Bcl-2-like protein 1

NameBcl-2-like protein 1
Synonyms
  • Apoptosis regulator Bcl-X
  • Bcl2-L-1
  • BCL2L
  • BCLX
Gene NameBCL2L1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006782|Bcl-2-like protein 1
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Number of residues233
Molecular Weight26048.8
Theoretical pI4.58
GO Classification
Functions
  • protein homodimerization activity
  • identical protein binding
  • protein heterodimerization activity
  • BH3 domain binding
  • protein kinase binding
Processes
  • germ cell development
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
  • extrinsic apoptotic signaling pathway in absence of ligand
  • male gonad development
  • in utero embryonic development
  • negative regulation of release of cytochrome c from mitochondria
  • response to cytokine
  • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
  • negative regulation of neuron apoptotic process
  • cellular response to alkaloid
  • intrinsic apoptotic signaling pathway
  • negative regulation of anoikis
  • negative regulation of intrinsic apoptotic signaling pathway
  • innate immune response
  • hepatocyte apoptotic process
  • positive regulation of intrinsic apoptotic signaling pathway
  • spermatogenesis
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • negative regulation of execution phase of apoptosis
  • endocytosis
  • suppression by virus of host apoptotic process
  • response to cycloheximide
  • cellular response to amino acid stimulus
  • cellular response to gamma radiation
  • apoptotic mitochondrial changes
  • apoptotic process
  • negative regulation of apoptotic process
  • fertilization
  • programmed cell death
  • regulation of mitochondrial membrane permeability
  • positive regulation of cell proliferation
  • negative regulation of establishment of protein localization to plasma membrane
  • growth
  • ovarian follicle development
  • mitochondrion morphogenesis
  • cytokinesis
  • cell proliferation
  • apoptotic process in bone marrow
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  • neuron apoptotic process
  • cellular process regulating host cell cycle in response to virus
  • negative regulation of autophagy
  • regulation of mitochondrial membrane potential
  • mitotic cell cycle checkpoint
  • release of cytochrome c from mitochondria
Components
  • integral component of membrane
  • cytosol
  • nuclear membrane
  • cytoplasm
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial matrix
  • synaptic vesicle membrane
  • Bcl-2 family protein complex
  • centrosome
  • mitochondrial outer membrane
  • cell junction
General FunctionProtein kinase binding
Specific FunctionPotent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).Isoform Bcl-X(S) promotes apoptosis.
Pfam Domain Function
Transmembrane Regions210-226
GenBank Protein IDNot Available
UniProtKB IDQ07817
UniProtKB Entry NameB2CL1_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0017127|Bcl-2-like protein 1 (BCL2L1)
ATGTCTCAGAGCAACCGGGAGCTGGTGGTTGACTTTCTCTCCTACAAGCTTTCCCAGAAA
GGATACAGCTGGAGTCAGTTTAGTGATGTGGAAGAGAACAGGACTGAGGCCCCAGAAGGG
ACTGAATCGGAGATGGAGACCCCCAGTGCCATCAATGGCAACCCATCCTGGCACCTGGCA
GACAGCCCCGCGGTGAATGGAGCCACTGGCCACAGCAGCAGTTTGGATGCCCGGGAGGTG
ATCCCCATGGCAGCAGTAAAGCAAGCGCTGAGGGAGGCAGGCGACGAGTTTGAACTGCGG
TACCGGCGGGCATTCAGTGACCTGACATCCCAGCTCCACATCACCCCAGGGACAGCATAT
CAGAGCTTTGAACAGGATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGCCGAGAGC
CGAAAGGGCCAGGAACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTG
GTTCTGCTGGGCTCACTCTTCAGTCGGAAATGA
GenBank Gene IDBC019307
GeneCard IDNot Available
GenAtlas IDBCL2L1
HGNC IDHGNC:992
Chromosome Location20
LocusNot Available
References
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