NameHistamine N-methyltransferase
Synonyms
  • 2.1.1.8
  • HMT
Gene NameHNMT
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004783|Histamine N-methyltransferase
MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIG
GGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETS
SEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWD
KLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLL
WDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
Number of residues292
Molecular Weight33294.765
Theoretical pI4.98
GO Classification
Functions
  • histamine N-methyltransferase activity
Processes
  • response to cocaine
  • brain development
  • response to amine
  • methylation
  • response to interleukin-1
  • respiratory gaseous exchange
  • hyperosmotic response
  • cellular nitrogen compound metabolic process
  • positive regulation of protein targeting to mitochondrion
  • response to tumor cell
  • small molecule metabolic process
  • response to glucocorticoid
  • histidine catabolic process
  • response to immobilization stress
Components
  • cytoplasm
  • cytosol
  • extracellular exosome
  • nucleoplasm
  • neuron projection
General FunctionHistamine n-methyltransferase activity
Specific FunctionInactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Pfam Domain FunctionNot Available
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP50135
UniProtKB Entry NameHNMT_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0011743|Histamine N-methyltransferase (HNMT)
ATGGCATCTTCCATGAGGAGCTTGTTTTCTGACCACGGGAAATATGTTGAATCTTTCCGG
AGGTTTCTCAACCATTCCACGGAACACCAGTGCATGCAGGAATTCATGGACAAGAAGCTG
CCAGGCATAATAGGAAGATACCAGAATTGCTGTTAA
GenBank Gene IDD16224
GeneCard IDNot Available
GenAtlas IDHNMT
HGNC IDHGNC:5028
Chromosome Location2
Locus2q22.1
References
  1. Yamauchi K, Sekizawa K, Suzuki H, Nakazawa H, Ohkawara Y, Katayose D, Ohtsu H, Tamura G, Shibahara S, Takemura M, et al.: Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway. Am J Physiol. 1994 Sep;267(3 Pt 1):L342-9. 7943261
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