NameGag-Pro-Pol polyprotein
Synonyms
  • 3.4.23.-
  • RT-beta
Gene Namegag-pro-pol
OrganismRSV-SRA
Amino acid sequence
>lcl|BSEQ0037153|Gag-Pro-Pol polyprotein
MEAVIKVISSACKTYCGKISPSKKEIGAMLSLLQKEGLLMSPSDLYSPGSWDPITAALSQ
RAMVLGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGGGRVSPPGPECIEKPATER
RIDKGEEVGETTAQRDAKMAPEKMATPKTVGTSCYQCGTATGCNCATASAPPPPYVGSGL
YPSLAGVGEQQGQGGDTPWGAEQPRAEPGHAGLAPGPALTDWARIREELASTGPPVVAMP
VVIKTEGPAWTPLEPKLITRLADTVRTKGLRSPITMAEVEALMSSPLLPHDVTNLMRVIL
GPAPYALWMDAWGVQLQTVIAAATRDPRHPANGQGRGERTNLDRLKGLADGMVGNPQGQA
ALLRPGELVAITASALQAFREVARLAEPAGPWADITQGPSESFVDFANRLIKAVEGSDLP
PSARAPVIIDCFRQKSQPDIQQLIRAAPSTLTTPGEIIKYVLDRQKIAPLTDQGIAAAMS
SAIQPLVMAVVNRERDGQTGSGGRARGLCYTCGSPGHYQAQCPKKRKSGNSRERCQLCDG
MGHNAKQCRRRDGNQGQRPGKGLSSGSWPVSEQPAVSLAMTMEHKDRPLVRVILTNTGSH
PVKQRSVYITALLDSGADITIISEEDWPTDWPVMEAANPQIHGIGGGIPMRKSRDMIEVG
VINRDGSLERPLLLFPAVAMVRGSILGRDCLQGLGLRLTNLIGRATVLTVALHLAIPLKW
KPDHTPVWIDQWPLPEGKLVALTQLVEKELQLGHIEPSLSCWNTPVFVIRKASGSYRLLH
DLRAVNAKLVPFGAVQQGAPVLSALPRGWPLMVLDLKDCFFSIPLAEQDREAFAFTLPSV
NNQAPARRFQWKVLPQGMTCSPTICQLVVGQVLEPLRLKHPSLRMLHYMDDLLLAASSHD
GLEAAGEEVISTLERAGFTISPDKIQREPGVQYLGYKLGSTYVAPVGLVAEPRIATLWDV
QKLVGSLQWLRPALGIPPRLMGPFYEQLRGSDPNEAREWNLDMKMAWREIVQLSTTAALE
RWDPALPLEGAVARCEQGAIGVLGQGLSTHPRPCLWLFSTQPTKAFTAWLEVLTLLITKL
RASAVRTFGKEVDILLLPACFREDLPLPEGILLALRGFAGKIRSSDTPSIFDIARPLHVS
LKVRVTDHPVPGPTAFTDASSSTHKGVVVWREGPRWEIKEIADLGASVQQLEARAVAMAL
LLWPTTPTNVVTDSAFVAKMLLKMGQEGVPSTAAAFILEDALSQRSAMAAVLHVRSHSEV
PGFFTEGNDVADSQATFQAYPLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHC
NSAPALEAGVNPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA
AQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNSQGQAMVERAN
RLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFERGENTKTPIQKHWRPTVLTE
GPPVKIRIETGEWEKGWNVLVWGRGYAAVKNRDTDKVIWVPSRKVKPDVTQKDEVTKKDE
ASPLFAGISDWIPWEDEQEGLQGETASNKQERPGEDTLAANES
Number of residues1603
Molecular Weight173931.55
Theoretical pI8.1
GO Classification
Functions
  • RNA-directed DNA polymerase activity
  • RNA-DNA hybrid ribonuclease activity
  • zinc ion binding
  • RNA binding
  • structural molecule activity
  • DNA binding
  • DNA-directed DNA polymerase activity
  • aspartic-type endopeptidase activity
Processes
  • DNA integration
  • viral entry into host cell
  • establishment of integrated proviral latency
  • DNA recombination
Components
  • viral capsid
General FunctionZinc ion binding
Specific FunctionCapsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID210273
UniProtKB IDQ04095
UniProtKB Entry NamePOL_RSVSA
Cellular LocationVirion
Gene sequence
>lcl|BSEQ0003776|2688 bp
ACTGTTGCGCTACATCTGGCTATTCCGCTCAAATGGAAGCCAGACCACACGCCTGTGTGG
ATTGACCAGTGGCCCCTTCCTGAAGGTAAACTTGTAGCGCTAACGCAATTAGTGGAAAAA
GAATTACAGTTAGGACATATAGAACCTTCACTTAGTTGTTGGAACACACCTGTCTTTGTG
ATCCGGAAGGCTTCCGGGTCTTATCGCTTATTGCATGACTTGCGCGCTGTTAACGCCAAG
CTTGTTCCTTTTGGGGCCGTCCAACAGGGGGCGCCAGTTCTCTCCGCGCTCCCGCGTGGC
TGGCCCCTGATGGTCCTAGACCTCAAGGATTGCTTCTTTTCTATTCCTCTTGCGGAACAA
