NameLymphotoxin-beta
Synonyms
  • LT-beta
  • TNF-C
  • TNFC
  • TNFSF3
  • Tumor necrosis factor C
  • Tumor necrosis factor ligand superfamily member 3
Gene NameLTB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002361|Lymphotoxin-beta
MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD
PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS
DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE
GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA
VMVG
Number of residues244
Molecular Weight25389.755
Theoretical pI5.02
GO Classification
Functions
  • receptor binding
Processes
  • positive regulation of interleukin-12 biosynthetic process
  • lymph node development
  • skin development
  • signal transduction
  • immune response
  • cell-cell signaling
  • gene expression
  • tumor necrosis factor-mediated signaling pathway
Components
  • plasma membrane
  • extracellular space
  • integral component of membrane
General FunctionReceptor binding
Specific FunctionCytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Pfam Domain Function
Transmembrane Regions19-48
GenBank Protein ID292279
UniProtKB IDQ06643
UniProtKB Entry NameTNFC_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0010827|Lymphotoxin-beta (LTB)
ATGGGGGCACTGGGGCTGGAGGGCAGGGGTGGGAGGCTCCAGGGGAGGGGTTCCCTCCTG
CTAGCTGTGGCAGGAGCCACTTCTCTGGTGACCTTGTTGCTGGCGGTGCCTATCACTGTC
CTGGCTGTGCTGGCCTTAGTGCCCCAGGATCAGGGAGGACTGGTAACGGAGACGGCCGAC
CCCGGGGCACAGGCCCAGCAAGGACTGGGGTTTCAGAAGCTGCCAGAGGAGGAGCCAGAA
ACAGATCTCAGCCCCGGGCTCCCAGCTGCCCACCTCATAGGCGCTCCGCTGAAGGGGCAG
GGGCTAGGCTGGGAGACGACGAAGGAACAGGCGTTTCTGACGAGCGGGACGCAGTTCTCG
GACGCCGAGGGGCTGGCGCTCCCGCAGGACGGCCTCTATTACCTCTACTGTCTCGTCGGC
TACCGGGGCCGGGCGCCCCCTGGCGGCGGGGACCCCCAGGGCCGCTCGGTCACGCTGCGC
AGCTCTCTGTACCGGGCGGGGGGCGCCTACGGGCCGGGCACTCCCGAGCTGCTGCTCGAG
GGCGCCGAGACGGTGACTCCAGTGCTGGACCCGGCCAGGAGACAAGGGTACGGGCCTCTC
TGGTACACGAGCGTGGGGTTCGGCGGCCTGGTGCAGCTCCGGAGGGGCGAGAGGGTGTAC
GTCAACATCAGTCACCCCGATATGGTGGACTTCGCGAGAGGGAAGACCTTCTTTGGGGCC
GTGATGGTGGGGTGA
GenBank Gene IDL11016
GeneCard IDNot Available
GenAtlas IDLTB
HGNC IDHGNC:6711
Chromosome Location6
Locus6p21.3
References
  1. Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF: Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell. 1993 Mar 26;72(6):847-56. 7916655
  2. Warzocha K, Renard N, Charlot C, Bienvenu J, Coiffier B, Salles G: Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas. Biochem Biophys Res Commun. 1997 Sep 18;238(2):273-6. 9299492
  3. Neville MJ, Campbell RD: A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. J Immunol. 1999 Apr 15;162(8):4745-54. 10202016
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