Tmic
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NameActin, cytoplasmic 1
Synonyms
  • Beta-actin
Gene NameACTB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021720|Actin, cytoplasmic 1
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Number of residues375
Molecular Weight41736.37
Theoretical pINot Available
GO Classification
Functions
  • ATP binding
  • identical protein binding
  • kinesin binding
  • structural constituent of cytoskeleton
  • nitric-oxide synthase binding
  • Tat protein binding
Processes
  • ephrin receptor signaling pathway
  • substantia nigra development
  • axon guidance
  • retina homeostasis
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • innate immune response
  • chromatin organization
  • adherens junction organization
  • 'de novo' posttranslational protein folding
  • cell junction assembly
  • cellular protein metabolic process
  • blood coagulation
  • cell-cell junction organization
  • vascular endothelial growth factor receptor signaling pathway
  • ATP-dependent chromatin remodeling
  • membrane organization
  • protein folding
  • platelet aggregation
  • small GTPase mediated signal transduction
  • movement of cell or subcellular component
Components
  • nuclear chromatin
  • myelin sheath
  • nucleoplasm
  • cytoplasm
  • membrane
  • protein complex
  • cortical cytoskeleton
  • ribonucleoprotein complex
  • cytoskeleton
  • plasma membrane
  • extracellular space
  • blood microparticle
  • MLL5-L complex
  • dense body
  • cytoplasmic ribonucleoprotein granule
  • NuA4 histone acetyltransferase complex
  • cytosol
  • focal adhesion
  • extracellular exosome
General FunctionTat protein binding
Specific FunctionActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP60709
UniProtKB Entry NameACTB_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021721|Actin, cytoplasmic 1 (ACTB)
ATGGATGATGATATCGCCGCGCTCGTCGTCGACAACGGCTCCGGCATGTGCAAGGCCGGC
TTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCAC
CAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCCTATGTGGGCGACGAGGCCCAGAGC
AAGAGAGGCATCCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGAC
GACATGGAGAAAATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCCGAGGAG
CACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACC
CAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTTGCTATCCAGGCTGTGCTA
TCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACC
CACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTG
GCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACCGAGCGCGGCTACAGCTTC
ACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTACGTCGCC
CTGGACTTCGAGCAAGAGATGGCCACGGCTGCTTCCAGCTCCTCCCTGGAGAAGAGCTAC
GAGCTGCCTGACGGCCAGGTCATCACCATTGGCAATGAGCGGTTCCGCTGCCCTGAGGCA
CTCTTCCAGCCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAAC
TCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCCAACACAGTGCTGTCT
GGCGGCACCACCATGTACCCTGGCATTGCCGACAGGATGCAGAAGGAGATCACTGCCCTG
GCACCCAGCACAATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCCGTGTGG
ATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAG
GAGTATGACGAGTCCGGCCCCTCCATCGTCCACCGCAAATGCTTCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:132
Chromosome Location7
LocusNot Available
References
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