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NameProtein farnesyltransferase subunit beta
Synonyms
  • 2.5.1.58
  • CAAX farnesyltransferase subunit beta
  • FTase-beta
  • Ras proteins prenyltransferase subunit beta
Gene NameFNTB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004659|Protein farnesyltransferase subunit beta
MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
PGFEELKDETSAEPATD
Number of residues437
Molecular Weight48773.2
Theoretical pI5.67
GO Classification
Functions
  • peptide binding
  • drug binding
  • protein farnesyltransferase activity
  • zinc ion binding
  • isoprenoid binding
  • farnesyltranstransferase activity
Processes
  • wound healing
  • phototransduction, visible light
  • response to cytokine
  • response to organic cyclic compound
  • positive regulation of cell cycle
  • response to inorganic substance
  • positive regulation of nitric-oxide synthase biosynthetic process
  • positive regulation of fibroblast proliferation
  • protein farnesylation
  • regulation of rhodopsin mediated signaling pathway
  • rhodopsin mediated signaling pathway
  • negative regulation of cell proliferation
Components
  • protein farnesyltransferase complex
  • microtubule associated complex
  • cytosol
General FunctionZinc ion binding
Specific FunctionEssential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP49356
UniProtKB Entry NameFNTB_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0016768|Protein farnesyltransferase subunit beta (FNTB)
ATGATCGCAAAAGTAGAAGAAAAGATCCAAGAGGTCTTCAGTTCTTACAAGTTCAACCAC
CTTGTACCAAGGCTTGTTTTGCAGAGGGAGAAGCACTTCCATTATCTGAAAAGAGGCCTT
CGACAACTGACAGATGCCTATGAGTGTCTGGATGCCAGCCGCCCATGGCTCTGCTATTGG
ATCCTGCACAGCTTGGAACTGCTAGATGAACCCATCCCCCAGATAGTGGCTACAGATGTG
TGTCAGTTCCTGGAGCTGTGTCAGAGCCCAGAAGGTGGCTTTGGAGGAGGACCCGGTCAG
TATCCACACCTTGCACCCACATATGCAGCAGTCAATGCATTGTGCATCATTGGCACCGAG
GAGGCCTATGACATCATTAACAGAGAGAAGCTTCTTCAGTATTTGTACTCCCTGAAGCAA
CCTGACGGCTCCTTTCTCATGCATGTCGGAGGTGAGGTGGATGTGAGAAGCGCATACTGT
GCTGCCTCCGTAGCCTCGCTGACCAACATCATCACTCCAGACCTCTTTGAGGGCACTGCT
GAATGGATAGCAAGGTGTCAGAACTGGGAAGGTGGCATTGGCGGGGTACCAGGGATGGAA
GCCCATGGTGGCTATACCTTCTGTGGCCTGGCCGCGCTGGTAATCCTCAAGAGGGAACGT
TCCTTGAACTTGAAGAGCTTATTACAATGGGTGACAAGCCGGCAGATGCGATTTGAAGGA
GGATTTCAGGGCCGCTGCAACAAGCTGGTGGATGGCTGCTACTCCTTCTGGCAGGCGGGG
CTCCTGCCCCTGCTCCACCGCGCACTGCACGCCCAAGGTGACCCTGCCCTTAGCATGAGC
CACTGGATGTTCCATCAGCAGGCCCTGCAGGAGTACATCCTGATGTGCTGCCAGTGCCCT
GCGGGGGGGCTTCTGGATAAACCTGGCAAGTCGCGTGATTTCTACCACACCTGCTACTGC
CTGAGCGGCCTGTCCATAGCCCAGCACTTCGGCAGCGGAGCCATGTTGCATGATGTGGTC
CTGGGTGTGCCCGAAAACGCTCTGCAGCCCACTCACCCAGTGTACAACATTGGACCAGAC
AAGGTGATCCAGGCCACTACATACTTTCTACAGAAGCCAGTCCCAGGTTTTGAGGAGCTT
AAGGATGAGACATCGGCAGAGCCTGCAACCGACTAG
GenBank Gene IDL00635
GeneCard IDNot Available
GenAtlas IDFNTB
HGNC IDHGNC:3785
Chromosome Location14
Locus14q23-q24
References
  1. Omer CA, Kral AM, Diehl RE, Prendergast GC, Powers S, Allen CM, Gibbs JB, Kohl NE: Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases. Biochemistry. 1993 May 18;32(19):5167-76. 8494894
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  5. Andres DA, Milatovich A, Ozcelik T, Wenzlau JM, Brown MS, Goldstein JL, Francke U: cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences. Genomics. 1993 Oct;18(1):105-12. 8276393
  6. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. 17081983
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  8. Long SB, Hancock PJ, Kral AM, Hellinga HW, Beese LS: The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12948-53. Epub 2001 Oct 30. 11687658
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  12. Terry KL, Casey PJ, Beese LS: Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry. 2006 Aug 15;45(32):9746-55. 16893176
  13. Hast MA, Fletcher S, Cummings CG, Pusateri EE, Blaskovich MA, Rivas K, Gelb MH, Van Voorhis WC, Sebti SM, Hamilton AD, Beese LS: Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem Biol. 2009 Feb 27;16(2):181-92. doi: 10.1016/j.chembiol.2009.01.014. 19246009