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NameFatty acid-binding protein, epidermal
Synonyms
  • E-FABP
  • Epidermal-type fatty acid-binding protein
  • Fatty acid-binding protein 5
  • PA-FABP
  • Psoriasis-associated fatty acid-binding protein homolog
Gene NameFABP5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0011430|Fatty acid-binding protein, epidermal
MATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTL
KTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVEC
VMNNVTCTRIYEKVE
Number of residues135
Molecular Weight15164.36
Theoretical pI7.05
GO Classification
Functions
  • transporter activity
  • lipid binding
  • fatty acid binding
Processes
  • phosphatidylcholine biosynthetic process
  • glucose transport
  • triglyceride catabolic process
  • small molecule metabolic process
  • glucose metabolic process
  • lipid metabolic process
  • epidermis development
Components
  • cytoplasm
  • cytosol
  • extracellular exosome
  • nucleoplasm
General FunctionTransporter activity
Specific FunctionHigh specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID182354
UniProtKB IDQ01469
UniProtKB Entry NameFABP5_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0011431|Fatty acid-binding protein, epidermal (FABP5)
ATGGCCACAGTTCAGCAGCTGGAAGGAAGATGGCGCCTGGTGGACAGCAAAGGCTTTGAT
GAATACATGAAGGAGCTAGGAGTGGGAATAGCTTTGCGAAAAATGGGCGCAATGGCCAAG
CCAGATTGTATCATCACTTGTGATGGTAAAAACCTCACCATAAAAACTGAGAGCACTTTG
AAAACAACACAGTTTTCTTGTACCCTGGGAGAGAAGTTTGAAGAAACCACAGCTGATGGC
AGAAAAACTCAGACTGTCTGCAACTTTACAGATGGTGCATTGGTTCAGCATCAGGAGTGG
GATGGGAAGGAAAGCACAATAACAAGAAAATTGAAAGATGGGAAATTAGTGGTGGAGTGT
GTCATGAACAATGTCACCTGTACTCGGATCTATGAAAAAGTAGAATAA
GenBank Gene IDM94856
GeneCard IDNot Available
GenAtlas IDFABP5
HGNC IDHGNC:3560
Chromosome Location8
Locus8q21.13
References
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