Cell division control protein 42 homolog

NameCell division control protein 42 homolog
Synonyms
  • G25K GTP-binding protein
Gene NameCDC42
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009537|Cell division control protein 42 homolog
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG
QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR
DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP
EPKKSRRCVLL
Number of residues191
Molecular Weight21258.42
Theoretical pINot Available
GO Classification
Functions
  • protein kinase binding
  • GTP binding
  • ubiquitin protein ligase activity
  • GTPase activity
  • identical protein binding
  • apolipoprotein A-I receptor binding
  • thioesterase binding
Processes
  • sprouting angiogenesis
  • actin filament branching
  • positive regulation of cell growth
  • positive regulation of substrate adhesion-dependent cell spreading
  • ephrin receptor signaling pathway
  • cardiac conduction system development
  • negative regulation of epidermal growth factor receptor signaling pathway
  • actin cytoskeleton organization
  • macrophage differentiation
  • dendritic cell migration
  • positive regulation of intracellular protein transport
  • establishment or maintenance of cell polarity
  • axon guidance
  • substantia nigra development
  • epithelial cell-cell adhesion
  • positive regulation of DNA replication
  • regulation of small GTPase mediated signal transduction
  • epidermal growth factor receptor signaling pathway
  • epithelial-mesenchymal cell signaling
  • heart contraction
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • keratinocyte development
  • establishment or maintenance of apical/basal cell polarity
  • innate immune response
  • positive regulation of cytokinesis
  • canonical Wnt signaling pathway
  • neuron fate determination
  • Golgi organization
  • muscle cell differentiation
  • hair follicle morphogenesis
  • hair follicle placode formation
  • positive regulation of hair follicle cell proliferation
  • positive regulation of phosphatidylinositol 3-kinase activity
  • positive regulation of synapse structural plasticity
  • positive regulation of muscle cell differentiation
  • positive regulation of epithelial cell proliferation involved in lung morphogenesis
  • positive regulation of metalloenzyme activity
  • nuclear migration
  • positive regulation of neuron apoptotic process
  • regulation of protein catabolic process
  • positive regulation of pseudopodium assembly
  • blood coagulation
  • positive regulation of gene expression
  • filopodium assembly
  • regulation of attachment of spindle microtubules to kinetochore
  • actin filament bundle assembly
  • multicellular organism growth
  • regulation of protein stability
  • adherens junction organization
  • regulation of filopodium assembly
  • negative regulation of protein complex assembly
  • keratinization
  • regulation of protein heterodimerization activity
  • protein ubiquitination
  • negative regulation of gene expression
  • T cell costimulation
  • positive regulation of peptidyl-serine phosphorylation
  • establishment of Golgi localization
  • submandibular salivary gland formation
  • small GTPase mediated signal transduction
  • regulation of mitotic nuclear division
  • vascular endothelial growth factor receptor signaling pathway
  • organelle transport along microtubule
  • regulation of protein kinase activity
  • positive regulation of JNK cascade
  • cellular protein localization
Components
  • extracellular exosome
  • myelin sheath
  • neuron projection
  • filopodium
  • spindle midzone
  • microtubule organizing center
  • cytoplasm
  • cytoplasmic ribonucleoprotein granule
  • membrane
  • focal adhesion
  • neuronal cell body
  • secretory granule
  • mitotic spindle
  • midbody
  • plasma membrane
  • apical part of cell
  • endoplasmic reticulum membrane
  • cell-cell junction
  • storage vacuole
  • leading edge membrane
  • Golgi membrane
  • cytosol
General FunctionUbiquitin protein ligase activity
Specific FunctionPlasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP60953
UniProtKB Entry NameCDC42_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017490|Cell division control protein 42 homolog (CDC42)
ATGCAGACAATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTG
ATATCCTACACAACAAACAAATTTCCATCGGAATATGTACCGACTGTTTTTGACAACTAT
GCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGG
CAAGAGGATTATGACAGATTACGACCGCTGAGTTATCCACAAACAGATGTATTTCTAGTC
TGTTTTTCAGTGGTCTCTCCATCTTCATTTGAAAACGTGAAAGAAAAGTGGGTGCCTGAG
ATAACTCACCACTGTCCAAAGACTCCTTTCTTGCTTGTTGGGACTCAAATTGATCTCAGA
GATGACCCCTCTACTATTGAGAAACTTGCCAAGAACAAACAGAAGCCTATCACTCCAGAG
ACTGCTGAAAAGCTGGCCCGTGACCTGAAGGCTGTCAAGTATGTGGAGTGTTCTGCACTT
ACACAGAAAGGCCTAAAGAATGTATTTGACGAAGCAATATTGGCTGCCCTGGAGCCTCCA
GAACCGAAGAAGAGCCGCAGGTGTGTGCTGCTATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:1736
Chromosome Location1
LocusNot Available
References
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