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C-Jun-amino-terminal kinase-interacting protein 2
Name | C-Jun-amino-terminal kinase-interacting protein 2 |
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Synonyms |
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Gene Name | MAPK8IP2 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0008804|C-Jun-amino-terminal kinase-interacting protein 2 MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSL SLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEEEGDGEGQEGGDPGSEAPA PGPLIPSPSVEEPHKHRPTTLRLTTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALR ELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPAPGGTSPSSDPGIEADLRSRSSGGR GGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSDGGSSSSGRSSHLTNSIEEA SSPASEPEPPREPPRRPAFLPVGPDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMIS EGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVELVDMETLCAPPPP APAAPRPGPAQPGPCLFLSNPTRDTITPLWAAPGRAARPGRACSAACSEEEDEEDDEEEE DAEDSAGSPGGRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDS GGEASEEEAGAALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLV NGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYA HAVPGPAKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLR PPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLS RFACHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE |
Number of residues | 824 |
Molecular Weight | 87973.915 |
Theoretical pI | Not Available |
GO Classification | Functions
Processes
Components
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General Function | Structural molecule activity |
Specific Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). |
Pfam Domain Function | |
Transmembrane Regions | Not Available |
GenBank Protein ID | Not Available |
UniProtKB ID | Q13387 |
UniProtKB Entry Name | JIP2_HUMAN |
Cellular Location | Cytoplasm |
Gene sequence | >lcl|BSEQ0013424|C-Jun-amino-terminal kinase-interacting protein 2 (MAPK8IP2) ATGGCGGATCGCGCGGAGATGTTTTCTCTCTCCACCTTCCACTCGCTGTCGCCGCCGGGC TGCAGGCCTCCCCAGGACATAAGCCTGGAAGAATTTGACGACGAAGATCTGTCTGAGATC ACTGATGACTGTGGCCTGGGCCTCAGCTACGACTCAGACCACTGTGAGAAGGACAGCCTC TCCCTGGGGCGCTCGGAGCAGCCGCACCCCATCTGCTCCTTCCAGGATGACTTCCAGGAG TTTGAGATGATCGATGACAATGAAGAGGAGGACGATGAGGACGAGGAAGAGGAGGAGGAG GAGGAGGAGGGAGATGGGGAAGGCCAGGAGGGAGGAGACCCTGGCTCAGAGGCACCTGCC CCCGGGCCCCTTATCCCCTCCCCTTCCGTGGAGGAGCCCCACAAGCACCGGCCCACCACC CTCCGTCTGACCACACTGGGGGCCCAGGACTCCCTAAACAACAACGGAGGCTTTGACCTG GTGCGTCCGGCCTCCTGGCAGGAGACAGCGCTATGCTCACCCGCCCCGGAGGCCCTCAGA GAGCTCCCGGGCCCCCTCCCTGCCACGGACACCGGGCCCGGCGGGGCGCAGTCGCCAGTG CGCCCGGGTTGCGACTGCGAAGGGAACCGGCCTGCGGAACCCCCTGCGCCAGGGGGGACT TCGCCCTCCTCAGATCCCGGCATCGAGGCTGACCTGAGAAGCCGCTCGAGCGGCGGCCGC GGGGGACGTCGCAGCAGCCAGGAGCTGTCCTCGCCCGGCTCCGACTCGGAGGACGCGGGC GGCGCGCGCCTGGGGCGCATGATCTCGTCCATCTCGGAGACGGAGCTGGAGCTGAGCAGC GATGGCGGAAGCAGCAGCAGCGGCCGCTCCTCGCACCTCACCAACTCCATCGAGGAGGCC TCGTCGCCCGCCTCGGAGCCGGAGCCCCCGCGCGAACCCCCGCGCCGCCCCGCCTTCCTG CCCGTGGGCCCCGACGACACCAACAGCGAGTACGAGTCGGGGTCGGAGTCGGAGCCGGAC CTCAGCGAGGACGCGGACTCGCCCTGGCTGCTCAGCAACCTGGTGAGCCGCATGATCTCC GAGGGCTCCTCGCCCATCCGCTGCCCCGGCCAGTGCCTGTCTCCTGCGCCGCGCCCGCCC GGGGAGCCCGTGTCGCCGGCCGGCGGGGCCGCCCAGGACTCCCAGGACCCCGAGGCGGCC GCGGGGCCCGGCGGCGTGGAGCTGGTGGACATGGAGACGCTGTGCGCGCCGCCGCCGCCC GCGCCCGCCGCGCCTCGACCCGGCCCCGCGCAGCCCGGGCCCTGCCTATTCCTCAGCAAC CCCACGCGTGACACCATCACGCCGCTGTGGGCCGCGCCCGGCCGCGCCGCCCGCCCGGGA CGAGCCTGCTCCGCCGCCTGCTCCGAGGAGGAGGACGAAGAGGACGACGAGGAAGAGGAG GATGCCGAGGACAGTGCGGGGTCCCCCGGGGGCAGGGGCACGGGCCCCTCGGCGCCGCGG GACGCGTCGCTGGTGTACGACGCGGTCAAGTACACGCTGGTGGTGGATGAGCACACGCAG CTGGAGCTGGTGAGCCTGCGGCGCTGTGCTGGGCTGGGCCACGACAGCGAAGAGGACAGC GGCGGGGAGGCCAGCGAGGAGGAGGCGGGCGCGGCGCTGCTAGGCGGCGGTCAGGTCTCG GGGGACACCTCGCCGGACAGCCCTGACCTCACTTTCTCCAAGAAGTTCCTCAATGTCTTC GTCAACAGCACATCTCGGTCCTCCAGCACCGAGTCCTTTGGCCTTTTCTCCTGTCTGGTC AACGGCGAGGAGCGAGAGCAGACTCACCGGGCTGTGTTCAGGTTCATCCCGCGGCATCCA GACGAGCTGGAGCTGGATGTGGATGACCCTGTGTTGGTGGAGGCCGAGGAGGACGACTTC TGGTTCCGTGGCTTCAACATGCGCACGGGGGAGCGCGGTGTGTTTCCTGCCTTCTACGCC CATGCGGTGCCCGGCCCTGCCAAGGACCTGCTGGGGAGTAAGCGGAGCCCCTGCTGGGTG GAGCGCTTTGACGTGCAGTTCCTGGGCTCCGTGGAGGTGCCCTGCCACCAGGGCAACGGC ATCCTGTGTGCAGCCATGCAGAAGATTGCCACTGCCCGGAAACTGACCGTCCACCTGCGC CCTCCTGCCTCCTGTGACCTCGAGATCTCTCTTCGGGGGGTCAAGCTGAGTCTGAGCGGA GGAGGGCCCGAGTTCCAGCGCTGCAGCCATTTCTTCCAGATGAAGAACATCTCCTTCTGC GGCTGCCATCCCCGCAACAGCTGCTATTTCGGCTTCATCACCAAACACCCCCTGCTGAGC CGCTTCGCCTGCCACGTCTTTGTCTCCCAGGAGTCCATGAGGCCGGTGGCGCAGAGTGTG GGCCGCGCCTTCCTGGAGTACTACCAAGAGCACCTGGCGTACGCCTGCCCCACGGAGGAC ATCTACCTGGAGTAG |
GenBank Gene ID | Not Available |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:6883 |
Chromosome Location | 22 |
Locus | Not Available |
References |
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