Name4-trimethylaminobutyraldehyde dehydrogenase
Synonyms
  • 1.2.1.47
  • Aldehyde dehydrogenase E3 isozyme
  • Aldehyde dehydrogenase family 9 member A1
  • ALDH4
  • ALDH7
  • ALDH9
  • Gamma-aminobutyraldehyde dehydrogenase
  • R-aminobutyraldehyde dehydrogenase
  • TMABADH
Gene NameALDH9A1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000571|4-trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF
Number of residues494
Molecular Weight53801.495
Theoretical pI5.61
GO Classification
Functions
  • 1-pyrroline dehydrogenase activity
  • 4-trimethylammoniobutyraldehyde dehydrogenase activity
  • aminobutyraldehyde dehydrogenase activity
  • aldehyde dehydrogenase (NAD) activity
  • 3-chloroallyl aldehyde dehydrogenase activity
Processes
  • carnitine biosynthetic process
  • hormone metabolic process
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
  • oxidation-reduction process
  • branched-chain amino acid catabolic process
  • neurotransmitter biosynthetic process
  • cellular aldehyde metabolic process
Components
  • cytoplasm
  • mitochondrion
  • cytosol
  • extracellular exosome
General FunctionAminobutyraldehyde dehydrogenase activity
Specific FunctionConverts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1049219
UniProtKB IDP49189
UniProtKB Entry NameAL9A1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010063|4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)
ATGTTTCTCCGAGCAGGCCTGGCCGCGCTCTCCCCGCTTCTTCGCAGTCTTCGGCCCTCT
CCTGTCGCCGCCATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGC
GGGGCCCGCGTGGAGCCGGCGGACGCCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACC
GGCCGAGTGATAGCTACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAA
AATGCAAAGGCTGCTTTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATC
CTTTTGGAGGCTGCCAGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGC
ATCAACAATGGCAAGTCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGC
CTGGAGTATTATGCGGGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGT
GGATCGTTTGGTTATACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGG
AACTACCCCTTTCAGATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCC
ATGGTCTTTAAACCTTCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTAC
AGTGAGGCTGGTGTACCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGC
CAGTTTCTGTGTCAGCATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACT
GGCATGAAGATCATGGAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGA
GGCAAATCTCCACTCATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCG
CTGATGGCCAACTTCCTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTG
CAGAAAGAAATTCTTGATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAA
ATTGGAGATCCCCTTCTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTG
GAGCGAGTCCTTGGGTTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGT
GGAGATATATATGTACCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGT
GTATTAACTAATTGCAGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTT
ATGTCCATTTTATCATTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACT
TTTGGACTAGCAGCTGGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCT
GAGCTTCAGGCTGGGACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCC
TTTGGTGGATATAAGAAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATAT
TATTCACAGCTGAAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA
GenBank Gene IDU34252
GeneCard IDNot Available
GenAtlas IDALDH9A1
HGNC IDHGNC:412
Chromosome Location1
Locus1q23.1
References
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