Cyclin-dependent kinase 6

NameCyclin-dependent kinase 6
Synonyms
  • 2.7.11.22
  • CDKN6
  • Cell division protein kinase 6
  • Serine/threonine-protein kinase PLSTIRE
Gene NameCDK6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016713|Cyclin-dependent kinase 6
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
Number of residues326
Molecular Weight36938.025
Theoretical pI6.43
GO Classification
Functions
  • cyclin binding
  • ATP binding
  • cyclin-dependent protein serine/threonine kinase activity
Processes
  • negative regulation of cell proliferation
  • T cell differentiation in thymus
  • protein phosphorylation
  • regulation of gene expression
  • positive regulation of fibroblast proliferation
  • negative regulation of cell differentiation
  • regulation of erythrocyte differentiation
  • mitotic cell cycle
  • generation of neurons
  • positive regulation of gene expression
  • negative regulation of osteoblast differentiation
  • G1/S transition of mitotic cell cycle
  • astrocyte development
  • lateral ventricle development
  • Notch signaling pathway
  • response to virus
  • dentate gyrus development
  • gliogenesis
  • cell cycle arrest
  • cell dedifferentiation
  • negative regulation of cell cycle
  • cell division
  • hematopoietic stem cell differentiation
  • regulation of cell motility
  • negative regulation of cellular senescence
  • negative regulation of epithelial cell proliferation
  • type B pancreatic cell development
  • negative regulation of myeloid cell differentiation
  • positive regulation of cell-matrix adhesion
Components
  • ruffle
  • cytoplasm
  • nucleus
  • cyclin-dependent protein kinase holoenzyme complex
  • centrosome
  • cytosol
  • nucleoplasm
General FunctionCyclin-dependent protein serine/threonine kinase activity
Specific FunctionSerine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID36623
UniProtKB IDQ00534
UniProtKB Entry NameCDK6_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016714|Cyclin-dependent kinase 6 (CDK6)
ATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGATCGGG
GAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTG
GCGTTGAAGCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGC
GAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTGGTCAGGTTGTTT
GATGTGTGCACAGTGTCACGAACAGACAGAGAAACCAAACTAACTTTAGTGTTTGAACAT
GTCGATCAAGACTTGACCACTTACTTGGATAAAGTTCCAGAGCCTGGAGTGCCCACTGAA
ACCATAAAGGATATGATGTTTCAGCTTCTCCGAGGTCTGGACTTTCTTCATTCACACCGA
GTAGTGCATCGCGATCTAAAACCACAGAACATTCTGGTGACCAGCAGCGGACAAATAAAA
CTCGCTGACTTCGGCCTTGCCCGCATCTATAGTTTCCAGATGGCTCTAACCTCAGTGGTC
GTCACGCTGTGGTACAGAGCACCCGAAGTCTTGCTCCAGTCCAGCTACGCCACCCCCGTG
GATCTCTGGAGTGTTGGCTGCATATTTGCAGAAATGTTTCGTAGAAAGCCTCTTTTTCGT
GGAAGTTCAGATGTTGATCAACTAGGAAAAATCTTGGACGTGATTGGACTCCCAGGAGAA
GAAGACTGGCCTAGAGATGTTGCCCTTCCCAGGCAGGCTTTTCATTCAAAATCTGCCCAA
CCAATTGAGAAGTTTGTAACAGATATCGATGAACTAGGCAAAGACCTACTTCTGAAGTGT
TTGACATTTAACCCAGCCAAAAGAATATCTGCCTACAGTGCCCTGTCTCACCCATACTTC
CAGGACCTGGAAAGGTGCAAAGAAAACCTGGATTCCCACCTGCCGCCCAGCCAGAACACC
TCGGAGCTGAATACAGCCTGA
GenBank Gene IDX66365
GeneCard IDNot Available
GenAtlas IDCDK6
HGNC IDHGNC:1777
Chromosome Location7
Locus7q21-q22
References
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