GATCGCGAAGCTTTTGCATTTACGCTCCCCTCTGTGAATAACCAGGCCCCCGCTCGAAGA
TTCCAATGGAAGGTCTTGCCCCAAGGGATGACCTGTTCTCCCACTATCTGTCAGTTGGTG
GTGGGTCAGGTACTTGAGCCCTTGCGACTCAAGCACCCATCTCTGCGCATGTTGCATTAT
ATGGATGATCTTTTGCTAGCCGCCTCAAGTCATGATGGGTTGGAAGCGGCAGGGGAGGAG
GTTATCAGTACATTGGAAAGAGCCGGGTTCACCATTTCGCCTGATAAGATCCAGAGGGAA
CCCGGAGTACAATATCTTGGGTACAAGTTAGGCAGTACGTATGTAGCACCCGTAGGCCTG
GTAGCAGAACCCAGGATAGCCACCTTGTGGGATGTTCAAAAGCTGGTGGGGTCACTTCAG
TGGCTTCGCCCAGCGTTAGGAATCCCGCCACGACTGATGGGCCCCTTCTATGAGCAGTTA
CGAGGGTCAGATCCTAACGAGGCGAGGGAATGGAATCTAGACATGAAAATGGCCTGGAGA
GAGATCGTACAGCTTAGCACCACTGCTGCCTTGGAACGATGGGACCCTGCCCTGCCTTTG
GAGGGAGCGGTCGCTAGGTGTGAACAGGGGGCAATAGGGGTCCTGGGACAGGGACTGTCC
ACACACCCAAGGCCATGTTTGTGGTTATTCTCCACCCAACCCACCAAGGCGTTTACTGCT
TGGTTAGAAGTGCTCACCCTTTTGATTACTAAGCTACGCGCTTCGGCAGTGCGAACCTTT
GGCAAGGAGGTTGATATCCTCCTGTTGCCTGCATGCTTTCGGGAGGACCTTCCGCTCCCG
GAGGGGATCCTGTTAGCCCTTAGGGGGTTTGCAGGAAAAATCAGGAGTAGTGACACGCCA
TCTATTTTTGACATTGCGCGTCCACTGCATGTTTCTCTGAAAGTGAGGGTCACCGACCAC
CCTGTACCGGGACCCACTGCCTTTACCGACGCCTCCTCAAGCACCCATAAAGGGGTGGTA
GTCTGGAGGGAGGGCCCAAGGTGGGAGATAAAAGAAATAGCTGATTTGGGGGCAAGTGTA
CAACAACTGGAAGCACGCGCTGTGGCCATGGCACTTCTGCTGTGGCCGACAACGCCCACT
AATGTAGTGACTGACTCCGCGTTTGTCGCGAAAATGTTACTCAAGATGGGACAGGAGGGA
GTCCCGTCTACAGCGGCGGCTTTTATTTTAGAGGATGCGTTAAGCCAAAGGTCAGCCATG
GCCGCCGTTCTCCACGTGCGGAGTCATTCTGAAGTGCCAGGGTTTTTCACAGAAGGAAAT
GACGTGGCAGATAGCCAAGCCACCTTTCAAGCGTATCCCTTGAGAGAGGCTAAAGATCTT
CATACTGCTCTCCATATTGGACCCCGCGCGCTATCCAAAGCGTGTAATATATCTATGCAG
CAGGCTAGGGAGGTTGTTCAGACCTGCCCGCATTGTAATTCAGCCCCTGCGTTGGAGGCC
GGGGTAAACCCTAGGGGTTTGGGACCCCTACAGATATGGCAGACAGACTTTACGCTTGAG
CCTAGAATGGCCCCCCGTTCCTGGCTCGCTGTTACTGTGGATACCGCCTCATCGGCGATA
GTCGTAACTCAGCATGGCCGTGTCACATCGGTTGCTGCACAACATCATTGGGCCACGGCT
ATCGCCGTTTTGGGAAGACCAAAGGCCATAAAAACAGATAATGGGTCCTGTTTCACGTCT
AAATCCACGCGAGAGTGGCTCGCGAGATGGGGGATAGCACACACCACCGGGATTCCGGGT
AATTCCCAGGGTCAAGCTATGGTAGAGCGGGCCAACCGGCTCCTGAAAGATAAGATCCGT
GTGCTTGCGGAGGGGGACGGCTTTATGAAAAGAATCCCCACCAGCAAACAGGGGGAACTA
CTAGCCAAGGCAATGTATGCCCTCAATCACTTTGAGCGCGGTGAAAACACAAAAACACCG
ATTCAAAAACACTGGAGACCTACCGTTCTTACAGAAGGACCCCCGGTTAAAATACGAATA
GAGACAGGGGAGTGGGAAAAAGGATGGAATGTGCTGGTCTGGGGACGAGGTTATGCAGCT
GTGAAAAACAGGGACACTGATAAGGTTATTTGGGTACCCTCTCGGAAAGTTAAACCGGAT
GTCACCCAAAAGGATGAGGTGACTAAGAAAGATGAGGCGAGCCCTCTTTTTGCAGGCATT
TCTGACTGGATACCCTGGGAAGACGAGCAAGAAGGACTCCAAGGAGAAACCGCTAGCAAC
AAGCAAGAAAGACCCGGAGAAGACACCCTTGCTGCCAACGAGAGTTAA
GenBank Gene IDM37980
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Bieth E, Darlix JL: Complete nucleotide sequence of a highly infectious avian leukosis virus. Nucleic Acids Res. 1992 Jan 25;20(2):367. 1311072
  2. Katzman M, Katz RA, Skalka AM, Leis J: The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration. J Virol. 1989 Dec;63(12):5319-27. 2555556
  3. Arad G, Bar-Meir R, Kotler M: Ribosomal frameshifting at the Gag-Pol junction in avian leukemia sarcoma virus forms a novel cleavage site. FEBS Lett. 1995 May 1;364(1):1-4. 7750533