NameSialidase
Synonyms
  • 3.2.1.18
  • Neuraminidase
Gene NamenedA
OrganismMicromonospora viridifaciens
Amino acid sequence
>lcl|BSEQ0016618|Sialidase
MTANPYLRRLPRRRAVSFLLAPALAAATVAGASPAQAIAGAPVPPGGEPLYTEQDLAVNG
REGFPNYRIPALTVTPDGDLLASYDGRPTGIDAPGPNSILQRRSTDGGRTWGEQQVVSAG
QTTAPIKGFSDPSYLVDRETGTIFNFHVYSQRQGFAGSRPGTDPADPNVLHANVATSTDG
GLTWSHRTITADITPDPGWRSRFAASGEGIQLRYGPHAGRLIQQYTIINAAGAFQAVSVY
SDDHGRTWRAGEAVGVGMDENKTVELSDGRVLLNSRDSARSGYRKVAVSTDGGHSYGPVT
IDRDLPDPTNNASIIRAFPDAPAGSARAKVLLFSNAASQTSRSQGTIRMSCDDGQTWPVS
KVFQPGSMSYSTLTALPDGTYGLLYEPGTGIRYANFNLAWLGGICAPFTIPDVALEPGQQ
VTVPVAVTNQSGIAVPKPSLQLDASPDWQVQGSVEPLMPGRQAKGQVTITVPAGTTPGRY
RVGATLRTSAGNASTTFTVTVGLLDQARMSIADVDSEETAREDGRASNVIDGNPSTFWHT
EWSRADAPGYPHRISLDLGGTHTISGLQYTRRQNSANEQVADYEIYTSLNGTTWDGPVAS
GRFTTSLAPQRAVFPARDARYIRLVALSEQTGHKYAAVAELEVEGQR
Number of residues647
Molecular Weight68829.78
Theoretical pI6.52
GO Classification
Functions
  • exo-alpha-(2->8)-sialidase activity
  • exo-alpha-(2->3)-sialidase activity
  • exo-alpha-(2->6)-sialidase activity
Components
  • extracellular region
General FunctionExo-alpha-(2->8)-sialidase activity
Specific FunctionTo release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID216784
UniProtKB IDQ02834
UniProtKB Entry NameNANH_MICVI
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0003854|1944 bp
ATGACTGCGAATCCGTACCTCCGCCGCCTGCCCCGGCGCCGAGCCGTCAGCTTCCTGCTC
GCACCAGCGCTGGCGGCCGCCACGGTCGCCGGCGCGTCCCCCGCACAGGCCATCGCCGGG
GCACCCGTCCCGCCCGGCGGCGAGCCGCTCTACACGGAGCAGGACCTCGCCGTGAACGGC
AGGGAGGGCTTTCCGAACTACCGCATCCCAGCGCTGACCGTCACGCCCGACGGGGACCTG
CTGGCCTCGTACGACGGCCGCCCGACCGGTATCGACGCGCCCGGCCCCAACTCCATCCTC
CAACGCCGCAGCACCGACGGCGGCCGGACGTGGGGCGAGCAACAGGTCGTCAGCGCCGGC
CAGACCACCGCGCCGATCAAGGGGTTCTCCGACCCCAGCTACCTTGTCGACCGGGAAACC
GGGACCATCTTCAACTTCCACGTCTACTCCCAGCGGCAGGGCTTCGCCGGCAGCCGGCCC
GGCACCGACCCGGCAGACCCCAACGTGCTCCACGCCAACGTCGCGACCTCGACCGACGGC
GGTCTGACCTGGTCGCACCGGACCATCACGGCCGACATCACCCCGGATCCGGGCTGGCGC
AGCCGCTTCGCCGCCTCCGGCGAAGGCATCCAGCTCCGCTATGGACCCCACGCCGGTCGA
CTCATCCAGCAGTACACGATCATCAACGCTGCCGGCGCCTTCCAGGCGGTGAGCGTGTAC
AGCGACGACCACGGAAGGACCTGGCGCGCCGGCGAAGCCGTCGGGGTCGGCATGGACGAG
AACAAGACCGTGGAACTCTCCGATGGCCGGGTCCTGCTCAACAGCCGCGACTCGGCCCGC
AGCGGATACCGTAAGGTGGCCGTCTCCACTGACGGCGGCCACAGCTACGGCCCGGTGACC
ATCGACCGCGACCTCCCCGACCCGACGAACAACGCATCGATCATCCGGGCCTTCCCTGAC
GCCCCGGCCGGCTCCGCGCGGGCCAAGGTCCTGCTCTTCTCCAACGCCGCCAGCCAGACC
TCGCGCAGTCAGGGCACCATCCGGATGTCCTGCGACGATGGCCAGACCTGGCCGGTTTCG
AAGGTCTTCCAGCCCGGCTCGATGTCGTACTCCACCCTGACCGCACTGCCCGACGGCACC
TACGGGCTGCTGTACGAGCCGGGCACCGGCATCAGATACGCCAACTTCAACCTCGCCTGG
CTGGGCGGCATCTGCGCGCCCTTCACGATTCCGGATGTGGCGCTCGAGCCGGGCCAGCAG
GTCACTGTTCCGGTGGCCGTCACGAACCAGTCCGGTATCGCGGTACCGAAGCCGAGCCTT
CAGCTCGACGCATCGCCGGACTGGCAGGTTCAGGGTTCCGTCGAGCCCCTCATGCCCGGA
CGGCAGGCCAAGGGCCAGGTGACCATCACGGTTCCCGCCGGCACCACCCCCGGTCGCTAC
CGGGTCGGTGCGACGCTGCGCACCTCCGCGGGTAACGCGTCGACGACCTTCACGGTCACG
GTTGGACTGCTCGACCAGGCCCGGATGAGCATCGCGGACGTCGACAGCGAGGAGACCGCC
CGCGAAGACGGGCGGGCGAGCAACGTGATCGACGGCAACCCCTCGACGTTCTGGCACACC
GAATGGTCGCGTGCCGATGCTCCTGGCTACCCGCACCGCATCAGCCTCGACCTCGGTGGC
ACGCACACGATCAGCGGCCTCCAGTACACCCGACGGCAGAACAGCGCCAACGAGCAGGTC
GCGGACTACGAGATCTACACCAGCCTGAACGGCACGACCTGGGATGGCCCGGTTGCCAGC
GGGCGCTTCACCACGTCCCTCGCGCCGCAGCGCGCGGTCTTCCCGGCGCGGGACGCCAGG
TACATCCGGTTGGTGGCCCTCAGCGAGCAGACCGGGCACAAGTACGCCGCGGTCGCTGAG
CTGGAGGTGGAAGGCCAGCGCTGA
GenBank Gene IDD01045
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Sakurada K, Ohta T, Hasegawa M: Cloning, expression, and characterization of the Micromonospora viridifaciens neuraminidase gene in Streptomyces lividans. J Bacteriol. 1992 Nov;174(21):6896-903. 1400240
  2. Gaskell A, Crennell S, Taylor G: The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll. Structure. 1995 Nov 15;3(11):1197-205. 8591030