Rho-related GTP-binding protein RhoB

NameRho-related GTP-binding protein RhoB
Synonyms
  • ARH6
  • ARHB
  • h6
  • Rho cDNA clone 6
Gene NameRHOB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012483|Rho-related GTP-binding protein RhoB
MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDT
AGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKD
LRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQ
KRYGSQNGCINCCKVL
Number of residues196
Molecular Weight22123.185
Theoretical pI4.85
GO Classification
Functions
  • GDP binding
  • GTP binding
  • GTPase activity
Processes
  • blood coagulation
  • negative regulation of cell migration
  • intracellular protein transport
  • positive regulation of angiogenesis
  • cellular response to hydrogen peroxide
  • small GTPase mediated signal transduction
  • cytokinesis
  • endothelial tube morphogenesis
  • platelet activation
  • negative regulation of cell cycle
  • regulation of cell migration
  • cellular response to ionizing radiation
  • axon guidance
  • positive regulation of apoptotic process
  • endosome to lysosome transport
  • apoptotic process
  • cell adhesion
  • regulation of small GTPase mediated signal transduction
  • Rho protein signal transduction
  • transformed cell apoptotic process
  • angiogenesis
  • positive regulation of endothelial cell migration
Components
  • focal adhesion
  • nucleus
  • plasma membrane
  • early endosome
  • endosome membrane
  • late endosome membrane
  • cytosol
  • extracellular exosome
  • cleavage furrow
General FunctionGtpase activity
Specific FunctionMediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID36032
UniProtKB IDP62745
UniProtKB Entry NameRHOB_HUMAN
Cellular LocationLate endosome membrane
Gene sequence
>lcl|BSEQ0012484|Rho-related GTP-binding protein RhoB (RHOB)
ATGGCGGCCATCCGCAAGAAGCTGGTGGTGGTGGGCGACGGCGCGTGTGGCAAGACGTGC
CTGCTGATCGTGTTCAGTAAGGACGAGTTCCCCGAGGTGTACGTGCCCACCGTCTTCGAG
AACTATGTGGCCGACATTGAGGTGGACGGCAAGCAGGTGGAGCTGGCGCTGTGGGACACG
GCGGGCCAGGAGGACTACGACCGCCTGCGGCCGCTCTCCTACCCGGACACCGACGTCATT
CTCATGTGCTTCTCGGTGGACAGCCCGGACTCGCTGGAGAACATCCCCGAGAAGTGGGTC
CCCGAGGTGAAGCACTTCTGTCCCAATGTGCCCATCATCCTGGTGGCCAACAAAAAAGAC
CTGCGCAGCGACGAGCATGTCCGCACAGAGCTGGCCCGCATGAAGCAGGAACCCGTGCGC
ACGGATGACGGCCGCGCCATGGCCGTGCGCATCCAAGCCTACGACTACCTCGAGTGCTCT
GCCAAGACCAAGGAAGGCGTGCGCGAGGTCTTCGAGACGGCCACGCGCGCCGCGCTGCAG
AAGCGCTACGGCTCCCAGAACGGCTGCATCAACTGCTGCAAGGTGCTATGA
GenBank Gene IDX06820
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:668
Chromosome Location2
Locus2p24
References
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