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NameTyrosine-protein phosphatase non-receptor type 11
Synonyms
  • 3.1.3.48
  • Protein-tyrosine phosphatase 1D
  • Protein-tyrosine phosphatase 2C
  • PTP-1D
  • PTP-2C
  • PTP2C
  • SH-PTP2
  • SH-PTP3
  • SHP-2
  • Shp2
  • SHPTP2
Gene NamePTPN11
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002133|Tyrosine-protein phosphatase non-receptor type 11
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVW
QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILI
DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSK
RKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
Number of residues597
Molecular Weight68436.0
Theoretical pI7.31
GO Classification
Functions
  • phosphoprotein phosphatase activity
  • protein tyrosine phosphatase activity
  • insulin receptor binding
  • non-membrane spanning protein tyrosine phosphatase activity
  • SH3/SH2 adaptor activity
Processes
  • positive regulation of mitotic cell cycle
  • microvillus organization
  • platelet-derived growth factor receptor signaling pathway
  • positive regulation of glucose import in response to insulin stimulus
  • negative regulation of cell adhesion mediated by integrin
  • negative regulation of cortisol secretion
  • Fc-epsilon receptor signaling pathway
  • peptidyl-tyrosine dephosphorylation
  • activation of MAPK activity
  • negative regulation of growth hormone secretion
  • face morphogenesis
  • regulation of protein complex assembly
  • hormone-mediated signaling pathway
  • leukocyte migration
  • multicellular organismal reproductive process
  • T cell costimulation
  • multicellular organism growth
  • DNA damage checkpoint
  • blood coagulation
  • hormone metabolic process
  • fibroblast growth factor receptor signaling pathway
  • platelet formation
  • megakaryocyte development
  • negative regulation of insulin secretion
  • heart development
  • atrioventricular canal development
  • regulation of type I interferon-mediated signaling pathway
  • insulin receptor signaling pathway
  • positive regulation of hormone secretion
  • type I interferon signaling pathway
  • neurotrophin TRK receptor signaling pathway
  • ephrin receptor signaling pathway
  • integrin-mediated signaling pathway
  • cytokine-mediated signaling pathway
  • regulation of cell adhesion mediated by integrin
  • interferon-gamma-mediated signaling pathway
  • regulation of multicellular organism growth
  • regulation of protein export from nucleus
  • regulation of interferon-gamma-mediated signaling pathway
  • brain development
  • glucose homeostasis
  • organ growth
  • inner ear development
  • abortive mitotic cell cycle
  • axon guidance
  • triglyceride metabolic process
  • phosphatidylinositol-mediated signaling
  • genitalia development
  • epidermal growth factor receptor signaling pathway
  • ERBB signaling pathway
  • positive regulation of ERK1 and ERK2 cascade
  • intestinal epithelial cell migration
  • innate immune response
  • homeostasis of number of cells within a tissue
Components
  • cytoplasm
  • mitochondrion
  • protein complex
  • nucleus
  • cytosol
General FunctionSh3/sh2 adaptor activity
Specific FunctionActs downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID4519425
UniProtKB IDQ06124
UniProtKB Entry NamePTN11_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019058|Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
ATGACATCGCGGAGATGGTTTCACCCAAATATCACTGGTGTGGAGGCAGAAAACCTACTG
TTGACAAGAGGAGTTGATGGCAGTTTTTTGGCAAGGCCTAGTAAAAGTAACCCTGGAGAC
TTCACACTTTCCGTTAGAAGAAATGGAGCTGTCACCCACATCAAGATTCAGAACACTGGT
GATTACTATGACCTGTATGGAGGGGAGAAATTTGCCACTTTGGCTGAGTTGGTCCAGTAT
TACATGGAACATCACGGGCAATTAAAAGAGAAGAATGGAGATGTCATTGAGCTTAAATAT
CCTCTGAACTGTGCAGATCCTACCTCTGAAAGGTGGTTTCATGGACATCTCTCTGGGAAA
GAAGCAGAGAAATTATTAACTGAAAAAGGAAAACATGGTAGTTTTCTTGTACGAGAGAGC
CAGAGCCACCCTGGAGATTTTGTTCTTTCTGTGCGCACTGGTGATGACAAAGGGGAGAGC
AATGACGGCAAGTCTAAAGTGACCCATGTTATGATTCGCTGTCAGGAACTGAAATACGAC
GTTGGTGGAGGAGAACGGTTTGATTCTTTGACAGATCTTGTGGAACATTATAAGAAGAAT
CCTATGGTGGAAACATTGGGTACAGTACTACAACTCAAGCAGCCCCTTAACACGACTCGT
ATAAATGCTGCTGAAATAGAAAGCAGAGTTCGAGAACTAAGCAAATTAGCTGAGACCACA
GATAAAGTCAAACAAGGCTTTTGGGAAGAATTTGAGACACTACAACAACAGGAGTGCAAA
CTTCTCTACAGCCGAAAAGAGGGTCAAAGGCAAGAAAACAAAAACAAAAATAGATATAAA
AACATCCTGCCCTTTGATCATACCAGGGTTGTCCTACACGATGGTGATCCCAATGAGCCT
GTTTCAGATTACATCAATGCAAATATCATCATGCCTGAATTTGAAACCAAGTGCAACAAT
TCAAAGCCCAAAAAGAGTTACATTGCCACACAAGGCTGCCTGCAAAACACGGTGAATGAC
TTTTGGCGGATGGTGTTCCAAGAAAACTCCCGAGTGATTGTCATGACAACGAAAGAAGTG
GAGAGAGGAAAGAGTAAATGTGTCAAATACTGGCCTGATGAGTATGCTCTAAAAGAATAT
GGCGTCATGCGTGTTAGGAACGTCAAAGAAAGCGCCGCTCATGACTATACGCTAAGAGAA
CTTAAACTTTCAAAGGTTGGACAAGGGAATACGGAGAGAACGGTCTGGCAATACCACTTT
CGGACCTGGCCGGACCACGGCGTGCCCAGCGACCCTGGGGGCGTGCTGGACTTCCTGGAG
GAGGTGCACCATAAGCAGGAGAGCATCATGGATGCAGGGCCGGTCGTGGTGCACTGCAGT
GCTGGAATTGGCCGGACAGGGACGTTCATTGTGATTGATATTCTTATTGACATCATCAGA
GAGAAAGGTGTTGACTGCGATATTGACGTTCCCAAAACCATCCAGATGGTGCGGTCTCAG
AGGTCAGGGATGGTCCAGACAGAAGCACAGTACCGATTTATCTATATGGCGGTCCAGCAT
TATATTGAAACACTACAGCGCAGGATTGAAGAAGAGCAGAAAAGCAAGAGGAAAGGGCAC
GAATATACAAATATTAAGTATTCTCTAGCGGACCAGACGAGTGGAGATCAGAGCCCTCTC
CCGCCTTGTACTCCAACGCCACCCTGTGCAGAAATGAGAGAAGACAGTGCTAGAGTCTAT
GAAAACGTGGGCCTGATGCAACAGCAGAAAAGTTTCAGATGA
GenBank Gene IDD13540
GeneCard IDNot Available
GenAtlas IDPTPN11
HGNC IDHGNC:9644
Chromosome Location12
Locus12q24
References
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