Histone H2B type 1-C/E/F/G/I

NameHistone H2B type 1-C/E/F/G/I
Synonyms
  • H2B/a
  • H2B/g
  • H2B/h
  • H2B/k
  • H2B/l
  • H2BFA
  • H2BFG
  • H2BFH
  • H2BFK
  • H2BFL
  • Histone H2B.1 A
  • Histone H2B.a
  • Histone H2B.g
  • Histone H2B.h
  • Histone H2B.k
  • Histone H2B.l
Gene NameHIST1H2BC
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019691|Histone H2B type 1-C/E/F/G/I
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Number of residues126
Molecular Weight13906.035
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
Processes
  • nucleosome assembly
  • antibacterial humoral response
  • defense response to Gram-positive bacterium
  • innate immune response in mucosa
  • chromatin organization
Components
  • nuclear nucleosome
  • nucleosome
  • cytoplasm
  • nucleus
  • extracellular space
  • extracellular exosome
  • nucleoplasm
General FunctionDna binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP62807
UniProtKB Entry NameH2B1C_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0019692|Histone H2B type 1-C/E/F/G/I (HIST1H2BC)
ATGCCTGAACCTACCAAGTCTGCTCCTGCCCCAAAGAAGGGCTCCAAGAAGGCGGTGACT
AAGGCTCAGAAGAAGGACGGGAAGAAGCGCAAGCGCAGCCGCAAGGAGAGCTATTCAGTG
TATGTGTACAAGGTGCTGAAGCAGGTCCATCCCGACACCGGCATCTCTTCCAAGGCAATG
GGGATCATGAATTCCTTCGTCAACGACATCTTCGAGCGCATCGCAGGCGAGGCTTCCCGC
CTGGCGCATTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACGGCCGTGCGC
CTGCTGCTTCCGGGGGAGCTGGCCAAGCACGCCGTGTCGGAGGGCACCAAGGCCGTCACC
AAGTACACCAGTTCCAAGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4757
Chromosome Location6
LocusNot Available
References
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