NameAlpha-S1-casein
Synonyms
  • CASA
  • CSN1
Gene NameCSN1S1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009177|Alpha-S1-casein
MRLLILTCLVAVALARPKLPLRYPERLQNPSESSEPIPLESREEYMNGMNRQRNILREKQ
TDEIKDTRNESTQNCVVAEPEKMESSISSSSEEMSLSKCAEQFCRLNEYNQLQLQAAHAQ
EQIRRMNENSHVQVPFQQLNQLAAYPYAVWYYPQIMQYVPFPPFSDISNPTAHENYEKNN
VMLQW
Number of residues185
Molecular Weight21671.33
Theoretical pINot Available
GO Classification
Functions
  • transporter activity
Processes
  • transmembrane transport
Components
  • extracellular region
  • extracellular space
General FunctionTransporter activity
Specific FunctionImportant role in the capacity of milk to transport calcium phosphate.Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1 receptors.
Pfam Domain FunctionNot Available
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP47710
UniProtKB Entry NameCASA1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0013653|Alpha-S1-casein (CSN1S1)
ATGAGGCTTCTCATTCTCACCTGTCTTGTGGCTGTTGCTCTTGCCAGGCCTAAACTTCCT
CTTAGATACCCAGAACGCCTTCAGAATCCATCAGAGAGCAGTGAGCCTATACCATTAGAA
TCAAGAGAGGAATACATGAATGGTATGAACAGGAGAAACATTCTGAGAGAAAAACAGACT
GATGAAATCAAGGATACTAGGAATGAGTCTACTCAGAACTGTGTTGTGGCAGAGCCTGAG
AAGATGGAATCCAGCATCAGTTCATCGAGTGAGGAACAGTTTTGTAGACTGAACGAATAC
AACCAACTTCAGCTGCAAGCTGCCCATGCCCAGGAGCAAATTCGCAGAATGAATGAAAAC
AGCCATGTCCAAGTGCCTTTCCAGCAGCTCAACCAACTTGCTGCCTACCCCTATGCTGTT
TGGTACTATCCACAAATCATGCAGTATGTTCCTTTCCCACCGTTTTCCGACATCTCCAAT
CCCACTGCTCATGAAAATTATGAAAAAAATAACGTCATGCTACAGTGGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2445
Chromosome Location4
LocusNot Available
References
  1. Johnsen LB, Rasmussen LK, Petersen TE, Berglund L: Characterization of three types of human alpha s1-casein mRNA transcripts. Biochem J. 1995 Jul 1;309 ( Pt 1):237-42. 7619062
  2. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. 15815621
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  4. Cavaletto M, Cantisani A, Giuffrida G, Napolitano L, Conti A: Human alpha S1-casein like protein: purification and N-terminal sequence determination. Biol Chem Hoppe Seyler. 1994 Feb;375(2):149-51. 8192860
  5. Rasmussen LK, Due HA, Petersen TE: Human alpha s1-casein: purification and characterization. Comp Biochem Physiol B Biochem Mol Biol. 1995 May;111(1):75-81. 7749638
  6. Kjeldsen F, Savitski MM, Nielsen ML, Shi L, Zubarev RA: On studying protein phosphorylation patterns using bottom-up LC-MS/MS: the case of human alpha-casein. Analyst. 2007 Aug;132(8):768-76. Epub 2007 Jun 13. 17646876
  7. Poth AG, Deeth HC, Alewood PF, Holland JW: Analysis of the human casein phosphoproteome by 2-D electrophoresis and MALDI-TOF/TOF MS reveals new phosphoforms. J Proteome Res. 2008 Nov;7(11):5017-27. doi: 10.1021/pr800387s. Epub 2008 Oct 11. 18847231
  8. Sorensen ES, Moller L, Vinther M, Petersen TE, Rasmussen LK: The phosphorylation pattern of human alphas1-casein is markedly different from the ruminant species. Eur J Biochem. 2003 Sep;270(17):3651-5. 12919330
  9. Fujiwara Y, Miwa M, Nogami M, Okumura K, Nobori T, Suzuki T, Ueda M: Genomic organization and chromosomal localization of the human casein gene family. Hum Genet. 1997 Mar;99(3):368-73. 9050925
  10. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. 20068231