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Nucleolar and coiled-body phosphoprotein 1

NameNucleolar and coiled-body phosphoprotein 1
Synonyms
  • 140 kDa nucleolar phosphoprotein
  • HCV NS5A-transactivated protein 13
  • Hepatitis C virus NS5A-transactivated protein 13
  • KIAA0035
  • Nopp140
  • NS5ATP13
  • Nucleolar 130 kDa protein
  • Nucleolar phosphoprotein p130
Gene NameNOLC1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009848|Nucleolar and coiled-body phosphoprotein 1
MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS
AKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAA
AKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP
KNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPK
KTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPP
KKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE
SSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK
ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEE
EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR
PQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA
KKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQ
VLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKFDSE
Number of residues699
Molecular Weight73602.49
Theoretical pINot Available
GO Classification
Functions
  • poly(A) RNA binding
  • ATP binding
  • GTP binding
Processes
  • mitotic nuclear division
  • nucleolus organization
  • cell cycle
  • rRNA processing
Components
  • Cajal body
  • cytoplasm
  • nucleolus
  • nucleoplasm
General FunctionPoly(a) rna binding
Specific FunctionRelated to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ14978
UniProtKB Entry NameNOLC1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013947|Nucleolar and coiled-body phosphoprotein 1 (NOLC1)
ATGGCGGACGCCGGCATTCGCCGCGTGGTTCCCAGCGACCTGTATCCCCTCGTGCTCGGC
TTCCTGCGCGATAACCAACTCTCAGAGGTGGCCAATAAGTTCGCCAAAGCGACAGGAGCT
ACACAGCAGGATGCCAATGCCTCTTCCCTCTTAGACATCTATAGCTTCTGGCTCAAGTCT
GCCAAGGTCCCAGAGCGAAAGTTACAGGCAAATGGACCAGTGGCTAAGAAAGCTAAGAAG
AAGGCCTCATCCAGTGACAGTGAGGACAGCAGCGAGGAGGAGGAGGAAGTTCAAGGGCCT
CCAGCAAAGAAGGCTGCTGTACCTGCCAAGCGAGTCGGTCTGCCTCCTGGGAAGGCTGCA
GCCAAAGCATCAGAGAGTAGCAGCAGTGAAGAGTCCAGTGATGATGATGATGAGGAGGAC
CAAAAGAAACAGCCTGTCCAGAAGGGAGTTAAGCCCCAAGCCAAGGCAGCCAAAGCTCCT
CCTAAGAAGGCCAAGAGCTCTGATTCTGATTCTGACTCAAGCTCCGAGGATGAGCCACCA
AAGAACCAGAAGCCAAAGATAACACCTGTGACAGTTAAAGCTCAGACTAAAGCCCCTCCC
AAACCAGCTCGAGCAGCACCTAAAATAGCCAATGGTAAAGCAGCCAGTAGCAGCAGTAGC
AGCAGCAGCAGCAGTAGCAGTGATGACTCAGAGGAGGAGAAGGCAGCAGCCACCCCCAAG
AAGGTCTGGACCATAACTTCTGTCAGGGCAGAGACTGTACCTAAAAAGCAAGTTGTGGCC
AAGGCCCCAGTGAAAGCAGCTACCACCCCTACCCGGAAGAGTTCTAGCAGTGAGGATTCC
TCCAGTGACGAGGAAGAGGAGCAAAAAAAACCCATGAAAAATAAACCAGGTCCCTACAGT
TCAGTCCCCCCGCCTTCTGCTCCCCCACCAAAGAAGTCTCTGGGAACCCAGCCTCCCAAG
AAGGCTGTGGAGAAGCAGCAGCCTGTGGAAAGCAGTGAAGACAGCAGTGATGAGTCTGAT
TCAAGTTCTGAAGAAGAGAAGAAACCCCCAACTAAGGCAGTAGTCTCTAAAGCAACCACT
AAACCACCTCCAGCAAAGAAAGCAGCAGAGAGCTCTTCAGACAGCTCAGACTCTGACAGC
TCTGAGGATGATGAAGCTCCTTCTAAGCCAGCTGGTACCACCAAGAATTCTTCAAATAAG
CCAGCTGTCACCACCAAGTCACCTGCAGTGAAGCCAGCTGCAGCCCCCAAGCAACCTGTG
GGCGGTGGCCAGAAGCTTCTGACGAGAAAGGCTGACAGCAGCTCCAGTGAGGAAGAGAGC
AGCTCCAGTGAGGAGGAGAAGACAAAGAAGATGGTGGCCACCACTAAGCCCAAGGCGACT
GCCAAAGCAGCTCTATCTCTGCCTGCCAAGCAGGCTCCTCAGGGTAGTAGGGACAGCAGC
TCTGATTCAGACAGCTCCAGCAGTGAGGAGGAGGAAGAGAAGACATCTAAGTCTGCAGTT
AAGAAGAAGCCACAGAAGGTAGCAGGAGGTGCAGCCCCTTCCAAGCCAGCCTCTGCAAAG
AAAGGAAAGGCTGAGAGCAGCAACAGTTCTTCTTCTGATGACTCCAGTGAGGAAGAGGAA
GAGAAGCTCAAGGGCAAGGGCTCTCCAAGACCACAAGCCCCCAAGGCCAATGGCACCTCT
GCACTGACTGCCCAGAATGGAAAAGCAGCTAAGAACAGTGAGGAGGAGGAAGAAGAAAAG
AAAAAGGCGGCAGTGGTAGTTTCCAAATCAGGTTCATTAAAGAAGCGGAAGCAGAATGAG
GCTGCCAAGGAGGCAGAGACTCCTCAGGCCAAGAAGATAAAGCTTCAGACCCCTAACACA
TTTCCAAAAAGGAAGAAAGGAGAAAAAAGGGCATCATCCCCATTCCGAAGGGTCAGGGAG
GAGGAAATTGAGGTGGATTCACGAGTTGCGGACAACTCCTTTGATGCCAAGCGAGGTGCA
GCCGGAGACTGGGGAGAGCGAGCCAATCAGGTTTTGAAGTTCACCAAAGGCAAGTCCTTT
CGGCATGAGAAAACCAAGAAGAAGCGGGGCAGCTACCGGGGAGGCTCAATCTCTGTCCAG
GTCAATTCTATTAAGTTTGACAGCGAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:15608
Chromosome Location10
LocusNot Available
References
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  5. Pai CY, Yeh NH: Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130. Biochem Biophys Res Commun. 1996 Apr 25;221(3):581-7. 8630004
  6. Chen HK, Yeh NH: The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. Biochem Biophys Res Commun. 1997 Jan 13;230(2):370-5. 9016786
  7. Chen HK, Pai CY, Huang JY, Yeh NH: Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization. Mol Cell Biol. 1999 Dec;19(12):8536-46. 10567578
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