKEDAEEKQ
Number of residues201
Molecular Weight23309.92
Theoretical pINot Available
GO Classification
Functions
  • GTPase activator activity
  • cadherin binding
  • GDP-dissociation inhibitor activity
  • Ran GTPase binding
Processes
  • RNA export from nucleus
  • signal transduction
  • G1/S transition of mitotic cell cycle
  • viral process
  • ubiquitin-dependent protein catabolic process
  • protein import into nucleus
  • spindle organization
  • positive regulation of mitotic centrosome separation
Components
  • cytoplasm
  • nucleus
  • cytosol
  • nuclear envelope
  • centrosome
General FunctionInhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
Specific FunctionCadherin binding
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP43487
UniProtKB Entry NameRANG_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0049672|Ran-specific GTPase-activating protein (RANBP1)
ATGGCGGCCGCCAAGGACACTCATGAGGACCATGATACTTCCACTGAGAATACAGACGAG
TCCAACCATGACCCTCAGTTTGAGCCAATAGTTTCTCTTCCTGAGCAAGAAATTAAAACA
CTGGAAGAAGATGAAGAGGAACTTTTTAAAATGCGGGCAAAACTGTTCCGATTTGCCTCT
GAGAACGATCTCCCAGAATGGAAGGAGCGAGGCACTGGTGACGTCAAGCTCCTGAAGCAC
AAGGAGAAAGGGGCCATCCGCCTCCTCATGCGGAGGGACAAGACCCTGAAGATCTGTGCC
AACCACTACATCACGCCGATGATGGAGCTGAAGCCCAACGCAGGTAGCGACCGTGCCTGG
GTCTGGAACACCCACGCTGACTTCGCCGACGAGTGCCCCAAGCCAGAGCTGCTGGCCATC
CGCTTCCTGAATGCTGAGAATGCACAGAAATTCAAAACAAAGTTTGAAGAATGCAGGAAA
GAGATCGAAGAGAGAGAAAAGAAAGCAGGATCAGGCAAAAATGATCATGCCGAAAAAGTG
GCGGAAAAGCTAGAAGCTCTCTCGGTGAAGGAGGAGACCAAGGAGGATGCTGAGGAGAAG
CAATAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9847
Chromosome Location22
Locus22q11.21
References
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