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Name3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Synonyms
  • 5.3.3.5
  • Cholestenol Delta-isomerase
  • D8-D7 sterol isomerase
  • Delta(8)-Delta(7) sterol isomerase
  • Emopamil-binding protein
Gene NameEBP
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017552|3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGT
WRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVC
METITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELG
HPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
Number of residues230
Molecular Weight26352.615
Theoretical pINot Available
GO Classification
Functions
  • steroid delta-isomerase activity
  • C-8 sterol isomerase activity
  • drug transmembrane transporter activity
  • transmembrane signaling receptor activity
  • cholestenol delta-isomerase activity
Processes
  • signal transduction
  • small molecule metabolic process
  • skeletal system development
  • cholesterol biosynthetic process
  • drug transmembrane transport
  • cholesterol metabolic process
  • hemopoiesis
Components
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
  • integral component of plasma membrane
General FunctionTransmembrane signaling receptor activity
Specific FunctionCatalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.
Pfam Domain Function
Transmembrane Regions29-49 66-86 121-141 185-205
GenBank Protein IDNot Available
UniProtKB IDQ15125
UniProtKB Entry NameEBP_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0017553|3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)
ATGACTACCAACGCGGGCCCCTTGCACCCATACTGGCCTCAGCACCTAAGACTGGACAAC
TTTGTACCTAATGACCGCCCCACCTGGCATATACTGGCTGGCCTCTTCTCTGTCACAGGG
GTCTTAGTCGTGACCACATGGCTGTTGTCAGGTCGTGCTGCGGTTGTCCCATTGGGGACT
TGGCGGCGACTGTCCCTGTGCTGGTTTGCAGTGTGTGGGTTCATTCACCTGGTGATCGAG
GGCTGGTTCGTTCTCTACTACGAAGACCTGCTTGGAGACCAAGCCTTCTTATCTCAACTC
TGGAAAGAGTATGCCAAGGGAGACAGCCGATACATCCTGGGTGACAACTTCACAGTGTGC
ATGGAAACCATCACAGCTTGCCTGTGGGGACCACTCAGCCTGTGGGTGGTGATCGCCTTT
CTCCGCCAGCATCCCCTCCGCTTCATTCTACAGCTTGTGGTCTCTGTGGGCCAGATCTAT
GGGGATGTGCTCTACTTCCTGACAGAGCACCGCGACGGATTCCAGCACGGAGAGCTGGGC
CACCCTCTCTACTTCTGGTTTTACTTTGTCTTCATGAATGCCCTGTGGCTGGTGCTGCCT
GGAGTCCTTGTGCTTGATGCTGTGAAGCACCTCACTCATGCCCAGAGCACGCTGGATGCC
AAGGCCACAAAAGCCAAGAGCAAGAAGAACTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:3133
Chromosome LocationX
LocusNot Available
References
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