T3DB: ATP-binding cassette sub-family E member 1

Name	ATP-binding cassette sub-family E member 1
Synonyms	2'-5'-oligoadenylate-binding protein HuHP68 Ribonuclease 4 inhibitor RLI RNase L inhibitor RNASEL1 RNASELI RNS4I
Gene Name	ABCE1
Organism	Human
Amino acid sequence	>lcl\|BSEQ0013219\|ATP-binding cassette sub-family E member 1 MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGI CIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTAL KILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAA KGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMF DEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVT MPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEF ELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKS TGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPA DVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPS KNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD
Number of residues	599
Molecular Weight	67313.73
Theoretical pI	Not Available
GO Classification	Functions ATP binding ATPase activity ribonuclease inhibitor activity Processes transmembrane transport response to virus viral process RNA catabolic process negative regulation of catalytic activity Components cytoplasm mitochondrion membrane mitochondrial matrix
General Function	Ribonuclease inhibitor activity
Specific Function	Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Pfam Domain Function	Fer4 (PF00037 ) ABC_tran (PF00005 ) RLI (PF04068 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	P61221
UniProtKB Entry Name	ABCE1_HUMAN
Cellular Location	Cytoplasm
Gene sequence	>lcl\|BSEQ0013220\|ATP-binding cassette sub-family E member 1 (ABCE1) ATGGCAGACAAGTTAACGAGAATTGCTATTGTCAACCATGACAAATGTAAACCTAAGAAA TGTCGACAGGAATGCAAAAAGAGTTGTCCTGTAGTTCGAATGGGAAAATTATGCATAGAG GTTACACCCCAGAGCAAAATAGCATGGATTTCCGAAACTCTTTGTATTGGTTGTGGTATC TGTATTAAGAAATGCCCCTTTGGCGCCTTATCAATTGTCAATCTACCAAGCAACTTGGAA AAAGAAACCACACATCGATATTGTGCCAATGCCTTCAAACTTCACAGGTTGCCTATCCCT CGTCCAGGTGAAGTTTTGGGATTAGTTGGAACTAATGGTATTGGAAAGTCAACTGCTTTA AAAATTTTAGCAGGAAAACAAAAGCCAAACCTTGGAAAGTACGATGATCCTCCTGACTGG CAGGAGATTTTGACTTATTTCCGTGGATCTGAATTACAAAATTACTTTACAAAGATTCTA GAAGATGACCTAAAAGCCATCATCAAACCTCAATATGTAGACCAGATTCCTAAGGCTGCA AAGGGGACAGTGGGATCTATTTTGGACCGAAAAGATGAAACAAAGACACAGGCAATTGTA TGTCAGCAGCTTGATTTAACCCACCTAAAAGAACGAAATGTTGAAGATCTTTCAGGAGGA GAGTTGCAGAGATTTGCTTGTGCTGTCGTTTGCATACAGAAAGCTGATATTTTCATGTTT GATGAGCCTTCTAGTTACCTAGATGTCAAGCAGCGTTTAAAGGCTGCTATTACTATACGA TCTCTAATAAATCCAGATAGATATATCATTGTGGTGGAACATGATCTAAGTGTATTAGAC TATCTCTCCGACTTCATCTGCTGTTTATATGGTGTACCAAGCGCCTATGGAGTTGTCACT ATGCCTTTTAGTGTAAGAGAAGGCATAAACATTTTTTTGGATGGCTATGTTCCAACAGAA AACTTGAGATTCAGAGATGCATCACTTGTTTTTAAAGTGGCTGAGACAGCAAATGAAGAA GAAGTTAAAAAGATGTGTATGTATAAATATCCAGGAATGAAGAAAAAAATGGGAGAATTT GAGCTAGCAATTGTAGCTGGAGAGTTTACAGATTCTGAAATTATGGTGATGCTGGGGGAA AATGGAACGGGTAAAACGACATTTATCAGAATGCTTGCTGGAAGACTTAAACCTGATGAA GGAGGAGAAGTACCAGTTCTAAATGTCAGTTATAAGCCACAGAAAATTAGTCCCAAATCA ACTGGAAGTGTTCGCCAGTTACTACATGAAAAGATAAGAGATGCTTATACTCACCCACAA TTTGTGACCGATGTAATGAAGCCTCTGCAAATTGAAAACATCATTGATCAAGAGGTGCAG ACATTATCTGGTGGTGAACTACAGCGAGTAGCTTTAGCCCTTTGCTTGGGCAAACCTGCT GATGTCTATTTAATTGATGAACCATCTGCATATTTGGATTCTGAGCAAAGACTGATGGCA GCTCGAGTTGTCAAACGTTTCATACTCCATGCAAAAAAGACAGCCTTTGTTGTGGAACAT GACTTCATCATGGCCACCTATCTAGCGGATCGCGTCATCGTTTTTGATGGTGTTCCATCT AAGAACACAGTTGCAAACAGTCCTCAAACCCTTTTGGCTGGCATGAATAAATTTTTGTCT CAGCTTGAAATTACATTCAGAAGAGATCCAAACAACTATAGGCCACGAATAAACAAACTT AATTCAATTAAGGATGTAGAACAAAAGAAGAGTGGAAACTACTTTTTCTTGGATGATTAG
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:69
Chromosome Location	4
Locus	Not Available
References	Bisbal C, Martinand C, Silhol M, Lebleu B, Salehzada T: Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J Biol Chem. 1995 Jun 2;270(22):13308-17. 7539425 Aubry F, Mattei MG, Barque JP, Galibert F: Chromosomal localization and expression pattern of the RNase L inhibitor gene. FEBS Lett. 1996 Feb 26;381(1-2):135-9. 8641422 Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334 Martinand C, Salehzada T, Silhol M, Lebleu B, Bisbal C: RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells. Eur J Biochem. 1998 Jun 1;254(2):248-55. 9660177 Martinand C, Montavon C, Salehzada T, Silhol M, Lebleu B, Bisbal C: RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. J Virol. 1999 Jan;73(1):290-6. 9847332 Le Roy F, Bisbal C, Silhol M, Martinand C, Lebleu B, Salehzada T: The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. J Biol Chem. 2001 Dec 21;276(51):48473-82. Epub 2001 Oct 3. 11585831 Zimmerman C, Klein KC, Kiser PK, Singh AR, Firestein BL, Riba SC, Lingappa JR: Identification of a host protein essential for assembly of immature HIV-1 capsids. Nature. 2002 Jan 3;415(6867):88-92. 11780123 Dooher JE, Lingappa JR: Conservation of a stepwise, energy-sensitive pathway involving HP68 for assembly of primate lentivirus capsids in cells. J Virol. 2004 Feb;78(4):1645-56. 14747530 Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. 21269460 Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. 25944712 Bunger MK, Cargile BJ, Sevinsky JR, Deyanova E, Yates NA, Hendrickson RC, Stephenson JL Jr: Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data. J Proteome Res. 2007 Jun;6(6):2331-40. Epub 2007 May 9. 17488105