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NameSerine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Synonyms
  • 3.1.3.16
  • Calmodulin-dependent calcineurin A subunit alpha isoform
  • CALNA
  • CAM-PRP catalytic subunit
  • CNA
Gene NamePPP3CA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008060|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
Number of residues521
Molecular Weight58687.27
Theoretical pI5.66
GO Classification
Functions
  • protein serine/threonine phosphatase activity
  • drug binding
  • calmodulin binding
  • calcium ion binding
  • protein dimerization activity
  • calmodulin-dependent protein phosphatase activity
  • enzyme binding
Processes
  • multicellular organismal response to stress
  • positive regulation of transcription from RNA polymerase II promoter
  • cellular response to glucose stimulus
  • stimulatory C-type lectin receptor signaling pathway
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • response to amphetamine
  • response to calcium ion
  • protein import into nucleus
  • positive regulation of cardiac muscle hypertrophy in response to stress
  • cellular response to drug
  • modulation of synaptic transmission
  • G1/S transition of mitotic cell cycle
  • skeletal muscle fiber development
  • T cell activation
  • calcium ion transport
  • transition between fast and slow fiber
  • protein dephosphorylation
  • cardiac muscle hypertrophy in response to stress
  • calcineurin-NFAT signaling cascade
  • negative regulation of chromatin binding
  • positive regulation of NFAT protein import into nucleus
  • negative regulation of dendrite morphogenesis
  • negative regulation of insulin secretion
  • excitatory postsynaptic potential
  • innate immune response
  • dephosphorylation
  • Fc-epsilon receptor signaling pathway
Components
  • sarcolemma
  • Z disc
  • cytoplasm
  • mitochondrion
  • calcineurin complex
  • cytosol
  • nucleoplasm
General FunctionProtein serine/threonine phosphatase activity
Specific FunctionCalcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID306477
UniProtKB IDQ08209
UniProtKB Entry NamePP2BA_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0019537|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PPP3CA)
ATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAGCT
GTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAA
CCTCGTGTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTT
GCATTGAGAATAATAACAGAGGGTGCATCAATTCTTCGACAGGAAAAAAATTTGCTGGAT
ATTGATGCGCCAGTCACTGTTTGTGGGGACATTCATGGACAATTCTTTGATTTGATGAAG
CTCTTTGAAGTCGGGGGATCTCCTGCCAACACTCGCTACCTCTTCTTAGGGGACTATGTT
GACAGAGGGTACTTCAGTATTGAATGTGTGCTGTATTTGTGGGCCTTGAAAATTCTCTAC
CCCAAAACACTGTTTTTACTTCGTGGAAATCATGAATGTAGACATCTAACAGAGTATTTC
ACATTTAAACAAGAATGTAAAATAAAGTATTCAGAACGCGTATATGATGCCTGTATGGAT
GCCTTTGACTGCCTTCCCCTGGCTGCCCTGATGAACCAACAGTTCCTGTGTGTGCATGGT
GGTTTGTCTCCAGAGATTAACACTTTAGATGATATCAGAAAATTAGACCGATTCAAAGAA
CCACCTGCATATGGACCTATGTGTGATATCCTGTGGTCAGACCCCCTGGAAGATTTTGGA
AATGAGAAGACTCAGGAACATTTCACTCACAACACAGTCAGGGGGTGTTCATACTTCTAC
AGTTACCCGGCTGTATGTGAATTCTTACAGCACAATAACTTGTTATCTATACTCCGAGCC
CACGAAGCCCAAGATGCAGGGTACCGCATGTACAGGAAAAGCCAAACAACAGGCTTCCCT
TCTCTAATTACAATTTTTTCAGCACCAAATTACTTAGATGTATACAATAACAAAGCTGCA
GTATTGAAGTATGAGAACAATGTTATGAATATCAGGCAATTCAACTGTTCTCCTCATCCA
TACTGGCTTCCAAATTTCATGGATGTTTTTACTTGGTCCCTTCCATTTGTTGGGGAAAAA
GTGACTGAGATGCTGGTAAATGTCCTCAACATCTGCTCAGATGATGAACTAGGGTCAGAA
GAAGATGGATTTGATGGTGCAACAGCTGCAGCCCGGAAAGAGGTGATAAGGAACAAGATC
CGAGCAATAGGCAAAATGGCCAGAGTGTTCTCAGTGCTCAGAGAAGAGAGTGAGAGTGTG
CTGACGCTGAAAGGCTTGACCCCAACTGGCATGCTCCCCAGCGGAGTACTTTCTGGAGGG
AAGCAAACCCTGCAAAGCGCTACTGTTGAGGCTATTGAGGCTGATGAAGCTATCAAAGGA
TTTTCACCACAACATAAGATCACTAGCTTCGAGGAAGCCAAGGGCTTAGACCGAATTAAT
GAGAGGATGCCGCCTCGCAGAGATGCCATGCCCTCTGACGCCAACCTTAACTCCATCAAC
AAGGCTCTCACCTCAGAGACTAACGGCACGGACAGCAATGGCAGTAATAGCAGCAATATT
CAGTGA
GenBank Gene IDL14778
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9314
Chromosome Location4
Locus4q21-q24
References
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