ATP-dependent 6-phosphofructokinase, platelet type

NameATP-dependent 6-phosphofructokinase, platelet type
Synonyms
  • 2.7.1.11
  • 6-phosphofructokinase type C
  • ATP-PFK
  • PFK-C
  • PFKF
  • Phosphofructo-1-kinase isozyme C
  • Phosphohexokinase
Gene NamePFKP
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008944|ATP-dependent 6-phosphofructokinase, platelet type
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFI
YEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGIT
NLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG
TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLP
ESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDT
RVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMEC
VQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGA
PAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTK
RVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVS
NNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGA
DAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKG
VFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVL
GISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQ
PWSV
Number of residues784
Molecular Weight85595.405
Theoretical pINot Available
GO Classification
Functions
  • protein complex binding
  • ATP binding
  • metal ion binding
  • 6-phosphofructokinase activity
Processes
  • canonical glycolysis
  • mitophagy in response to mitochondrial depolarization
  • fructose 6-phosphate metabolic process
  • small molecule metabolic process
  • carbohydrate metabolic process
  • glucose metabolic process
Components
  • membrane
  • nucleus
  • cytosol
  • extracellular exosome
General FunctionProtein complex binding
Specific FunctionCatalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ01813
UniProtKB Entry NamePFKAP_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013522|ATP-dependent 6-phosphofructokinase, platelet type (PFKP)
ATGTGCGGGTATGAACGCTGCCGTCCGTGCCGTGGTGCGCATGGGTATCTACGTGGGGGC
CAAGGTGTACTTCATCTACGAGGGCTACCAGGGCATGGTGGACGGAGGCTCAAACATCGC
AGAGGCCGACTGGGAGAGTGTCTCCAGCATCCTGCAAGTGGTGCTGTAAGGGGTGACTGG
AGGGAGAAGCCTGGCTGCTGGTCACACCGCTTCCCTTGTCCTGGCCGGCATGCTCTGGTG
GGCGGGACGATCATTGGCAGTGCGCGGTGCCAGGCCTTCCGCACGCGGGAAGGCCGCCTG
AAGGCTGCTTGCAACCTGCTGCAGCGCGGCATCACCAACCTGTGTGTGATCGGCGGGGAC
GGGAGCCTCACCGGGGCCAACCTCTTCCGGAAGGAGTGGAGTGGGCTGCTGGAGGAGCTG
GCCAGGAACGGCCAGATCGATAAGGAGGCCGTGCAGAAGTACGCCTACCTCAACGTGGTG
GGCATGGTGGGCTCCATCGACAATGATTTCTGCGGCACCGACATGACCATCGGCACGGAC
TCCGCCCTGCACAGGATCATCGAGGTCGTCGACGCCATCATGACCACGGCCCAGAGCCAC
CAGAGGACCTTCGTTCTGGAGGTGATGGGACGACACTGTGGGTACCTGGCCCTGGTGAGT
GCCTTGGCCTGCGGTGCGGACTGGGTGTTCCTTCCAGAATCTCCACCAGAGGAAGGCTGG
GAGGAGCAGATGTGTGTCAAACTCTCGGAGAACCGTGCCCGGAAAAAAAGGCTGAATATT
ATTATTGTGGCTGAAGGAGCAATTGATACCCAAAATAAACCCATCACCTCTGAGAAAATC
AAAGAGCTTGTCGTCACGCAGCTGGGCTATGACACACGTGTGACCATCCTCGGGCACGTG
CAGAGAGGAGGGACCCCTTCGGCATTCGACAGGATCTTGGCCAGCCGCATGGGAGTGGAG
GCAGTCATCGCCTTGCTAGAGGCCACCCCGGACACCCCAGCTTGCGTCGTGTCACTGAAC
GGGAACCACGCCGTGCGCCTGCCGCTGATGGAGTGCGTGCAGATGACTCAGGATGTGCAG
AAGGCGATGGACGAGAGGAGATTTCAAGATGCGGTTCGACTCCGAGGGAGGAGCTTTGCG
GGCAACCTGAACACCTACAAGCGACTTGCCATCAAGCTGCCGGATGATCAGATCCCAAAG
ACCAATTGCAACGTAGCTGTCATCAACGTGGGGGCACCCGCGGCTGGGATGAACGCAGCC
GTACGCTCAGCTGTGCGCGTGGGCATTGCCGACGGCCACAGGATGCTCGCCATCTATGAT
GGCTTTGACGGCTTCGCCAAGGGCCAGATCAAAGAAATCGGCTGGACAGATGTCGGGGGC
TGGACCGGCCAAGGAGGCTCCATTCTTGGGACAAAACGCGTTCTCCCGGGGAAGTACTTG
GAAGAGATCGCCACACAGATGCGCACGCACAGCATCAACGCGCTGCTGATCATCGGTGGA
TTCGAGGCCTACCTGGGACTCCTGGAGCTGTCAGCCGCCCGGGAGAAGCACGAGGAGTTC
TGTGTCCCCATGGTCATGGTTCCCGCTACTGTGTCCAACAATGTGCCGGGTTCCGATTTC
AGCATCGGGGCAGACACCGCCCTGAACACTATCACCGACACCTGCGACCGCATCAAGCAG
TCCGCCAGCGGAACCAAGCGGCGCGTGTTCATCATCGAGACCATGGGCGGCTACTGTGGC
TACCTGGCCAACATGGGGGGGCTCGCGGCCGGAGCTGATGCCGCATACATTTTCGAAGAG
CCCTTCGACATCAGGGATCTGCAGTCCAACGTGGAGCACCTGACGGAGAAAATGAAGACC
ACCATCCAGAGAGGCCTTGTGCTCAGAAATGAGAGCTGCAGTGAAAACTACACCACCGAC
TTCATTTACCAGCTGTATTCAGAAGAGGGCAAAGGCGTGTTTGACTGCAGGAAGAACGTG
CTGGGTCACATGCAGCAGGGTGGGGCACCCTCTCCATTTGATAGAAACTTTGGAACCAAA
ATCTCTGCCAGAGCTATGGAGTGGATCACTGCAAAACTCAAGGAGGCCCGGGGCAGAGGA
AAAAAATTTACCACCGATGATTCCATTTGTGTGCTGGGAATAAGCAAAAGAAACGTTATT
TTTCAACCTGTGGCAGAGCTGAAGAAGCAAACGGATTTTGAGCACAGGATTCCCAAAGAA
CAGTGGTGGCTCAAGCTACGGCCCCTCATGAAAATCCTGGCCAAGTACAAGGCCAGCTAT
GACGTGTCGGACTCAGGCCAGCTGGAACATGTGCAGCCCTGGAGTGTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:8878
Chromosome Location10
LocusNot Available
References
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