Peptidyl-prolyl cis-trans isomerase FKBP4

NamePeptidyl-prolyl cis-trans isomerase FKBP4
Synonyms
  • 5.2.1.8
  • 51 kDa FK506-binding protein
  • 52 kDa FK506-binding protein
  • 52 kDa FKBP
  • 59 kDa immunophilin
  • FK506-binding protein 4
  • FKBP-4
  • FKBP-52
  • FKBP51
  • FKBP52
  • FKBP59
  • HBI
  • HSP-binding immunophilin
  • Immunophilin FKBP52
  • p59
  • PPIase FKBP4
  • Rotamase
Gene NameFKBP4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020619|Peptidyl-prolyl cis-trans isomerase FKBP4
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGW
LLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPP
KIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKD
KLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPN
AELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWL
EYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRG
EAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAE
EENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
Number of residues459
Molecular Weight51804.17
Theoretical pI5.11
GO Classification
Functions
  • GTP binding
  • FK506 binding
  • peptidyl-prolyl cis-trans isomerase activity
  • heat shock protein binding
  • poly(A) RNA binding
  • protein binding, bridging
  • ATP binding
Processes
  • chaperone-mediated protein folding
  • protein folding
  • cellular response to heat
  • negative regulation of microtubule polymerization or depolymerization
  • regulation of cellular response to heat
  • androgen receptor signaling pathway
  • copper ion transport
  • negative regulation of neuron projection development
  • protein complex localization
  • negative regulation of microtubule polymerization
  • male sex differentiation
  • steroid hormone receptor complex assembly
  • embryo implantation
  • prostate gland development
Components
  • microtubule
  • endoplasmic reticulum membrane
  • axonal growth cone
  • cytosol
  • extracellular exosome
  • nucleoplasm
  • perinuclear region of cytoplasm
  • neuronal cell body
  • cytoplasm
  • mitochondrion
General FunctionProtein binding, bridging
Specific FunctionImmunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ02790
UniProtKB Entry NameFKBP4_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020620|Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)
ATGACAGCCGAGGAGATGAAGGCGACCGAGAGCGGGGCGCAGTCGGCGCCGCTGCCCATG
GAGGGAGTGGACATCAGCCCCAAACAGGACGAAGGCGTGCTGAAGGTCATCAAGAGAGAG
GGCACAGGTACAGAGATGCCCATGATTGGGGACCGAGTCTTTGTCCACTACACTGGCTGG
CTATTAGATGGCACAAAGTTTGACTCCAGTCTGGATCGCAAGGACAAATTCTCCTTTGAC
CTGGGAAAAGGGGAGGTCATCAAGGCTTGGGACATTGCCATAGCCACCATGAAGGTGGGG
GAGGTGTGCCACATCACCTGCAAACCAGAATATGCCTACGGTTCAGCAGGCAGTCCTCCA
AAGATTCCCCCCAATGCCACGCTTGTATTTGAGGTGGAGTTGTTTGAGTTTAAGGGAGAA
GATCTGACGGAAGAGGAAGATGGCGGAATCATTCGCAGAATACAGACTCGCGGTGAAGGC
TATGCTAAGCCCAATGAGGGTGCTATCGTGGAGGTTGCACTGGAAGGGTACTACAAGGAC
AAGCTCTTTGACCAGCGGGAGCTCCGCTTTGAGATTGGCGAGGGGGAGAACCTGGATCTG
CCTTATGGTCTGGAGAGGGCCATTCAGCGCATGGAGAAAGGAGAACATTCCATCGTGTAC
CTCAAGCCCAGCTATGCTTTTGGCAGTGTTGGGAAGGAAAAGTTCCAAATCCCACCAAAT
GCTGAGCTGAAATATGAATTACACCTCAAGAGTTTTGAAAAGGCCAAGGAGTCTTGGGAG
ATGAATTCAGAAGAGAAGCTGGAACAGAGCACCATAGTGAAAGAGCGGGGCACTGTGTAC
TTCAAGGAAGGTAAATACAAGCAAGCTTTACTACAGTATAAGAAGATCGTGTCTTGGCTG
GAATATGAGTCTAGTTTTTCCAATGAGGAAGCACAGAAAGCACAGGCCCTTCGACTGGCC
TCTCACCTCAACCTGGCCATGTGTCATCTGAAACTACAGGCCTTCTCTGCTGCCATTGAA
AGCTGTAACAAGGCCCTAGAACTGGACAGCAACAACGAGAAGGGCCTCTTCCGCCGGGGA
GAGGCCCACCTGGCCGTGAATGACTTTGAACTGGCACGGGCTGATTTCCAGAAGGTCCTG
CAGCTCTACCCCAACAACAAAGCCGCCAAGACCCAGCTGGCTGTGTGCCAGCAGCGGATC
CGAAGGCAGCTTGCCCGGGAGAAGAAGCTCTATGCCAATATGTTTGAGAGGCTGGCTGAG
GAGGAGAACAAGGCCAAGGCAGAGGCTTCCTCAGGAGACCATCCCACTGACACAGAGATG
AAGGAGGAGCAGAAGAGCAACACGGCAGGGAGCCAGTCTCAGGTGGAGACAGAAGCATAG
GenBank Gene IDM88279
GeneCard IDNot Available
GenAtlas IDFKBP4
HGNC IDHGNC:3720
Chromosome Location12
Locus12p13.33
References
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