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NameProtein kinase C delta type
  • nPKC-delta
  • Tyrosine-protein kinase PRKCD
Gene NamePRKCD
Amino acid sequence
>lcl|BSEQ0037204|Protein kinase C delta type
Number of residues676
Molecular Weight77504.445
Theoretical pI7.81
GO Classification
  • metal ion binding
  • non-membrane spanning protein tyrosine kinase activity
  • calcium-independent protein kinase C activity
  • insulin receptor substrate binding
  • enzyme binding
  • protein kinase C activity
  • ATP binding
  • protein kinase activity
  • kinase binding
  • protein serine/threonine kinase activity
  • enzyme activator activity
  • fibroblast growth factor receptor signaling pathway
  • cellular senescence
  • positive regulation of apoptotic signaling pathway
  • positive regulation of sphingomyelin catabolic process
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of ceramide biosynthetic process
  • positive regulation of protein dephosphorylation
  • termination of signal transduction
  • protein phosphorylation
  • cell cycle
  • regulation of mRNA stability
  • stimulatory C-type lectin receptor signaling pathway
  • platelet activation
  • interferon-gamma-mediated signaling pathway
  • vascular endothelial growth factor receptor signaling pathway
  • cellular response to hydroperoxide
  • negative regulation of MAP kinase activity
  • defense response to bacterium
  • interleukin-12 production
  • positive regulation of superoxide anion generation
  • signal transduction
  • immunoglobulin mediated immune response
  • intrinsic apoptotic signaling pathway in response to oxidative stress
  • gene expression
  • negative regulation of insulin receptor signaling pathway
  • cell chemotaxis
  • negative regulation of actin filament polymerization
  • neutrophil activation
  • B cell proliferation
  • negative regulation of filopodium assembly
  • negative regulation of inflammatory response
  • negative regulation of peptidyl-tyrosine phosphorylation
  • cellular component disassembly involved in execution phase of apoptosis
  • blood coagulation
  • cytokine-mediated signaling pathway
  • negative regulation of platelet aggregation
  • negative regulation of protein binding
  • positive regulation of endodeoxyribonuclease activity
  • epidermal growth factor receptor signaling pathway
  • protein stabilization
  • activation of phospholipase C activity
  • positive regulation of glucosylceramide catabolic process
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • negative regulation of glial cell apoptotic process
  • programmed cell death
  • regulation of receptor activity
  • positive regulation of phospholipid scramblase activity
  • innate immune response
  • regulation of actin cytoskeleton organization
  • histone phosphorylation
  • peptidyl-threonine phosphorylation
  • positive regulation of protein import into nucleus
  • apoptotic process
  • interleukin-10 production
  • positive regulation of response to DNA damage stimulus
  • cytoplasm
  • mitochondrion
  • cytosol
  • extracellular exosome
  • nucleoplasm
  • perinuclear region of cytoplasm
  • nucleus
  • nuclear matrix
  • endoplasmic reticulum
  • plasma membrane
  • cell-cell junction
General FunctionProtein serine/threonine kinase activity
Specific FunctionCalcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ05655
UniProtKB Entry NameKPCD_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0011729|Protein kinase C delta type (PRKCD)
GenBank Gene IDL07860
GeneCard IDNot Available
Chromosome Location3
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