Guanylate kinase

NameGuanylate kinase
Synonyms
  • 2.7.4.8
  • GMP kinase
Gene Namegmk
OrganismMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051155|Guanylate kinase
MSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERIPNLHFSVSATTRAPR
PGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQPVRAAAATGVPVLIEV
DLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETADVIQRRLDTARIELAAQGDF
DKVVVNRRLESACAELVSLLVGTAPGSP
Number of residues208
Molecular Weight22095.065
Theoretical pINot Available
GO Classification
Functions
  • ATP binding
  • adenylate kinase activity
  • magnesium ion binding
  • guanylate kinase activity
  • GDP binding
  • GMP binding
Processes
  • growth
Components
  • cytosol
General FunctionEssential for recycling GMP and indirectly, cGMP.
Specific FunctionAdenylate kinase activity
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP9WKE9
UniProtKB Entry NameKGUA_MYCTU
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0051156|Guanylate kinase (gmk)
GTGAGCGTCGGCGAGGGACCGGACACCAAGCCCACCGCGCGTGGCCAACCGGCGGCAGTG
GGACGTGTGGTGGTGCTGTCCGGTCCTTCCGCGGTCGGCAAATCCACGGTGGTTCGGTGT
CTGCGCGAGCGGATCCCGAATCTGCATTTCAGTGTCTCGGCCACGACGCGGGCGCCACGC
CCGGGCGAGGTCGACGGTGTCGACTACCACTTCATCGACCCCACCCGCTTTCAGCAGCTC
ATCGACCAGGGTGAGTTGCTGGAATGGGCAGAAATCCACGGCGGCCTGCACCGGTCGGGC
ACTTTGGCCCAGCCGGTGCGGGCGGCCGCGGCGACTGGTGTGCCGGTGCTTATCGAGGTT
GACCTGGCCGGGGCCAGGGCGATCAAGAAGACGATGCCCGAGGCTGTCACCGTGTTTCTG
GCGCCACCTAGCTGGCAGGATCTTCAGGCCAGACTGATTGGCCGCGGCACCGAAACAGCT
GACGTTATCCAACGCCGCCTGGACACCGCGCGGATCGAATTGGCAGCGCAGGGCGACTTT
GACAAGGTCGTGGTGAACAGGCGATTAGAGTCTGCGTGTGCGGAATTGGTATCCTTGCTG
GTGGGAACGGCACCGGGCTCCCCGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. 9634230
  2. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. 21969609